Table 1

Frequency of statistically significant inhibition as determined by Student’s t test of colony formation by rhMIS

Greater than 50% inhibition was achieved in >81% of colony inhibition experiments on ovarian cancer cell lines (n = 33). No inhibition was seen with COS cells or SKOV3 cells, as observed previously. Biologically inactive L9 caused no inhibition of colony growth when tested on OVCAR5 at 71 nm (n = 2).
Concentration of added MIS
Cell line107 nm71 nm35.5 nm
OVCAR34/61/10/1
OVCAR53/33/32/3
OV10634/51/10/1
OVCAR84/41/11/1
IGROV-13/3
SKOV-30/2
COS0/3