Table 3.

OS and BCSS by PIK3CA mutation type

Mutation typeOS (95% CI)BCSS (95% CI)
Survival ratesProbabilities of death
5 y10 yP5 y10 yP
Wild-type77% (73-81)62% (57-67)14% (11-18)23% (18-27)
vs
Any PIK3CA mutation85% (78-89)71% (63-77)0.037% (4-11)12% (7-17)0.004
    HS mutation86% (79-91)70% (61-78)0.065% (1-9)11% (6-17)0.01
        HS kinase89% (80-94)76% (65-84)0.0055% (0-10)11% (4-19)0.03
        HS helical82% (68-90)59% (43-72)0.546% (0-13)11% (2-20)0.13
    Rare PIK3CA mutation80% (64-89)72% (56-83)0.1914% (3-24)0.10