Article Figures & Data
Figures
- Fig. 1.
Schematics showing maturation of mesothelin protein. Precursor protein for mesothelin is synthesized as a 622-amino acid polypeptide with a calculated molecular mass of 77 kDa. The potential signal peptide (SP) and the glycosylphosphatidyl inositol anchor signal sequence (GASS) are predicted at the NH2 terminus and the COOH terminus, respectively. The precursor protein has four predicted glycosylation sites (CHO) and a furin cleavage site (RR). Cleavage at the furin site generates membrane-bound mesothelin (green) and the secretory protein megakaryocyte-potentiating factor (red).
- Fig. 2.
Schematics describing the mesothelin gene and the proteins it encodes. A, genomic organization of mesothelin gene. There are 17 exons (filled boxes) in the mesothelin gene. B, drawing of three different forms of mesothelin protein described in the database. Mesothelin is the most common variant and is predicted to be membrane-bound; mesothelin V-1 has an additional 8 amino acids (yellow) and is also predicted to be bound to the membrane. Mesothelin V-2 has a modified COOH terminus (orange), lacks the glycosylphosphatidyl inositol anchor signal sequence, and is predicted to be secreted.
Volume 10, Issue 12
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- Article
- Abstract
- INTRODUCTION
- ISOLATION OF MAB K1 AND CLONING OF ITS 40-KDA ANTIGEN, MESOTHELIN
- MPF
- SOLUBLE MESOTHELIN
- BIOLOGICAL FUNCTION OF MESOTHELIN
- MESOTHELIN EXPRESSION IN HUMAN MALIGNANCIES
- MESOTHELIN AS A TARGET FOR TUMOR- SPECIFIC IMMUNOTHERAPY
- CLINICAL TRIALS OF SS1(DSFV)-PE38 (SS1P)
- MESOTHELIN AS A THERAPEUTIC CANCER VACCINE
- SOLUBLE MESOTHELIN AS A DIAGNOSTIC TUMOR MARKER
- MESOTHELIN IMMUNOHISTOCHEMISTRY FOR TUMOR DIAGNOSIS
- CONCLUSION
- Acknowledgments
- Footnotes
- References
- Figures & Data
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