Table 2

Antitumoral effects of cisplatin, Met-free diet, and ethionine on the growth of TC71-MA, a human colon cancer grafted into nude mice

DietTreatmentRTV at day 33 Mean ± SDTumor growth inhibition (%) Mean ± SDTumor doubling time (days) Mean ± SDSurvival prolongation (days) Mean ± SD (ratio)a
Regular dietNone21 ± 411 ± 1
Regular dietEthionineb23 ± 26 ± 712 ± 11
MetHcy+1cNone11 ± 1d46 ± 13d13 ± 112d (2.1)
MetHcy+Ethionine9 ± 1e56 ± 10e26 ± 2e27e (2.8)
Regular dietCisplatinf18 ± 317 ± 814 ± 26
Regular dietCisplatin+ ethionine19 ± 311 ± 89 ± 13
MetHcy+Cisplatin9 ± 2e56 ± 16e23 ± 1e27e (2.8)
MetHcy+Cisplatin+ ethionine8 ± 1e61 ± 15e28 ± 1e33e (3.3)
  • a Ratio to the survival time of untreated mice.

  • b Ethionine was injected i.p. daily, at a dose of 200 mg/kg.

  • c Mice were fed a MetHcy+ diet as soon as the tumors reached 60–100 mm3.

  • d 0.05 < P < 0.01.

  • e P < 0.01.

  • f Cisplatin was injected i.p., 1 mg/kg, for 5 consecutive days, every 2 weeks.