Table 1.

Relationships of HPV16/18 E6 with EGFR, p-AKT, and cIAP2, correlation of EGFR with p-AKT and cIAP2, and correlation between p-AKT and cIAP2 in lung tumors

TotalEGFRp-AKTcIAP2
NNegativePositiveNegativePositiveNegativePositive
n (%)n (%)n (%)n (%)n (%)n (%)
13661 (45)75 (55)51 (38)85 (62)59 (43)77 (57)
HPV16 or HPV18 E6
    Negative7941 (52)38 (48)37 (47)42 (53)41 (52)38 (48)
    Positive5720 (35)37 (65)14 (25)43 (75)18 (32)39 (68)
    P0.0520.0080.018
EGFR
    Negative6133 (54)28 (46)37 (61)24 (39)
    Positive7518 (24)57 (76)22 (29)53 (71)
    P<0.001<0.001
p-AKT
    Negative5133 (65)18 (35)
    Positive8526 (31)59 (69)
    P<0.001
EGFR gene
    Wild-type9347 (51)46 (49)
    Mutant4312 (28)31 (72)
    P0.013

NOTE: P value was calculated by χ2 test. EGFR gene mutation in exons 18 to 21 was determined by direct autosequencing.