Table of Contents

Regular Articles

• Clinical Trials

  • Regular Articles

    The Effects of Standard Anthracycline-Based Chemotherapy on Soluble ICAM-1 and Vascular Endothelial Growth Factor Levels in Breast Cancer

    Paul J. Mills, Barbara Parker, Vicky Jones, Karen A. Adler, Christy J. Perez, Sherella Johnson, Mairav Cohen-Zion, Matthew Marler, Georgia R. Sadler, Joel E. Dimsdale and Sonia Ancoli-Israel

    Clin Cancer Res August 1 2004 10 (15) 4998-5003; DOI:10.1158/1078-0432.CCR-0734-04

    
    
  • Regular Articles

    Immune Responses to a Class II Helper Peptide Epitope in Patients with Stage III/IV Resected Melanoma

    Raymond Wong, Roy Lau, Jenny Chang, Tina Kuus-Reichel, Vincent Brichard, Claudine Bruck and Jeffrey Weber

    Clin Cancer Res August 1 2004 10 (15) 5004-5013; DOI:10.1158/1078-0432.CCR-04-0241

    
    
  • Regular Articles

    Pilot Trial Evaluating an ¹²³I-Labeled 80-Kilodalton Engineered Anticarcinoembryonic Antigen Antibody Fragment (cT84.66 Minibody) in Patients with Colorectal Cancer

    Jeffrey Y. C. Wong, David Z. Chu, Lawrence E. Williams, Dave M. Yamauchi, David N. Ikle, Cheuk S. Kwok, An Liu, Sharon Wilczynski, David Colcher, Paul J. Yazaki, John E. Shively, Anna M. Wu and Andrew A. Raubitschek

    Clin Cancer Res August 1 2004 10 (15) 5014-5021; DOI:10.1158/1078-0432.CCR-03-0576

    
    
  • Regular Articles

    Randomized Phase II Trial of Sequential Chemotherapy in Advanced Non-Small Cell Lung Cancer (SWOG 9806)

    Martin J. Edelman, Joseph I. Clark, Kari Chansky, Kathy Albain, Nirmala Bhoopalam, Geoffrey R. Weiss, Jeffrey K. Giguere, Karen Kelly, John Crowley and David R. Gandara

    Clin Cancer Res August 1 2004 10 (15) 5022-5026; DOI:10.1158/1078-0432.CCR-04-0002

    
    
  • Regular Articles

    A Phase I Study of Interleukin 12 with Trastuzumab in Patients with Human Epidermal Growth Factor Receptor-2-Overexpressing Malignancies

    Robin Parihar, Padma Nadella, Adrian Lewis, Rhonda Jensen, Carrie De Hoff, Julie E. Dierksheide, Anne M. VanBuskirk, Cynthia M. Magro, Donn C. Young, Charles L. Shapiro and William E. Carson III

    Clin Cancer Res August 1 2004 10 (15) 5027-5037; DOI:10.1158/1078-0432.CCR-04-0265

    
    
  • Regular Articles

    Phase I Trial of the Cyclin-Dependent Kinase Inhibitor Flavopiridol in Combination with Docetaxel in Patients with Metastatic Breast Cancer

    Antoinette R. Tan, Xiaowei Yang, Arlene Berman, Suoping Zhai, Alex Sparreboom, Allyson L. Parr, Catherine Chow, Jaime S. Brahim, Seth M. Steinberg, William D. Figg and Sandra M. Swain

    Clin Cancer Res August 1 2004 10 (15) 5038-5047; DOI:10.1158/1078-0432.CCR-04-0025

    
    
  • Regular Articles

    A Phase I Pharmacokinetic and Biological Correlative Study of Oblimersen Sodium (Genasense, G3139), an Antisense Oligonucleotide to the Bcl-2 mRNA, and of Docetaxel in Patients with Hormone-Refractory Prostate Cancer

    Anthony W. Tolcher, John Kuhn, Garry Schwartz, Amita Patnaik, Lisa A. Hammond, Ian Thompson, Howard Fingert, David Bushnell, Shazli Malik, Jeffrey Kreisberg, Elzbieta Izbicka, Leslie Smetzer and Eric K. Rowinsky

    Clin Cancer Res August 1 2004 10 (15) 5048-5057; DOI:10.1158/1078-0432.CCR-03-0701

    
    
  • Regular Articles

    Phase I and Pharmacologic Study of Intermittently Administered 9-Nitrocamptothecin in Patients with Advanced Solid Tumors

    William C. Zamboni, Laura L. Jung, Merrill J. Egorin, Douglas M. Potter, David M. Friedland, Chandra P. Belani, Sanjiv S. Agarwala, Michael M. W. Wong, Marwan Fakih, Donald L. Trump, Ruzhi Jin, Sandra Strychor, Michael Vozniak, Monica Troetschel and Ramesh K. Ramanathan

    Clin Cancer Res August 1 2004 10 (15) 5058-5064; DOI:10.1158/1078-0432.CCR-03-0288

    
    
  • Regular Articles

    Extended Follow-up of Patients Treated with Imatinib Mesylate (Gleevec) for Chronic Myelogenous Leukemia Relapse after Allogeneic Transplantation

    Daniel J. DeAngelo, Ephraim P. Hochberg, Edwin P. Alyea, Janina Longtine, Stephanie Lee, Ilene Galinsky, Ben Parekkedon, Jerome Ritz, Joseph H. Antin, Richard M. Stone and Robert J. Soiffer

    Clin Cancer Res August 1 2004 10 (15) 5065-5071; DOI:10.1158/1078-0432.CCR-03-0580

    
    
  • Regular Articles

    Pharmacokinetics of O⁶-benzylguanine in Pediatric Patients with Central Nervous System Tumors

    Kathleen Neville, Susan Blaney, Mark Bernstein, Patrick Thompson, Denise Adams, Alexander Aleksic and Stacey Berg

    Clin Cancer Res August 1 2004 10 (15) 5072-5075; DOI:10.1158/1078-0432.CCR-03-0123

    
    

• Molecular Oncology, Markers, Clinical Correlates

  • Regular Articles

    Prognostic Analysis of Early Lymphocyte Recovery in Patients with Advanced Breast Cancer Receiving High-Dose Chemotherapy with an Autologous Hematopoietic Progenitor Cell Transplant

    Yago Nieto, Elizabeth J. Shpall, Ian K. McNiece, Samia Nawaz, Julie Beaudet, Steve Rosinski, Julie Pellom, Victoria Slat-Vasquez, Peter A. McSweeney, Scott I. Bearman, James Murphy and Roy B. Jones

    Clin Cancer Res August 1 2004 10 (15) 5076-5086; DOI:10.1158/1078-0432.CCR-04-0117

    
    
  • Regular Articles

    Methylation of p16 CpG Islands Associated with Malignant Transformation of Gastric Dysplasia in a Population-Based Study

    Yu Sun, Dajun Deng, Wei-Cheng You, Hua Bai, Lian Zhang, Jing Zhou, Lin Shen, Jun-Ling Ma, Yu-Quan Xie and Ji-You Li

    Clin Cancer Res August 1 2004 10 (15) 5087-5093; DOI:10.1158/1078-0432.CCR-03-0622

    
    
  • Regular Articles

    B7-H1 Expression on Non-Small Cell Lung Cancer Cells and Its Relationship with Tumor-Infiltrating Lymphocytes and Their PD-1 Expression

    Jun Konishi, Koichi Yamazaki, Miyuki Azuma, Ichiro Kinoshita, Hirotoshi Dosaka-Akita and Masaharu Nishimura

    Clin Cancer Res August 1 2004 10 (15) 5094-5100; DOI:10.1158/1078-0432.CCR-04-0428

    
    
  • Regular Articles

    Expression of Pro- and Antiapoptotic Proteins in Circulating CD8+ T Cells of Patients with Squamous Cell Carcinoma of the Head and Neck

    Jeong-Whun Kim, Takashi Tsukishiro, Jonas T. Johnson and Theresa L. Whiteside

    Clin Cancer Res August 1 2004 10 (15) 5101-5110; DOI:10.1158/1078-0432.CCR-04-0309

    
    
  • Regular Articles

    Primary Acute Lymphoblastic Leukemia Cells Use a Novel Promoter and 5′Noncoding Exon for the Human Reduced Folate Carrier That Encodes a Modified Carrier Translated from an Upstream Translational Start

    Robin M. Flatley, Scott G. Payton, Jeffrey W. Taub and Larry H. Matherly

    Clin Cancer Res August 1 2004 10 (15) 5111-5122; DOI:10.1158/1078-0432.CCR-04-0116

    
    
  • Regular Articles

    Elevated S-Phase Kinase-Associated Protein 2 Protein Expression in Acute Myelogenous Leukemia

    Yoo Hong Min, June-Won Cheong, Mark Hong Lee, Ji Yeon Kim, Seung Tae Lee, Jee Sook Hahn and Yun Woong Ko

    Clin Cancer Res August 1 2004 10 (15) 5123-5130; DOI:10.1158/1078-0432.CCR-04-0136

    
    
  • Regular Articles

    Promoter Hypermethylation of Resected Bronchial Margins

    Mingzhou Guo, Michael G. House, Craig Hooker, Yu Han, Elizabeth Heath, Edward Gabrielson, Stephen C. Yang, Stephen B. Baylin, James G. Herman and Malcolm V. Brock

    Clin Cancer Res August 1 2004 10 (15) 5131-5136; DOI:10.1158/1078-0432.CCR-03-0763

    
    
  • Regular Articles

    Expression of Vascular Endothelial Growth Factor Receptor-3 by Lymphatic Endothelial Cells Is Associated with Lymph Node Metastasis in Prostate Cancer

    Yiping Zeng, Kenneth Opeskin, Megan E. Baldwin, Lisa G. Horvath, Marc G. Achen, Steven A. Stacker, Robert L. Sutherland and Elizabeth D. Williams

    Clin Cancer Res August 1 2004 10 (15) 5137-5144; DOI:10.1158/1078-0432.CCR-03-0434

    
    
  • Regular Articles

    EphA2 Expression Is Associated with Aggressive Features in Ovarian Carcinoma

    Premal H. Thaker, Michael Deavers, Joseph Celestino, Angela Thornton, Mavis S. Fletcher, Charles N. Landen, Michael S. Kinch, Peter A. Kiener and Anil K. Sood

    Clin Cancer Res August 1 2004 10 (15) 5145-5150; DOI:10.1158/1078-0432.CCR-03-0589

    
    
  • Regular Articles

    Relevance of Different UGT1A1 Polymorphisms in Irinotecan-Induced Toxicity

    Elisabeth Rouits, Michèle Boisdron-Celle, Agnès Dumont, Olivier Guérin, Alain Morel and Erick Gamelin

    Clin Cancer Res August 1 2004 10 (15) 5151-5159; DOI:10.1158/1078-0432.CCR-03-0548

    
    
  • Regular Articles

    Patterns of Chromosomal Alterations in Breast Ductal Carcinoma In situ

    E. Shelley Hwang, Sandy DeVries, Karen L. Chew, Dan H. Moore II, Karla Kerlikowske, Ann Thor, Britt-Marie Ljung and Frederic M. Waldman

    Clin Cancer Res August 1 2004 10 (15) 5160-5167; DOI:10.1158/1078-0432.CCR-04-0165

    
    
  • Regular Articles

    Cyclin D1, p53, and p21^Waf1/Cip1 Expression Is Predictive of Poor Clinical Outcome in Serous Epithelial Ovarian Cancer

    Anish Bali, Philippa M. O’Brien, Lyndal S. Edwards, Robert L. Sutherland, Neville F. Hacker and Susan M. Henshall

    Clin Cancer Res August 1 2004 10 (15) 5168-5177; DOI:10.1158/1078-0432.CCR-03-0751

    
    
  • Regular Articles

    Distribution and Clinical Significance of Heparan Sulfate Proteoglycans in Ovarian Cancer

    E. June Davies, Fiona H. Blackhall, Jonathan H. Shanks, Guido David, Alan T. McGown, Ric Swindell, Richard J. Slade, Pierre Martin-Hirsch, John T. Gallagher and Gordon C. Jayson

    Clin Cancer Res August 1 2004 10 (15) 5178-5186; DOI:10.1158/1078-0432.CCR-03-0103

    
    

• Experimental Therapeutics, Preclinical Pharmacology

  • Regular Articles

    Noscapine Crosses the Blood-Brain Barrier and Inhibits Glioblastoma Growth

    Jaren W. Landen, Vincent Hau, Mingshen Wang, Thomas Davis, Brian Ciliax, Bruce H. Wainer, Erwin G. Van Meir, Johnathan D. Glass, Harish C. Joshi and David R. Archer

    Clin Cancer Res August 1 2004 10 (15) 5187-5201; DOI:10.1158/1078-0432.CCR-04-0360

    
    
  • Regular Articles

    CD95-Mediated Apoptosis Is Impaired at Receptor Level by Cellular FLICE-Inhibitory Protein (Long Form) in Wild-Type p53 Human Ovarian Carcinoma

    Delia Mezzanzanica, Emanuela Balladore, Fabio Turatti, Elena Luison, Paola Alberti, Marina Bagnoli, Mariangela Figini, Alessandra Mazzoni, Francesco Raspagliesi, Maria Oggionni, Silvana Pilotti and Silvana Canevari

    Clin Cancer Res August 1 2004 10 (15) 5202-5214; DOI:10.1158/1078-0432.CCR-03-0537

    
    
  • Regular Articles

    Mifepristone Induces Growth Arrest, Caspase Activation, and Apoptosis of Estrogen Receptor-Expressing, Antiestrogen-Resistant Breast Cancer Cells

    Virgil T. Gaddy, John T. Barrett, Jennifer N. Delk, Andre M. Kallab, Alan G. Porter and Patricia V. Schoenlein

    Clin Cancer Res August 1 2004 10 (15) 5215-5225; DOI:10.1158/1078-0432.CCR-03-0637

    
    
  • Regular Articles

    The Effect of Megestrol Acetate on Growth of HepG2 Cells In vitro and In vivo

    Kai Zhang and Pierce K. H. Chow

    Clin Cancer Res August 1 2004 10 (15) 5226-5232; DOI:10.1158/1078-0432.CCR-04-0061

    
    
  • Regular Articles

    Pharmacokinetics and Tissue Disposition of Indole-3-carbinol and Its Acid Condensation Products after Oral Administration to Mice

    Mark J. Anderton, Margaret M. Manson, Richard D. Verschoyle, Andreas Gescher, John H. Lamb, Peter B. Farmer, William P. Steward and Marion L. Williams

    Clin Cancer Res August 1 2004 10 (15) 5233-5241; DOI:10.1158/1078-0432.CCR-04-0163

    
    
  • Regular Articles

    In vitro Combination Treatment with Perifosine and UCN-01 Demonstrates Synergism against Prostate (PC-3) and Lung (A549) Epithelial Adenocarcinoma Cell Lines

    Girija P. Dasmahapatra, Parijat Didolkar, Michael C. Alley, Somiranjan Ghosh, Edward A. Sausville and Krishnendu K. Roy

    Clin Cancer Res August 1 2004 10 (15) 5242-5252; DOI:10.1158/1078-0432.CCR-03-0534

    
    
  • Regular Articles

    trans-3,4,5′-Trihydroxystibene Inhibits Hypoxia-Inducible Factor 1α and Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells

    Zongxian Cao, Jing Fang, Chang Xia, Xianglin Shi and Bing-Hua Jiang

    Clin Cancer Res August 1 2004 10 (15) 5253-5263; DOI:10.1158/1078-0432.CCR-03-0588

    
    
  • Regular Articles

    Nitric Oxide Accelerates Interleukin-13 Cytotoxin-Mediated Regression in Head and Neck Cancer Animal Model

    Koji Kawakami, Mariko Kawakami and Raj K. Puri

    Clin Cancer Res August 1 2004 10 (15) 5264-5270; DOI:10.1158/1078-0432.CCR-04-0314

    
    
  • Regular Articles

    Class I Histone Deacetylase-Selective Novel Synthetic Inhibitors Potently Inhibit Human Tumor Proliferation

    Jung-Hyun Park, Yeonjoo Jung, Tai Young Kim, Sang Gyun Kim, Hyun-Soon Jong, Jung Weon Lee, Dae-Kee Kim, Jong-Soo Lee, Noe Kyeong Kim, Tae-You Kim and Yung-Jue Bang

    Clin Cancer Res August 1 2004 10 (15) 5271-5281; DOI:10.1158/1078-0432.CCR-03-0709

    
    
  • Regular Articles

    A Concentrated Aglycone Isoflavone Preparation (GCP) That Demonstrates Potent Anti-Prostate Cancer Activity In vitro and In vivo

    Debra L. Bemis, Jillian L. Capodice, Manisha Desai, Ralph Buttyan and Aaron E. Katz

    Clin Cancer Res August 1 2004 10 (15) 5282-5292; DOI:10.1158/1078-0432.CCR-03-0828