Table 2.

Correlation between clinicopathologic findings and the prevalence of Tregs and CD8+ T cells infiltrating HCC

(A) Correlation between clinicopathologic findings and the prevalence of Tregs infiltrating HCC
VariablesPrevalence of Tregs among CD4+ T cells
High TregLow TregP
Age, y (mean ± SD)62.6 ± 8.9261.4 ± 10.40.444*
Gender (male/female)59/1454/200.259
Viral infection
    HBV and/or HCV/(−)66/769/50.531
    HBV(+)/(−)27/729/50.525
    HCV(+)/(−)45/743/50.640
Nontumor liver (NCH/CH/PC/LC)7/41/9/1610/30/14/200.289
Child-Pugh score (A/B/C)68/5/068/6/00.772
TNM stage (I/II/III/IV)28/22/23/029/31/14/00.155
Tumor size, mm (median, range)40, 9-18530, 6-1500.113
Histologic grade (early HCC/WD HCC/MD HCC/PD HCC)7/3/38/2510/12/39/130.021
AFP, ng/mL (median, range)24.1 (1.8-27,170)28.3 (1.0-25,000)0.681
VP (presence/absence)33/4024/500.112
IM (presence/absence)20/5313/610.152
Number of CD8+ T cells infiltrating tumor (median, range)75 (12-405)91 (9-435)0.064
(B) Correlation between clinicopathologic findings and the prevalence of CD8+ T cells infiltrating HCC
Variables
Prevalence of CD8+ T cells in total T cells
High CD8+ T cellsLow CD8+ T cellsP
Age, y (mean ± SD)63.6 ± 9.0860.5 ± 10.00.051*
Gender (male/female)51/2362/120.045
Viral infection
    HBV and/or HCV/(−)69/466/80.238
    HBV(+)/(−)30/426/80.203
    HCV(+)/(−)42/446/80.348
Nontumor liver (NCH/CH/PC/LC)11/35/12/156/36/11/210.471
Child-Pugh score (A/B/C)67/6/069/5/00.736
TNM stage (I/II/III/IV)28/29/16/029/24/21/00.560
Tumor size, mm (median, range)40, 6-18531, 10-1500.075
Histologic grade (early HCC/WD HCC/MD HCC/PD HCC)9/8/39/178/7/38/210.907
AFP, ng/mL (median, range)21.5 (1.0-27,170)36.3 (1.8-17,430)0.105
VP (presence/absence)31/4226/480.362
IM (presence/absence)18/5515/590.524
  • Abbreviations: MD, moderately differentiated; PD, poorly differentiated; WD, well differentiated.

  • * Student's t test.

  • χ2 test or Fisher exact test.

  • Mann-Whitney U test.