Table 2

Mutations of the p53 gene in patients with field cancerization

TumorField
PatientMutationExonChangeCodonAmino acid changeMutationa
1+61-bp ins220–221FrameshiftId. (F2)
2+7G→A238Cys→TyrId. (F1, F2, F4, A, B)
7
10+8G→T298Glu→StopNeg. (F4, B)
11+5G→A175Arg→HisNeg. (F5, D, E)
16+8C→G283Arg→GlyId. (F3, C); Neg. (F2, F5)
17+5G→A141Cys→TyrId. (F1)
25+81-bp del280FrameshiftId. (F4)
26+7C→T248Arg→TrpId. (F4, F5, C)
28
  • a Id. means that the p53 mutation of the tumor was identical to the mutation of the field samples listed in parentheses. Neg. means that the mutation of the tumor was not confirmed in the field samples listed in parentheses. Confirmation was established by sequencing. ins, insertion; del, deletion.