Table 4.

HR estimates for treatment modality (CRT-S versus S) by ERCC1 expression adjusting for age, clinical stage, and ECOG performance status

Clinical outcomeERCC1 negative
ERCC1 positive
HR (95% CI)PHR (95% CI)P
EFS
    Age <63 y0.90 (0.47-1.74)0.7591.57 (0.83-2.97)0.163
    ECOG <10.41 (0.15-1.17)0.0950.31 (0.11-0.89)0.030
    Stage II0.35 (0.17-0.74)0.0050.65 (0.34-1.24)0.193
    R0 resection0.15 (0.31-0.70)0.0161.47 (0.20-10.89)0.707
    CRT-S arm0.30 (0.12-0.70)0.0061.01 (0.52-1.94)0.988
OS
    Age <63 y0.98 (0.49-1.95)0.9551.41 (0.71-2.80)0.321
    ECOG <10.53 (0.18-1.52)0.2390.41 (0.15-1.11)0.080
    Stage II0.30 (0.14-0.62)0.0010.80 (0.40-1.63)0.544
    R0 resection0.09 (0.02-0.42)0.0021.16 (0.15-8.68)0.887
    CRT-S arm0.33 (0.14-0.75)0.0081.17 (0.57-2.43)0.669