Table 2

Distribution of morphological characteristics in familial breast cancer

BRCA1 n (%)PBRCA(−) n (%)PBRCA2 n (%)
Histological type
 IDC19 (95.0)29 (78.4)15 (83.3)
 DCIS1 (5.0)5 (13.5)2 (11.1)
 ILC0NS3 (8.1)NS1 (5.6)
Gradea
 1014 (50)1 (7.1)
 23 (15.8)8 (28.6)5 (35.7)
 316 (84.2)<0.00016 (21.4)0.0148 (57.1)
Tubule scorea
 11 (5.3)9 (32.2)0
 23 (15.8)6 (21.4)5 (35.7)
 315 (78.9)0.04913 (46.4)NS (0.055)9 (64.3)
Mitotic counta
 12 (10.5)17 (60.7)4 (28.6)
 22 (10.5)6 (21.4)2 (14.3)
 315 (78.9)<0.00015 (17.9)0.0338 (57.1)
Pleomorphism scorea
 103 (10.7)0
 22 (10.5)16 (57.1)5 (35.7)
 317 (89.5)0.0019 (32.1)NS (0.09)9 (64.3)
  • a Only including the infiltrating ductal tumors. NS, not statistically significant.