Table 1.

Percutaneous absorption of CUR61414 (% of applied dosea)

CUR61414, %Benzyl alcohol, %Single tapestripEpidermisDermisReceptorDose recovered
106.66 ± 2.9511.35 ± 1.834.73 ± 2.652.89 ± 0.63102.84 ± 9.17
114.39 ± 1.958.38 ± 1.887.85 ± 6.272.83 ± 0.5491.26 ± 4.01
124.94 ± 2.226.79 ± 1.272.50 ± 1.432.05 ± 0.04101.55 ± 18.99
133.60 ± 0.526.62 ± 1.261.69 ± 0.882.97 ± 1.1698.98 ± 12.78
205.10 ± 0.505.57 ± 1.612.55 ± 1.331.99 ± 0.4190.05 ± 13.08
215.94 ± 1.536.28 ± 3.182.72 ± 1.372.28 ± 0.4191.86 ± 7.38
226.55 ± 2.367.11 ± 1.962.03 ± 1.461.89 ± 0.1982.86 ± 5.18
405.35 ± 1.074.25 ± 0.651.96 ± 2.661.79 ± 0.2091.44 ± 7.68
415.00 ± 0.734.91 ± 1.541.80 ± 0.902.09 ± 0.3094.58 ± 10.02
425.21 ± 2.245.64 ± 2.571.72 ± 1.351.90 ±0.2087.87 ± 5.58
  • aMean ± SD.