Table 5.

Pharmacokinetic parameters for carfilzomib (11, 15, and 20 mg/m2 dose levels)

11 mg/m2n = 215 mg/m2n = 520 mg/m2n = 4
Cmax, ng/mL
    Mean90.2325.9683.0
    SD84.9217.8598.5
    Min, max28.0, 187.083.7, 620.0151.0, 1,450.0
Tmax, minutes
    Mean9.05.86.0
    SD3.41.11.1
    Min, max7.0, 13.05.0, 7.05.0, 7.0
C0, ng/mL
    Mean7622,1235,454
    SD6232,6024,432
    Min, max182, 1,4220.39, 6,521594, 10,606
AUClast, ng·mL/h
    Mean4,4579,72823,123
    SD2,52010,89717,323
    Min, Max1,757, 6,7501,616, 28,4263,659, 40,264
AUCinf, g·mL/h
    Mean4,4639,76023,660
    SD2,51910,89318,011
    Min, max1,767, 6,7561,621, 28,4333,663, 42,164
t1/2 minutes
    Mean25.328.917.1
    SD14.137.47.7
    Min, Max11.4, 39.66.8, 95.511.2, 28.3
CL, mL/min
    Mean5,0627,0544,127
    SD3,9587,1774,981
    Min, max2,486, 9,620950, 18,511854, 11,465
Vz, L
    Mean23419284.7
    SD27617890.0
    Min, max41.1, 55016.0, 39219.3, 216
Vss, L
    Mean42.5942140
    SD65.22046231
    Min, max4.02, 1171.47, 46034.25, 485

Abbreviations: Cmax, maximum concentration; Tmax, time of maximum concentration; C0, concentration at t = 0 (extrapolated); AUClast, area under the curve to last measurable time point (includes C0); AUCinf, area under the curve to infinity (included C0); Lambda z, elimination rate constant; t1/2, elimination half-life; CL, systemic clearance; MRTlast, mean residence time to last measurable concentrations; Vz, initial volume of distribution; Vss, volume of distribution to steady state.