Table 1.

Summary of known hypoxia-induced DNA repair defects and anticancer agents with potential for increased efficacy

Hypoxia-mediated defect in DNA repairChemotherapeutic agents with potential for increased efficacyClass of agent showing synthetic lethality
HR (e.g., RAD51, RAD54, BRCA1, BRCA2, XRCC3)Alkylators, topisomerase inhibitors, ionizing radiationPARP inhibitors
MMR (e.g., MLH1, MSH2, MSH6)Alkylators, topisomerase inhibitorsDNA polymerase inhibitors