Baseline cytokine levels and responses
| Participant group | Baseline IL-6 level (pg/mL) | Baseline IL-8 level (pg/mL) | Baseline IL-10 level (pg/mL) | Baseline IL-1RA level (pg/mL) | ||||
|---|---|---|---|---|---|---|---|---|
| Normal volunteers, median (range) | Undetectable (undetectable to 4.3) | Undetectable (undetectable to 33.0) | Undetectable (undetectable to 18.0) | 275.0 (65.0-1,484.0) | ||||
| Patients with pancreatic cancer, median (range) | 5.9 (2.9-36.0) | 30.6 (12.0-235.0) | 13.4 (<3.9-25.0) | 507.0 (275.0-1,757.0) | ||||
| Responders | ||||||||
| Patient 8 (73% decrease according to Response Evaluation Criteria in Solid Tumors) | 2.7 | 25.0 | 7.6 | 1,071.7 | ||||
| Patient 14 (stable for ≥12 months) | 5.52 | 55.2 | 19.47 | 1,757.2 | ||||
NOTE: The lower limits of the assay sensitivity were as follows: IL-6, 0.7 pg/mL; IL-8, 3.5 pg/mL; IL-10, 3.9 pg/mL; and IL-1RA, 22.0 pg/mL.