Table 3.

Univariate analyses of PFS and OS of stage 4 patients with MRD in the bone marrows after 2 cycles of immunotherapy

MarkerLevel 1: histology-negative (n = 90)
Level 2: aspirate-negative (n = 94)
Level 3: isolated infiltration (n = 105)
PFS POS PPFS POS PPFS POS P
CCND10.0330.0150.0270.0130.0020.001
DDCNSNSNSNS0.0140.022
GABRB3NSNSNSNS0.0090.067
ISL10.08NS0.060.08<0.001<0.001
KIF1ANSNS0.080.080.0010.002
PHOX2B0.07NS0.0090.032<0.001<0.001
  • NOTE: Histology-negative: negative in 2 of 2 biopsy and 4 of 4 aspirate sites. Aspirate-negative: only aspirates were considered, negative in 4 of 4 sites. Isolated infiltration: negative in ≥4 of 6 sampling sites. NS, P > 0.1.