Table 2

Cross-resistance profile of the MCF-7 FLV1000 cell line

DrugMCF-7 IC50am)MCF-7 FLV1000 IC50am)RRb
Flavopiridol0.18 ± 0.044.3 ± 2.424
Topotecan0.03 ± 0.00512.7 ± 3.8423
Mitoxantrone0.004 ± 0.0022.7 ± 0.04675
SN-380.002 ± 0.0011.9 ± 0.3950
Taxol0.005 ± 0.00070.018 ± 0.0094
5-FU0.83 ± .0218.3 ± 1.510
  • a IC50 values were determined by the sulforhodamine B assay.

  • b Relative resistance values were determined by dividing the IC50 for the resistant cell line by the IC50 for the parental cell line. Experiments were performed at least three times.