Table 1.

Clinical characteristics of B-CLL patients

PatientsSex/AgeStage*ZAP70/CD38Ig statusGenetic alterations
P1M/76B/IIND/+Mutateddel13q14
P2F/35B/IIND/−Mutateddel13q14
P3M/62B/II+/−Unmutateddel13q14
P4F/73A/0+/−Mutateddel13q14, Trisomy 12
P5M/56A/I+/+NDdel13q14
P6F/73A/0+/+MutatedTrisomy 12
P7M/64A/0ND/−NDNo
P8M/42C/IV+/−NDNo
P9F/80B/II−/−MutatedT 14;19
P10M/65B/II+/−Mutateddel13q14
P11F/63A/0−/−NDdel13q14, del17p13
P12F/72B/IIND/+UnmutatedTrisomy 12
P13M/47A/0−/−MutatedNo
P14M/53C/IIIND/−NDdel13q14
P15F/78A/0−/−UnmutatedNo
P16M/63B/II+/+MutatedNo
P17F/59A/0+/−UnmutatedNo
P18M/74A/0−/−NDdel13q14
P19F/81A/0−/−MutatedNo
P20M/54A/0ND/NDUnmutatedND
P21M/82A/0−/−Unmutateddel17p13
P22F/75A/0ND/+Mutateddel13q14
P23M/54B/II+/+UnmutatedNo
P24F/71A/0−/−Unmutateddel13q14
P25M/78B/IIND/−UnmutatedTrisomy 12
P26M/60A/0−/−Mutateddel13q14
P27M/55A/II+/+Unmutateddel13q14
P28F/71B/II+/+Mutateddel17p13

Abbreviation: ND, not determined.

  • *According to Rai et al. (40) and Binet et al. (41).

  • The CD38 and ZAP70 expression in B-CLL cells has prognostic value (1, 2). None of the patients had received previous treatment at the time of this study.