Table 4

Maximum grade of hepatotoxicity observed with 9cRAa

Dose level (mg/m2/day)No. evaluable patientsGrade of hepatotoxicity
1234
35612
50101b
6533
85851
1102
  • a Number of patients are shown for each grade.

  • b Patient treated at 50 mg/m2/day who developed grade 2 hepatotoxicity was >12 years of age.