Table 3.

Multivariate Cox regression analyses of histopathologic variables, risk factors, and gene expressions on disease-specific, metastasis-free, and recurrence-free survival in bladder cancer patients

VariablesDisease-specific survivalMetastasis-free survivalRecurrence-free survival
HR (95% CI)PHR (95% CI)PHR (95% CI)P
Stage9.655 (2.666-34.960)0.00122.211 (3.357-146.945)0.0018.853 (2.220-35.299)0.002
    Noninvasive (n = 48)
    Invasive (n = 65)
Grade0.97 (0.397-2.365)0.9460.653 (0.196-2.176)0.4870.347 (0.097-1.246)0.105
    Low grade (n = 57)
    High grade (n = 56)
Smoking0.650 (0.324-1.305)0.2261.115 (0.397-3.131)0.8370.632 (0.227-1.755)0.378
    Yes (n = 49)
    No (n = 54)
    Unknown (n = 10)
Age0.993 (0.488-2.019)0.9850.685 (0.234-2.009)0.4911.011 (0.340-3.007)0.984
    ≤65 (n = 51)
    >65 (n = 62)
Recurrent1.341 (0.672-2.676)0.4060.942 (0.342-2.593)0.9070.209 (0.072-0.605)0.004
    Yes (n = 63)
    No (n = 50)
VEGF expression1.499 (0.735-3.059)0.2662.55 (0.928-7.011)0.0700.549 (0.190-1.583)0.267
    Low (n = 53)
    High (n = 54)
Ang-1 expression1.655 (0.668-4.100)0.277— (—)1.072 (0.331-3.472)0.908
    Low (n = 50)
    High (n = 50)
Ang-2 expression1.040 (0.430-2.516)0.9310.711 (0.216-2.342)0.57510.179 (2.691-38.498)0.001
    Low (n = 53)
    High (n = 55)
Tie2 expression0.249 (0.100-0.619)0.0030.311 (0.109-0.889)0.0290.727 (0.241-2.204)0.573
    Low (n = 52)
    High (n = 51)