Table 2

Worst hematologic toxicity by patient

ToxicityISIS 3521ISIS 5132
Number of evaluable patients1416
Median nadir (range)
 ANC (×109/liter)2.50 (1.7–3.8)2.65 (1.7–4.0)
 WBC (×109/liter)4.2 (2.8–5.5)4.6 (2.6–5.9)
 Platelet (×109/liter)98 (9–149)129 (48–195)
 Hemoglobin (g/liter)109 (76–131)122 (80–145)
Median number of days to nadir (range)
 ANC43 (8–162)42 (15–83)
 WBC50 (15–162)29 (15–83)
 Platelet22 (14–162)42 (15–136)
 Hemoglobin53 (28–162)50 (8–92)