Table 5

Progression of CINa

StudyBehavior of lesion
% lesions regressed% lesions persisted% lesions progressed to higher grade CIN% lesions progressed to CIS% lesions progressed to ICCb
A. Studies clustered by study design
All grades CIN followed by Pap smear only34.041.025.010.01.0
All grades CIN followed by Pap smear and biopsy45.031.023.014.01.4
CIS followed by biopsyc36.036.0
B. Studies clustered by CIN grade
CIN 157.032.011.0
CIN 243.035.022.0
CIN 332.056.012.0
Overall all grades of CIN1.7
  • a Based on Ostor and Mitchell’s literature reviews (138 , 143) .

  • b ICC, invasive cervical cancer.

  • c —, not available.