Table 3

Mcm labeling indices for stratified squamous epitheliaa

TissueConditionnMcm 5 (%)Mcm 2 (%)
CervixNormal314 (12–17)b17 (15–19)b
CIN I252 (48–57)44 (37–52)
CIN III798 (95–100)97 (90–100)
SCC695 (90–98)94 (93–97)
SkinNormal317 (14–22)c19 (12–28)c
Psoriasis321 (15–25)30 (22–37)
Bowen’s disease590 (78–98)89 (86–96)
SCC785 (73–95)79 (70–95)
LarynxNormal419 (7–22)d16 (15–20)d
SCC890 (57–95)70 (59–100)
EsophagusNormal317 (10–20)e14 (7–31)e
SCC397 (90–98)90 (88–95)
LungNormal415 (4–17)10 (8–12)
SCC394 (78–96)f90 (89–95)
  • a This table shows the median labeling indices (percentage of stained cells) for stratified squamous epithelia, when stained for Mcm 2 and Mcm 5. Ranges are given in parentheses. There was striking similarity among labeling indices in normal tissues, with significantly higher labeling indices in dysplastic/neoplastic tissues.

  • b Normal cervix vs. CIN III, P < 0.05 for Mcm 2 and Mcm 5; normal cervix vs. SCC, P < 0.05 for Mcm 2 and Mcm 5.

  • c Normal skin vs. psoriasis, P not significant; normal skin vs. Bowen’s disease, P < 0.05 for Mcm 2 and Mcm 5; normal skin vs. SCC, P < 0.05 for Mcm 2 and Mcm 5.

  • d Normal larynx vs. SCC, P < 0.01 for Mcm 5, P < 0.05 for Mcm 2.

  • e Normal esophagus vs. SCC: P not significant.

  • f One additional case of small cell carcinoma of the lung was found to have >90% positive immunostaining with Mcm 2 and Mcm 5 antibodies (Fig. 3C).