Table 2

p53, EGFR, mdm2, and Ki-67, and status for LTS GBMs

Individual results are given by case number. Results based on immunohistochemistry are scored as “+” or “−”, except for Ki-67, which is expressed as percentage of positive cells. For the p53 gene, the mutation is represented by showing the mutated codon and amino acid change.

Casep53 proteinp53 geneEGFRmdm2Ki-67
1+codon 266 gly→arg++50.1
2+WTa+22.9
3+WT++31.3
4+codon 152 pro→leu+35.5
5+WT++16.4
6ND5.2
7ND24.0
8+ND3.4
9+ND11.4
10+ND3.8
11+ND16.8
12+ND16.2
13+ND+12.5
14ND15.0
15+ND6.6
16WT+68.1
17+codon 273 arg→cys6.9
18+ND+21.5
19+WT9.5
20+ND12.6
21+ND50.1
22+WT7.8
23+WT+85.2
24+ND4.4
25+WT+56.0
26+ND+4.0
27+WT20.3
28+WT+41.4
29+ND++38.4
30+codon 280 arg→glyND5.9
31ND+12.0
32+WT34.1
33+WT+12.5
34+ND+10.8
35+ND13.5
36+WT+23.0
37+codon 250 arg→cys43.4
38+ND19.0
39+WTND
40+ND+7.9
41WT+15.2
  • a WT, wild type; ND, not determined because of unamplifiable DNA or unavailable slides.