Table 4.

Logistic regression analysis for the relation between clinicopathological characteristics and stainings

Smad4 (n = 255)Smad4–Smad4+Smad4 positive OR (95% CI)
n/total%n/total%
Age (continuous)
Age ≥43111/22050%21/3560%1.00 (0.98–1.03)
Stage ≥Ib283/22038%11/3531%0.76 (0.35–1.62)
SCC150/20673%20/3165%0.68 (0.31–1.51)
Poor differentiation87/21640%17/3450%1.48 (0.72–3.06)
Lymphangioinvasion119/22054%15/3543%0.64 (0.31–1.31)
Infiltration depth ≥10 mm111/20754%10/3529%0.35 (0.16–0.76)
Tumor diameter ≥4 cm65/22030%6/3517%0.49 (0.20–1.24)
Positive lymph nodes71/22032%3/359%0.20 (0.06–0.66)
p120 (n = 268)p120–p120+p120 positive
n/total%n/total%OR (95% CI)
Age (continuous)
Age ≥4378/15650%60/11254%1.00 (0.98–1.02)
Stage ≥Ib258/15637%40/11236%0.94 (0.57–1.56)
SCC88/14262%90/10883%3.07 (1.67–5.64)
Poor differentiation64/15342%41/11037%0.83 (0.50–1.37)
Lymphangioinvasion70/15645%68/11261%1.90 (1.16–3.11)
Infiltration depth ≥10 mm70/14748%54/10850%1.10 (0.67–1.81)
Tumor diameter ≥4 cm44/15628%31/11228%0.97 (0.57–1.67)
Positive lymph nodes37/15624%40/11236%1.79 (1.05–3.05)
β-catenin (n = 272)β-catenin−β-catenin+β-catenin positive
n/total%n/total%OR (95% CI)
Age (continuous)
Age ≥4363/13248%76/14054%1.01 (0.99–1.03)
Stage ≥Ib248/13236%52/14037%1.03 (0.63–1.69)
SCC81/12664%101/12978%2.00 (1.15–3.49)
Poor differentiation52/13239%53/13539%0.99 (0.61–1.62)
Lymphangioinvasion63/13248%77/14055%1.34 (0.83–2.16)
Infiltration depth ≥10 mm64/12551%61/13446%0.80 (0.49–1.30)
Tumor diameter ≥4 cm38/13229%38/14027%0.92 (0.54–1.57)
Positive lymph nodes37/13228%43/14031%1.14 (0.67–1.92)

NOTE: Bold signifies P < 0.05

SCC = squamous cell carcinoma

The proportion of patients with less than 2 representative tissue cores varied from 1%–7%