Table 4

HLA phenotyping on confirmed HPV-positive tumor tissue

Patient no.HPV typingaHLA genotyping of tumor cellsbCTL(+) (Virus)c
HLA-AHLA-B
116++++
7+++
1018ND−/+
1116NDNDCTL (HPV-18)
1416++Bw6-veCTL (HPV-16)
1558Bw4-ve
1816/39++++CTL (HPV-16)
2018++++
2316++Bw4-ve
2416++++
2816ND++
  • a HPV typing from tumour sections by PCR (+, positive for HPV but no type specified).

  • b tHLA expression was investigated by immunohistochemistry on frozen and wax-embedded material (−, complete loss of HLA-A or HLA-B locus expression if no alleles indicated).

  • c De novoinduction of HPV-specific CTL (ND, not done).