Table 1

Metabolic profile of tumor interstitial fluid (TIF), obtained from parental and variant tumors in vivo

All determinations (lactate, pCO2, HCO3, pH, glucose) were performed on the same TIF samples.

Parental tumorsa (ras5B+)Variant tumors (7ras3)Ratio (variant/parental)
Lactateb (mm)22.2 ± 1.3 (20.6–23.6)15.9 ± 1.1 (14.6–18.1)0.72 (P < 0.0002)
pCO2 (mm Hg)76.9 ± 7.9 (64.7–86.0)68.9 ± 9.4 (58.5–85.5)0.90 (P < 0.131)
HCO3 (mm)12.6 ± 0.6 (11.7–13.3)12.0 ± 0.9 (11.0–13.2)0.95 (P < 0.248)
pH6.85 ± 0.05 (6.78–6.92)6.88 ± 0.05 (6.81–6.92)1.00 (P < 0.314)
Glucose (mm)0.63 ± 0.43 (0.54–0.74)0.68 ± 0.34 (0.62–0.80)1.08 (P < 0.274)
  • a Mean ± SD (range); n = 6 animals.

  • b Serum lactate values: 12.8 ± 1.0 mm for parental tumor group; 12.6 ± 0.8 mm for variant tumor group (n = 3 for both).