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Correlation of Osteopontin Protein Expression and Pathological Stage across a Wide Variety of Tumor Histologies

Domenico Coppola, Marianna Szabo, David Boulware, Patrick Muraca, Marwan Alsarraj, Ann F. Chambers and Timothy J. Yeatman
Domenico Coppola
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Marianna Szabo
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David Boulware
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Patrick Muraca
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Marwan Alsarraj
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Ann F. Chambers
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Timothy J. Yeatman
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DOI: 10.1158/1078-0432.CCR-1405-2 Published January 2004
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    Fig. 1.

    Breast ductal carcinoma expressing low levels of OPN (A) is compared with normal breast tissue showing only faint and focal OPN stain (A1). High cytoplasmic OPN expression is shown in cases of ovarian papillary serous cystadenocarcinoma (B), endometrial adenocarcinoma (C), gastric adenocarcinoma (D), colon adenocarcinoma (E), pancreatic ductal carcinoma (F), renal cell carcinoma (I), transitional cell carcinoma of bladder (J), squamous cell carcinoma of the mouth (L), squamous cell carcinoma of the lung (M), and adenocarcinoma of the lung (N). OPN was not detected in hepatocellular carcinoma (G), bronchioloalveolar carcinoma of the lung (M1), or in normal prostatic tissue (K1). In H is a renal pelvis transitional cell carcinoma showing low OPN stain (×400).

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    Fig. 2.

    Progressive increase in OPN expression in different stages of colon adenocarcinoma. Low expression of OPN is noted in adenoma (A) and in stage I (T1N0M0) cancer (B). In A, the normal colonic mucosa adjacent to the adenoma is OPN negative. The increasing degree of staining intensity is noted from stage IIA (T3N0M0) to stage IIIB (T4N1M0) to stage IV (T3N1M1) adenocarcinoma. Tumors were staged according to the Tumor-Node-Metastasis system, following the recommendations of the American Joint Committee on Cancer, 1992.

Tables

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  • Table 1

    Results of immunohistochemical analyses for both tumor and normal tissues

    Tumor typeNumberOPNa Allred score
    01 to 34 to 67 to 8
    Bile duct10010
    Bladder3396117
    Brain102260
    Breast2615830
    Colon201298
    Endometrium142246
    Esophagus SCC102161
    Kidney3682197
    Larynx SCC31110
    Lip SCC91134
    Liver95040
    Lung1723111
    Mouth SCC1934102
    Ovarian227285
    Pancreas162149
    Pharynx SCC52120
    Prostate2897102
    Renal pelvis1721140
    Salivary gland1410130
    Skin64011
    Stomach110065
    Thyroid22000
    Tongue SCC2253131
    Total tumors350944814959
    Normal tissues1135127287
    • a OPN, osteopontin; SCC, squamous cell carcinoma.

  • Table 2

    Correlation of OPN protein expression and tumor stage

    SiteSpearman correlation (rs)NP value
    All sites0.2133110.0002
    Male0.2181970.0021
    Female0.2141140.0224
    65 and under0.161660.039
    Over 650.271450.001
    Bile duct1
    Bladder0.432330.012
    Brain10
    Breast0.090210.699
    Colon0.619200.004
    Endometrium0.318140.268
    Esophagus3
    Kidney0.641310.0001
    Larynx0.586130.0352
    Lipa9
    Liver9
    Lung0.025170.923
    Mouth−0.462190.046
    Ovary0.412220.057
    Pancreas0.281110.403
    Pharynx0.23640.764
    Prostatea28
    Renal pelvis.084160.76
    Salivary0.654140.011
    Skin1
    Stomach−0.058110.865
    Thyroid2
    Tongue0.305220.167
    • a All of the observations in this site had the same stage value, making a valid correlation impossible.

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Clinical Cancer Research: 10 (1)
January 2004
Volume 10, Issue 1
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Correlation of Osteopontin Protein Expression and Pathological Stage across a Wide Variety of Tumor Histologies
Domenico Coppola, Marianna Szabo, David Boulware, Patrick Muraca, Marwan Alsarraj, Ann F. Chambers and Timothy J. Yeatman
Clin Cancer Res January 1 2004 (10) (1) 184-190; DOI: 10.1158/1078-0432.CCR-1405-2

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Correlation of Osteopontin Protein Expression and Pathological Stage across a Wide Variety of Tumor Histologies
Domenico Coppola, Marianna Szabo, David Boulware, Patrick Muraca, Marwan Alsarraj, Ann F. Chambers and Timothy J. Yeatman
Clin Cancer Res January 1 2004 (10) (1) 184-190; DOI: 10.1158/1078-0432.CCR-1405-2
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