Table 4

Antitumoral effects of carmustine, Met-free diet, and ethionine on the growth of SNB19, a human glioma established in nude mice

DietTreatmentRTV at day 24 Mean ± SDTumor growth inhibition (%) Mean ± SDTumor doubling time (days) Mean ± SDSurvival prolongation (days) Mean ± SD (ratio)a
Regular dietNone24 ± 411 ± 1
Regular dietCarmustineb17 ± 230 ± 712 ± 12
MetHcy+cEthionined13 ± 1e46 ± 13e13 ± 14
MetHcy+Carmustine+ ethionine5 ± 1f80 ± 10f26 ± 2f27f (2)
  • a Ratio to the survival time of untreated mice.

  • b Carmustine was injected i.p. 6 mg/kg, for 3 consecutive days, for 3 weeks.

  • c Mice were fed a MetHcy+ diet as soon as the tumors reached 60–100 mm3.

  • d Ethionine was injected i.p. daily, at a dose of 200 mg/kg.

  • e 0.05 < P < 0.01.

  • f P < 0.01.