Table 3

Plasma pharmacokinetic parameters of LErafAON in cynomolgus monkeys

Dose (mg/kg)Cmaxa (μg/ml)t1/2α (h)t1/2β (h)AUC0→∞ (μg·h/ml)Cl (L/h/kg)Vd (L/kg)
3.75b0.85 ± 0.630.15 ± 0.0436.39 ± 12.772.35 ± 0.761.74 ± 0.6985.30 ± 7.46
6.25c1.25 ± 0.530.15 ± 0.0830.36 ± 23.875.73 ± 6.301.99 ± 1.2964.72 ± 36.79
  • a Cmax, peak plasma concentration; Vd, volume of distribution.

  • b Values shown are mean ± SD (n = 3, males).

  • c Values shown are mean ± SD (n = 6, three males and three females).