Table 1.

Summary of targeting strategies to inhibit IKK activity

StrategiesPotential targetsTherapeutic agentsReferences
Small molecule inhibitorsIKKα/βPS-1145Castro et al. (44), Hideshima et al. (45)
BMS-345541Burke et al. (46), Mclntyre et al. (47)
SPC-839Palanki et al. (48)
CHS828Hiarnaa et al. (51), Olsen et al. (52)
IKKβML120BWen et al. (49)
SC-514Kishore et al. (50)
TBK1SU6668Godl et al. (39)
RNA interference and small interfering RNAsIKKα/β/ε and TBK1Takaesu et al. (54)
Gene therapyIKKβE1AShao et al. (55, 56)
Cell-permeable peptidesIKKα/β/γ complexIKKβ[644-756] peptideMay et al. (61)