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Read the August 15 issue!
The cover shows a section of the bone marrow biopsy from a patient with primary myelofibrosis. Reticulin staining shows diffusely increased bone marrow fibrosis, a hallmark of the disease pathology. See article by Gangat, et al.
$Multicenter Phase I Study of Erdafitinib (JNJ-42756493), Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients with Advanced or Refractory Solid Tumors$
Clinical Trials: Targeted Therapy
Read: Multicenter Phase I Study of Erdafitinib (JNJ-42756493), Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients with Advanced or Refractory Solid Tumors, Rastislav Bahleda, et al.
CCR Translations
Read: When Cancer Vaccines Go Viral, David Repáraz, et al.

From the Current Issue

Clinical Trials: Targeted Therapy

Multicenter Phase I Study of Erdafitinib (JNJ-42756493), Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients with Advanced or Refractory Solid Tumors

Rastislav Bahleda, Antoine Italiano, Cinta Hierro, Alain Mita, Andres Cervantes, Nancy Chan, Mark Awad, Emiliano Calvo, Victor Moreno, Ramaswamy Govindan, Alexander Spira, Martha Gonzalez, Bob Zhong, Ademi Santiago-Walker, Italo Poggesi, Trilok Parekh, Hong Xie, Jeffrey Infante and Josep Tabernero

Clin Cancer Res August 15 2019 25 (16) 4888-4897; DOI:10.1158/1078-0432.CCR-18-3334
Clinical Trials: Targeted Therapy

Aurora Kinase A Inhibition Provides Clinical Benefit, Normalizes Megakaryocytes, and Reduces Bone Marrow Fibrosis in Patients with Myelofibrosis: A Phase I Trial

Naseema Gangat, Christian Marinaccio, Ronan Swords, Justin M. Watts, Sandeep Gurbuxani, Alfred Rademaker, Angela J. Fought, Olga Frankfurt, Jessica K. Altman, Qiang Jeremy Wen, Noushin Farnoud, Christopher A. Famulare, Akshar Patel, Roberto Tapia, Rangit R. Vallapureddy, Stephanie Barath, Amy Graf, Amy Handlogten, Darci Zblewski, Mrinal M. Patnaik, Aref Al-kali, Yvonne Trang Dinh, Kristen Englund Prahl, Shradha Patel, Juan Carlos Nobrega, Dalissa Tejera, Amber Thomassen, Juehua Gao, Peng Ji, Raajit K. Rampal, Francis J. Giles, Ayalew Tefferi, Brady Stein and John D. Crispino

Clin Cancer Res August 15 2019 25 (16) 4898-4906; DOI:10.1158/1078-0432.CCR-19-1005
Clinical Trials: Immunotherapy

A Phase I Dose-Escalation Trial of BN-CV301, a Recombinant Poxviral Vaccine Targeting MUC1 and CEA with Costimulatory Molecules

Margaret E. Gatti-Mays, Julius Strauss, Renee N. Donahue, Claudia Palena, Jaydira Del Rivero, Jason M. Redman, Ravi A. Madan, Jennifer L. Marté, Lisa M. Cordes, Elizabeth Lamping, Alanvin Orpia, Andrea Burmeister, Eva Wagner, Cesar Pico Navarro, Christopher R. Heery, Jeffrey Schlom and James L. Gulley

Clin Cancer Res August 15 2019 25 (16) 4933-4944; DOI:10.1158/1078-0432.CCR-19-0183
Precision Medicine and Imaging

Circulating Tumor DNA as a Clinical Test in Resected Pancreatic Cancer

Vincent P. Groot, Stacy Mosier, Ammar A. Javed, Jonathan A. Teinor, Georgios Gemenetzis, Ding Ding, Lisa M. Haley, Jun Yu, Richard A. Burkhart, Alina Hasanain, Marija Debeljak, Hirohiko Kamiyama, Amol Narang, Daniel A. Laheru, Lei Zheng, Ming-Tseh Lin, Christopher D. Gocke, Elliot K. Fishman, Ralph H. Hruban, Michael G. Goggins, I. Quintus Molenaar, John L. Cameron, Matthew J. Weiss, Victor E. Velculescu, Jin He, Christopher L. Wolfgang and James R. Eshleman

Clin Cancer Res August 15 2019 25 (16) 4973-4984; DOI:10.1158/1078-0432.CCR-19-0197

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