Table 4.

Validation of risk stratification model proposed by Rajkumar et al. (10) for evolution to MM in pooled MGUS patients

FactorUnivariate Cox proportional hazard
Multivariate Cox proportional hazard
HRPHRP
MC >1.5 g/dL2.97<0.0012.98<0.001
Light-chain proteinuria3.34<0.0013.10<0.001
IgA vs IgG MGUS1.290.2411.690.020
Risk levels
No. of patients (%)
HR
P
10-y PFS (%)
Low (0)590 (48)1.0094
Low-intermediate (1)511 (41)3.79<0.00183
Intermediate-high (2)129 (10)6.23<0.00174
High (3)5 (<1)26.30<0.00140
Total1,235
C-Harrell, 0.64 (95% CI, 0.60-0.71)