Table 2.

Expression of GPC3, PEG10, MDK, SERPINI1, and QP-C in HCC determined by qRT-PCR

RangeTotal (N)HCC cases that are positive for the expression*
GPC3, n (%)PEG10, n (%)MDK, n (%)SERPINI1, n (%)QP-C, n (%)
AFP status (ng/mL)
    AFP high329-4,62033 (100)2 (67)3 (100)3 (100)0 (0)
    AFP normal1-181815 (83)12 (67)12 (67)16 (89)12 (67)
Tumor size (cm in diameter)
    <31.1-2.977 (100)4 (57)5 (71)7 (100)7 (100)
    3-53-4.788 (100)6 (75)7 (100)7 (88)3 (38)
    ≥55.2-1563 (50)4 (67)4 (67)5 (83)4 (67)
Tumor-node-metastasis staging
    EarlyI98 (89)5 (56)7 (78)7 (78)8 (89)
    IntermediateII97 (78)7 (78)7 (78)7 (100)6 (67)
    AdvancedIII-IV33 (100)2 (67)3 (100)3 (100)0 (0)
  • * A HCC case is considered positive when the lowest value of triplicate readings of a given gene is above the defined threshold. The normal threshold is defined as the mean expression level of a given gene in 31 independent noncancerous liver tissues plus two SDs. Only independent 21 HCC samples and 31 noncancerous liver specimens that were not used in microarray analysis were included in this table.