Table 3

Serum pharmacokinetics

A three-compartment structural kinetic model with first-order elimination was used to model the serum-time profiles of KRN7000. Data represent mean ± SD. Intercompartmental clearance for the first (Q2) and second (Q3) peripheral compartment were 6.856 liters/h and 0.145 liter/h, respectively. Interpatient variabilities of Q2 and Q3 were not determined in this analysis.

Dose (μg/m2)V1a (liter)Cl (liter/h)V2 (liter)V3 (liter)AUC (ng·h/ml)
501.88 ± 0.730.08 ± 0.031.47 ± 0.601.24 ± 0.481,517 ± 871
1502.88 ± 1.080.14 ± 0.022.75 ± 0.382.24 ± 0.281,934 ± 163
3001.96 ± 0.450.11 ± 0.012.02 ± 0.491.68 ± 0.385,144 ± 449
6002.67 ± 0.760.23 ± 0.134.00 ± 2.133.13 ± 1.556,251 ± 3,940
12002.57 ± 0.700.14 ± 0.043.61 ± 0.672.87 ± 0.4918,137 ± 6,704
24003.33 ± 0.910.20 ± 0.064.67 ± 2.373.61 ± 1.6923,225 ± 6,700
48003.09 ± 1.770.18 ± 0.073.78 ± 2.352.96 ± 1.7154,539 ± 22,020
  • a V1, volume of distribution of the central compartment; Cl, clearance from the central compartment; V2, volume of distribution of the first peripheral compartment; V3, volume of distribution of the second peripheral compartment; AUC, area under the curve per administration.