Table 1

Patient characteristics

CharacteristicISIS 3521ISIS 5132Total
Number of patients141630
Median age (range)72 (58–78)66 (52–81)69 (52–81)
Performance status
 010717
 14913
Previous therapy
 Radiation therapy91019
 Surgical castration
 LHRH agonist
Time from diagnosis to study entry
 12–24 months303
 >24 months111627
Sites of disease
 Bone121426
 Lymph nodes4610
 Prostate112
Measurable disease
 Bidimensional4610
 Nonmeasurable101020
Baseline PSA value (ng/ml)
 <50134
 50–99448
 100–199235
 200–399347
 ≥400426