Table 3

Pathological features of precursor lesions and pancreatic cancer in p16-Leiden mutation carriers

Expression of Tp53: I, no expression (<1% positive); II, low expression (1% less than positive-stained nuclei <25%); III, moderate expression (25% less than positive-stained nuclei <75%); and IV, high expression (>75% positive). The immunoreactivity score for COX-2 was divided into four categories: absent; weak (1+); moderate (2+); and strong (3+). A score of ≥2+ was considered as positive (overexpression).

No.TissueHistologyT percentageLOHK-ras-2IHC
p16Tp53Smad4COX-2
1WhipplePanIN-Ia and Ib50NoGAT (1×)+2+
CDANoGAT1+
3WhipplePanIN-Ia40NoGAT2+1 +
PanIN-IINoGAT/AGT/GCTNA2+Pos
CDANoGAT1+Pos
4Pancreas bpPanIN-Ia and IINANAa+2NANA
CDAb4+Pos
9AutopsyPanIN-IaNANA2+1 +
NC>40NoGTT2Pos
  • a NA, not analyzed; NC, neuroendocrine carcinoma; Pos, positive.

  • b Only few tumor cells.