Table 6

Noncardiac toxicities of combined doxorubicin and paclitaxel: Number of patients (%) with worst grade toxicity for each category

ToxicityaGrade
1-h Paclitaxel3-h Paclitaxel
1–23451–2345
Hematological
 Granulocytopenia2 (5)26 (63)3 (7)32 (78)
 Thrombocytopenia21 (51)11 (27)1 (2)4 (10)5 (12)1 (2)
 Anemia5 (12)4 (10)1 (2)3 (7)8 (20)2 (5)
Infectious
 Infection12 (29)9 (22)8 (20)12 (29)1 (2)
 Neutropenic fever20 (49)2 (5)16 (39)5 (12)
 Neutropenic infection1 (2)2 (5)1 (2)
Gastrointestinal
 Nausea31 (76)10 (24)23 (56)14 (34)
 Stomatitis21 (51)11 (27)1 (2)26 (63)10 (24)
 Vomiting24 (59)6 (15)24 (59)4 (10)2 (5)
 Diarrhea26 (63)2 (5)19 (46)3 (7)2 (5)
Other
 Fatigue16 (39)25 (61)14 (34)25 (61)
 Myalgia26 (63)13 (32)25 (61)13 (32)
 Neurosensory27 (66)13 (32)28 (68)10 (24)
 Skin reaction16 (39)4 (10)17 (41)1 (2)
 Headache3 (7)2 (5)1 (2)2 (5)
  • a National Cancer Institute Common Toxicity Criteria; includes only toxicity grade ≥3, which was seen in ≥5% of patients.