Table 1.

Drug interactions between olaparib and alkylators

KP-3.33KP-6.3KB2P-3.4KB2P-3.4R3KB2P1.21KB2P-1.21R2
Olaparib+
    Chlorambucil−0.06−0.05−0.21−0.04−0.170.02
    Melphalan−0.05−0.07−0.14−0.08−0.16−0.06
    Nimustine−0.05−0.02−0.22−0.07−0.17−0.06

NOTE: Averaged combination index values of olaparib and alkylators, tested on the complete cell-line panel. Synergistic interactions, with an average combination index of <−0.15, are highlighted.