Table 3

Maximum specific lysis of TA-HPV-infected autologous target cells

PatientStimulationaDay 0bDay 28Day 56Day 84
11RAd 101 13.5 c 5.844.9
RAd 1026.6 10.4 7.14.7
Allogeneic15.510.546.219.6
12RAd 101−2.7ND 27.1 0.8
RAd 102−3.1ND−10.8−4.1
Allogeneic43.9ND45.231.7
14RAd 1017.3ND 22.1 10.9
RAd 1022.8ND1.10.3
Allogeneic10.8ND11.58.1
18RAd 1010.94.6 16.3 4.4
RAd 1023.12.61.22.3
Allogeneic4.964.752.334.9
  • a Restimulation with autologous monocytes infected with recombinant adenovirus containing HPV-16 E6 and E7 (RAd 101) or HPV-18 E6 and E7 (RAd 102) or with allogeneic B-cell lines.

  • b Day after first vaccination when blood sample was taken.

  • c Positive result (shown in bold) with specific lysis ≥ 10% above lysis of control targets at ≥2 E:T ratios. (ND, not done).