Table 3.

Multivariate analysis (Cox model) of evolution to MM in IgG training sample and IgA MGUS patients

IgG training sample
FactorCoefficientSEHRPBoot-SE*Boot-P*
MC >1.5 g/dL1.190.3293.29<0.0010.3590.001
Light-chain proteinuria0.920.3582.500.0100.4210.029
Serum pIg reduction0.820.3182.270.0100.3600.023
Shrinkage factor, 0.942; C-Harrell, 0.760 (95% CI, 0.693-0.826)
ScoreN%HRP
Low (0)341621.00
Intermediate (1)167305.04<0.001
High (2-3)45811.2<0.001
IgA patients
Factor
Coefficient
SE
HR
P
Boot-SE*
Boot-P*
Hb <12.5 g/dL0.940.4032.570.0190.4450.037
Serum pIg reduction1.010.4022.760.0110.4440.020
Shrinkage factor, 0.919; C-Harrell, 0.723 (95% CI, 0.626-0.820)
ScoreN%HRP
Low (0)160561.00
High (1-2)125444.130.001
  • Abbreviation: pIg, polyclonal immunoglobulin.

  • * More than 1,000 bootstrap replications.

  • More than 250 bootstrap replications.