Table 1

In vitro invasion assay and in vivo proliferation rate of PDX-transfected cells

In vitro invasion assayaIn vivo Mib-1 (Ki67) LIb
U87MGU118MGU87MGU118MG
pCin transfected833 ± 112221 ± 1943 ± 212.5 ± 2.5
pCin.PDX transfected443 ± 3240 ± 818 ± 3.60.5 ± 4
  • a Mean number of cells per filter ± SD. Invasion chambers were used to assess the ability of the cells to degrade ECM. A total of 12 filters (3/clone) were counted (approximately 1000–1600 cells/transfectant clone). One-sided t test indicated significant differences (P < 0.05).

  • b Labeling indices (percentage of Mib-1 (positive cells) in xenotransplanted cells growing in tracheal transplants (at least 500 cells/tracheal transplant were counted). Figures show mean ± SD. One-sided t test indicated significant differences (P < 0.05).