Table 1

%Effect of AAAD inhibitors on intact NCI-H727 carcinoid cellsa

InhibitorCytotoxicity (IC50, μm)AAAD inhibition (IC50, μm)
Carbidopa29 ± 216 ± 5
MFMD56 ± 62 ± 0.3
NSD-1015None detectedIncomplete
  • a Cells (50,000/plate) were incubated continuously at 37°C with increasing concentrations of inhibitor (≤100 μm) for 72 h prior to cytotoxicity measurement by trypan blue exclusion or for 10 min before determination of AAAD activity in broken-cell preparations (average ± SE; n = 3).