Table 4.

Pharmacokinetic parameters of romidepsin estimated from the final model

ParameterNONMEM estimateBootstrap analysis
Median (%RSE)95% CI
CL (L/h)15.9*15.9 (6.2)14.0 - 17.7
V1 (L)109.71 (8.9)7.8 - 11.2
Q (L/h)0.9961.01 (14.7)0.80 - 1.40
V2 (L)4.724.73 (11.1)3.92 - 5.93
BSVCL (%CV)37.136.6 (11.8)28.5 - 45.1
BSVV1 (%CV)39.038.9 (25.9)23.2 - 63.1
BSVQ (%CV)39.639.5 (22.8)24.9 - 60.1
BSVV2 (%CV)28.928.2 (22.6)16.3 - 40.8
CorrCL-Q0.7810.781 (18.6)0.394 - 0.928
CorrQ-V1−0.588−0.541 (28.7)−0.748 - -0.203
Residual error (%CV)28.629.3 (10.5)24.4 - 36.3
  • Abbreviations: %RSE, relative standard error of parameter estimate; CI, confidence intervals; BSV, between subject variability in parameters; %CV, percent of coefficient of variation; Corr, correlation between individual parameters.

  • * CL = 15.9 × (BSA/1.935). Typical value of CL for a patient with BSA = 1.935 m2.