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Table of Contents

Perspective

  • Perspective
    The Potential Role of Neutrophils in Promoting the Metastatic Phenotype of Tumors Releasing Interleukin-8
    Joseph E. De Larco, Beverly R. K. Wuertz and Leo T. Furcht
    Clin Cancer Res August 1 2004 10 (15) 4895-4900; DOI:10.1158/1078-0432.CCR-03-0760

Review

  • Review
    Biological Relevance of Adduct Detection to the Chemoprevention of Cancer
    Ricky A. Sharma and Peter B. Farmer
    Clin Cancer Res August 1 2004 10 (15) 4901-4912; DOI:10.1158/1078-0432.CCR-04-0098

Featured Articles

  • Clinical Trials

    • Featured Articles
      Phase I and Pharmacokinetic Study of the Oral Fluoropyrimidine S-1 on a Once-Daily-for-28-Day Schedule in Patients with Advanced Malignancies
      Quincy Siu-Chung Chu, Lisa A. Hammond, Garry Schwartz, Leonel Ochoa, Sun-Young Rha, Louis Denis, Kathleen Molpus, Brian Roedig, Stephen P. Letrent, Bharat Damle, Arthur P. DeCillis and Eric K. Rowinsky
      Clin Cancer Res August 1 2004 10 (15) 4913-4921; DOI:10.1158/1078-0432.CCR-04-0469

    • Featured Articles
      Phase I Study of Concomitant Chemoradiotherapy with Paclitaxel, Fluorouracil, Gemcitabine, and Twice-Daily Radiation in Patients with Poor-Prognosis Cancer of the Head and Neck
      Michael T. Milano, Daniel J. Haraf, Kerstin M. Stenson, Mary Ellyn Witt, Cathy Eng, Bharat B. Mittal, Athanassios Argiris, Harold Pelzer, Mark F. Kozloff and Everett E. Vokes
      Clin Cancer Res August 1 2004 10 (15) 4922-4932; DOI:10.1158/1078-0432.CCR-03-0634

  • Molecular Oncology, Markers, Clinical Correlates

    • Featured Articles
      CpG Island Hypermethylation of the DNA Repair Enzyme Methyltransferase Predicts Response to Temozolomide in Primary Gliomas
      Maria F. Paz, Ricard Yaya-Tur, Iñigo Rojas-Marcos, Gaspar Reynes, Marina Pollan, Lucinda Aguirre-Cruz, Jose Luis García-Lopez, Jose Piquer, María-Jose Safont, Carmen Balaña, Montserrat Sanchez-Cespedes, Mercedes García-Villanueva, Leoncio Arribas and Manel Esteller
      Clin Cancer Res August 1 2004 10 (15) 4933-4938; DOI:10.1158/1078-0432.CCR-04-0392

    • Featured Articles
      Excision Repair Cross-Complementation Group 1 Polymorphism Predicts Overall Survival in Advanced Non-Small Cell Lung Cancer Patients Treated With Platinum-Based Chemotherapy
      Wei Zhou, Sarada Gurubhagavatula, Geoffrey Liu, Sohee Park, Donna S. Neuberg, John C. Wain, Thomas J. Lynch, Li Su and David C. Christiani
      Clin Cancer Res August 1 2004 10 (15) 4939-4943; DOI:10.1158/1078-0432.CCR-04-0247

    • Featured Articles
      Global Gene Expression Profile of Nasopharyngeal Carcinoma by Laser Capture Microdissection and Complementary DNA Microarrays
      Virote Sriuranpong, Apiwat Mutirangura, John W. Gillespie, Vyomesh Patel, Panomwat Amornphimoltham, Alfredo A. Molinolo, Veerachai Kerekhanjanarong, Siripornchai Supanakorn, Pakpoom Supiyaphun, Samreung Rangdaeng, Narin Voravud and J. Silvio Gutkind
      Clin Cancer Res August 1 2004 10 (15) 4944-4958; DOI:10.1158/1078-0432.CCR-03-0757

    • Featured Articles
      Imiquimod Treatment Induces Expression of Opioid Growth Factor Receptor
      Mirjana Urosevic, Patrick A. Oberholzer, Tanja Maier, Jürg Hafner, Elisabeth Laine, Herbert Slade, Bernd Benninghoff, Günter Burg and Reinhard Dummer
      Clin Cancer Res August 1 2004 10 (15) 4959-4970; DOI:10.1158/1078-0432.CCR-04-0193

    • Featured Articles
      Expression Profiling of T-Cell Lymphomas Differentiates Peripheral and Lymphoblastic Lymphomas and Defines Survival Related Genes
      Beatriz Martinez-Delgado, Barbara Meléndez, Marta Cuadros, Javier Alvarez, Jose Maria Castrillo, Ana Ruiz de la Parte, Manuela Mollejo, Carmen Bellas, Ramon Diaz, Luis Lombardía, Fatima Al-Shahrour, Orlando Domínguez, Alberto Cascon, Mercedes Robledo, Carmen Rivas and Javier Benitez
      Clin Cancer Res August 1 2004 10 (15) 4971-4982; DOI:10.1158/1078-0432.CCR-04-0269

  • Experimental Therapeutics, Preclinical Pharmacology

    • Featured Articles
      Antitumor Activity of Systemically Delivered Ribozymes Targeting Murine Telomerase RNA
      Mehdi Nosrati, Shang Li, Sepideh Bagheri, David Ginzinger, Elizabeth H. Blackburn, Robert J. Debs and Mohammed Kashani-Sabet
      Clin Cancer Res August 1 2004 10 (15) 4983-4990; DOI:10.1158/1078-0432.CCR-04-0134

    • Featured Articles
      Superior Activity of the Combination of Histone Deacetylase Inhibitor LAQ824 and the FLT-3 Kinase Inhibitor PKC412 against Human Acute Myelogenous Leukemia Cells with Mutant FLT-3
      Purva Bali, Prince George, Pamela Cohen, Jianguo Tao, Fei Guo, Celia Sigua, Anasuya Vishvanath, Anna Scuto, Srinivas Annavarapu, Warren Fiskus, Lynn Moscinski, Peter Atadja and Kapil Bhalla
      Clin Cancer Res August 1 2004 10 (15) 4991-4997; DOI:10.1158/1078-0432.CCR-04-0210

Regular Articles

  • Clinical Trials

    • Regular Articles
      The Effects of Standard Anthracycline-Based Chemotherapy on Soluble ICAM-1 and Vascular Endothelial Growth Factor Levels in Breast Cancer
      Paul J. Mills, Barbara Parker, Vicky Jones, Karen A. Adler, Christy J. Perez, Sherella Johnson, Mairav Cohen-Zion, Matthew Marler, Georgia R. Sadler, Joel E. Dimsdale and Sonia Ancoli-Israel
      Clin Cancer Res August 1 2004 10 (15) 4998-5003; DOI:10.1158/1078-0432.CCR-0734-04

    • Regular Articles
      Immune Responses to a Class II Helper Peptide Epitope in Patients with Stage III/IV Resected Melanoma
      Raymond Wong, Roy Lau, Jenny Chang, Tina Kuus-Reichel, Vincent Brichard, Claudine Bruck and Jeffrey Weber
      Clin Cancer Res August 1 2004 10 (15) 5004-5013; DOI:10.1158/1078-0432.CCR-04-0241

    • Regular Articles
      Pilot Trial Evaluating an 123I-Labeled 80-Kilodalton Engineered Anticarcinoembryonic Antigen Antibody Fragment (cT84.66 Minibody) in Patients with Colorectal Cancer
      Jeffrey Y. C. Wong, David Z. Chu, Lawrence E. Williams, Dave M. Yamauchi, David N. Ikle, Cheuk S. Kwok, An Liu, Sharon Wilczynski, David Colcher, Paul J. Yazaki, John E. Shively, Anna M. Wu and Andrew A. Raubitschek
      Clin Cancer Res August 1 2004 10 (15) 5014-5021; DOI:10.1158/1078-0432.CCR-03-0576

    • Regular Articles
      Randomized Phase II Trial of Sequential Chemotherapy in Advanced Non-Small Cell Lung Cancer (SWOG 9806)
      Martin J. Edelman, Joseph I. Clark, Kari Chansky, Kathy Albain, Nirmala Bhoopalam, Geoffrey R. Weiss, Jeffrey K. Giguere, Karen Kelly, John Crowley and David R. Gandara
      Clin Cancer Res August 1 2004 10 (15) 5022-5026; DOI:10.1158/1078-0432.CCR-04-0002

    • Regular Articles
      A Phase I Study of Interleukin 12 with Trastuzumab in Patients with Human Epidermal Growth Factor Receptor-2-Overexpressing Malignancies
      Robin Parihar, Padma Nadella, Adrian Lewis, Rhonda Jensen, Carrie De Hoff, Julie E. Dierksheide, Anne M. VanBuskirk, Cynthia M. Magro, Donn C. Young, Charles L. Shapiro and William E. Carson III
      Clin Cancer Res August 1 2004 10 (15) 5027-5037; DOI:10.1158/1078-0432.CCR-04-0265

    • Regular Articles
      Phase I Trial of the Cyclin-Dependent Kinase Inhibitor Flavopiridol in Combination with Docetaxel in Patients with Metastatic Breast Cancer
      Antoinette R. Tan, Xiaowei Yang, Arlene Berman, Suoping Zhai, Alex Sparreboom, Allyson L. Parr, Catherine Chow, Jaime S. Brahim, Seth M. Steinberg, William D. Figg and Sandra M. Swain
      Clin Cancer Res August 1 2004 10 (15) 5038-5047; DOI:10.1158/1078-0432.CCR-04-0025

    • Regular Articles
      A Phase I Pharmacokinetic and Biological Correlative Study of Oblimersen Sodium (Genasense, G3139), an Antisense Oligonucleotide to the Bcl-2 mRNA, and of Docetaxel in Patients with Hormone-Refractory Prostate Cancer
      Anthony W. Tolcher, John Kuhn, Garry Schwartz, Amita Patnaik, Lisa A. Hammond, Ian Thompson, Howard Fingert, David Bushnell, Shazli Malik, Jeffrey Kreisberg, Elzbieta Izbicka, Leslie Smetzer and Eric K. Rowinsky
      Clin Cancer Res August 1 2004 10 (15) 5048-5057; DOI:10.1158/1078-0432.CCR-03-0701

    • Regular Articles
      Phase I and Pharmacologic Study of Intermittently Administered 9-Nitrocamptothecin in Patients with Advanced Solid Tumors
      William C. Zamboni, Laura L. Jung, Merrill J. Egorin, Douglas M. Potter, David M. Friedland, Chandra P. Belani, Sanjiv S. Agarwala, Michael M. W. Wong, Marwan Fakih, Donald L. Trump, Ruzhi Jin, Sandra Strychor, Michael Vozniak, Monica Troetschel and Ramesh K. Ramanathan
      Clin Cancer Res August 1 2004 10 (15) 5058-5064; DOI:10.1158/1078-0432.CCR-03-0288

    • Regular Articles
      Extended Follow-up of Patients Treated with Imatinib Mesylate (Gleevec) for Chronic Myelogenous Leukemia Relapse after Allogeneic Transplantation
      Daniel J. DeAngelo, Ephraim P. Hochberg, Edwin P. Alyea, Janina Longtine, Stephanie Lee, Ilene Galinsky, Ben Parekkedon, Jerome Ritz, Joseph H. Antin, Richard M. Stone and Robert J. Soiffer
      Clin Cancer Res August 1 2004 10 (15) 5065-5071; DOI:10.1158/1078-0432.CCR-03-0580

    • Regular Articles
      Pharmacokinetics of O6-benzylguanine in Pediatric Patients with Central Nervous System Tumors
      Kathleen Neville, Susan Blaney, Mark Bernstein, Patrick Thompson, Denise Adams, Alexander Aleksic and Stacey Berg
      Clin Cancer Res August 1 2004 10 (15) 5072-5075; DOI:10.1158/1078-0432.CCR-03-0123

  • Molecular Oncology, Markers, Clinical Correlates

    • Regular Articles
      Prognostic Analysis of Early Lymphocyte Recovery in Patients with Advanced Breast Cancer Receiving High-Dose Chemotherapy with an Autologous Hematopoietic Progenitor Cell Transplant
      Yago Nieto, Elizabeth J. Shpall, Ian K. McNiece, Samia Nawaz, Julie Beaudet, Steve Rosinski, Julie Pellom, Victoria Slat-Vasquez, Peter A. McSweeney, Scott I. Bearman, James Murphy and Roy B. Jones
      Clin Cancer Res August 1 2004 10 (15) 5076-5086; DOI:10.1158/1078-0432.CCR-04-0117

    • Regular Articles
      Methylation of p16 CpG Islands Associated with Malignant Transformation of Gastric Dysplasia in a Population-Based Study
      Yu Sun, Dajun Deng, Wei-Cheng You, Hua Bai, Lian Zhang, Jing Zhou, Lin Shen, Jun-Ling Ma, Yu-Quan Xie and Ji-You Li
      Clin Cancer Res August 1 2004 10 (15) 5087-5093; DOI:10.1158/1078-0432.CCR-03-0622

    • Regular Articles
      B7-H1 Expression on Non-Small Cell Lung Cancer Cells and Its Relationship with Tumor-Infiltrating Lymphocytes and Their PD-1 Expression
      Jun Konishi, Koichi Yamazaki, Miyuki Azuma, Ichiro Kinoshita, Hirotoshi Dosaka-Akita and Masaharu Nishimura
      Clin Cancer Res August 1 2004 10 (15) 5094-5100; DOI:10.1158/1078-0432.CCR-04-0428

    • Regular Articles
      Expression of Pro- and Antiapoptotic Proteins in Circulating CD8+ T Cells of Patients with Squamous Cell Carcinoma of the Head and Neck
      Jeong-Whun Kim, Takashi Tsukishiro, Jonas T. Johnson and Theresa L. Whiteside
      Clin Cancer Res August 1 2004 10 (15) 5101-5110; DOI:10.1158/1078-0432.CCR-04-0309

    • Regular Articles
      Primary Acute Lymphoblastic Leukemia Cells Use a Novel Promoter and 5′Noncoding Exon for the Human Reduced Folate Carrier That Encodes a Modified Carrier Translated from an Upstream Translational Start
      Robin M. Flatley, Scott G. Payton, Jeffrey W. Taub and Larry H. Matherly
      Clin Cancer Res August 1 2004 10 (15) 5111-5122; DOI:10.1158/1078-0432.CCR-04-0116

    • Regular Articles
      Elevated S-Phase Kinase-Associated Protein 2 Protein Expression in Acute Myelogenous Leukemia
      Yoo Hong Min, June-Won Cheong, Mark Hong Lee, Ji Yeon Kim, Seung Tae Lee, Jee Sook Hahn and Yun Woong Ko
      Clin Cancer Res August 1 2004 10 (15) 5123-5130; DOI:10.1158/1078-0432.CCR-04-0136

    • Regular Articles
      Promoter Hypermethylation of Resected Bronchial Margins
      Mingzhou Guo, Michael G. House, Craig Hooker, Yu Han, Elizabeth Heath, Edward Gabrielson, Stephen C. Yang, Stephen B. Baylin, James G. Herman and Malcolm V. Brock
      Clin Cancer Res August 1 2004 10 (15) 5131-5136; DOI:10.1158/1078-0432.CCR-03-0763

    • Regular Articles
      Expression of Vascular Endothelial Growth Factor Receptor-3 by Lymphatic Endothelial Cells Is Associated with Lymph Node Metastasis in Prostate Cancer
      Yiping Zeng, Kenneth Opeskin, Megan E. Baldwin, Lisa G. Horvath, Marc G. Achen, Steven A. Stacker, Robert L. Sutherland and Elizabeth D. Williams
      Clin Cancer Res August 1 2004 10 (15) 5137-5144; DOI:10.1158/1078-0432.CCR-03-0434

    • Regular Articles
      EphA2 Expression Is Associated with Aggressive Features in Ovarian Carcinoma
      Premal H. Thaker, Michael Deavers, Joseph Celestino, Angela Thornton, Mavis S. Fletcher, Charles N. Landen, Michael S. Kinch, Peter A. Kiener and Anil K. Sood
      Clin Cancer Res August 1 2004 10 (15) 5145-5150; DOI:10.1158/1078-0432.CCR-03-0589

    • Regular Articles
      Relevance of Different UGT1A1 Polymorphisms in Irinotecan-Induced Toxicity
      Elisabeth Rouits, Michèle Boisdron-Celle, Agnès Dumont, Olivier Guérin, Alain Morel and Erick Gamelin
      Clin Cancer Res August 1 2004 10 (15) 5151-5159; DOI:10.1158/1078-0432.CCR-03-0548

    • Regular Articles
      Patterns of Chromosomal Alterations in Breast Ductal Carcinoma In situ
      E. Shelley Hwang, Sandy DeVries, Karen L. Chew, Dan H. Moore II, Karla Kerlikowske, Ann Thor, Britt-Marie Ljung and Frederic M. Waldman
      Clin Cancer Res August 1 2004 10 (15) 5160-5167; DOI:10.1158/1078-0432.CCR-04-0165

    • Regular Articles
      Cyclin D1, p53, and p21Waf1/Cip1 Expression Is Predictive of Poor Clinical Outcome in Serous Epithelial Ovarian Cancer
      Anish Bali, Philippa M. O’Brien, Lyndal S. Edwards, Robert L. Sutherland, Neville F. Hacker and Susan M. Henshall
      Clin Cancer Res August 1 2004 10 (15) 5168-5177; DOI:10.1158/1078-0432.CCR-03-0751

    • Regular Articles
      Distribution and Clinical Significance of Heparan Sulfate Proteoglycans in Ovarian Cancer
      E. June Davies, Fiona H. Blackhall, Jonathan H. Shanks, Guido David, Alan T. McGown, Ric Swindell, Richard J. Slade, Pierre Martin-Hirsch, John T. Gallagher and Gordon C. Jayson
      Clin Cancer Res August 1 2004 10 (15) 5178-5186; DOI:10.1158/1078-0432.CCR-03-0103

  • Experimental Therapeutics, Preclinical Pharmacology

    • Regular Articles
      Noscapine Crosses the Blood-Brain Barrier and Inhibits Glioblastoma Growth
      Jaren W. Landen, Vincent Hau, Mingshen Wang, Thomas Davis, Brian Ciliax, Bruce H. Wainer, Erwin G. Van Meir, Johnathan D. Glass, Harish C. Joshi and David R. Archer
      Clin Cancer Res August 1 2004 10 (15) 5187-5201; DOI:10.1158/1078-0432.CCR-04-0360

    • Regular Articles
      CD95-Mediated Apoptosis Is Impaired at Receptor Level by Cellular FLICE-Inhibitory Protein (Long Form) in Wild-Type p53 Human Ovarian Carcinoma
      Delia Mezzanzanica, Emanuela Balladore, Fabio Turatti, Elena Luison, Paola Alberti, Marina Bagnoli, Mariangela Figini, Alessandra Mazzoni, Francesco Raspagliesi, Maria Oggionni, Silvana Pilotti and Silvana Canevari
      Clin Cancer Res August 1 2004 10 (15) 5202-5214; DOI:10.1158/1078-0432.CCR-03-0537

    • Regular Articles
      Mifepristone Induces Growth Arrest, Caspase Activation, and Apoptosis of Estrogen Receptor-Expressing, Antiestrogen-Resistant Breast Cancer Cells
      Virgil T. Gaddy, John T. Barrett, Jennifer N. Delk, Andre M. Kallab, Alan G. Porter and Patricia V. Schoenlein
      Clin Cancer Res August 1 2004 10 (15) 5215-5225; DOI:10.1158/1078-0432.CCR-03-0637

    • Regular Articles
      The Effect of Megestrol Acetate on Growth of HepG2 Cells In vitro and In vivo
      Kai Zhang and Pierce K. H. Chow
      Clin Cancer Res August 1 2004 10 (15) 5226-5232; DOI:10.1158/1078-0432.CCR-04-0061

    • Regular Articles
      Pharmacokinetics and Tissue Disposition of Indole-3-carbinol and Its Acid Condensation Products after Oral Administration to Mice
      Mark J. Anderton, Margaret M. Manson, Richard D. Verschoyle, Andreas Gescher, John H. Lamb, Peter B. Farmer, William P. Steward and Marion L. Williams
      Clin Cancer Res August 1 2004 10 (15) 5233-5241; DOI:10.1158/1078-0432.CCR-04-0163

    • Regular Articles
      In vitro Combination Treatment with Perifosine and UCN-01 Demonstrates Synergism against Prostate (PC-3) and Lung (A549) Epithelial Adenocarcinoma Cell Lines
      Girija P. Dasmahapatra, Parijat Didolkar, Michael C. Alley, Somiranjan Ghosh, Edward A. Sausville and Krishnendu K. Roy
      Clin Cancer Res August 1 2004 10 (15) 5242-5252; DOI:10.1158/1078-0432.CCR-03-0534

    • Regular Articles
      trans-3,4,5′-Trihydroxystibene Inhibits Hypoxia-Inducible Factor 1α and Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells
      Zongxian Cao, Jing Fang, Chang Xia, Xianglin Shi and Bing-Hua Jiang
      Clin Cancer Res August 1 2004 10 (15) 5253-5263; DOI:10.1158/1078-0432.CCR-03-0588

    • Regular Articles
      Nitric Oxide Accelerates Interleukin-13 Cytotoxin-Mediated Regression in Head and Neck Cancer Animal Model
      Koji Kawakami, Mariko Kawakami and Raj K. Puri
      Clin Cancer Res August 1 2004 10 (15) 5264-5270; DOI:10.1158/1078-0432.CCR-04-0314

    • Regular Articles
      Class I Histone Deacetylase-Selective Novel Synthetic Inhibitors Potently Inhibit Human Tumor Proliferation
      Jung-Hyun Park, Yeonjoo Jung, Tai Young Kim, Sang Gyun Kim, Hyun-Soon Jong, Jung Weon Lee, Dae-Kee Kim, Jong-Soo Lee, Noe Kyeong Kim, Tae-You Kim and Yung-Jue Bang
      Clin Cancer Res August 1 2004 10 (15) 5271-5281; DOI:10.1158/1078-0432.CCR-03-0709

    • Regular Articles
      A Concentrated Aglycone Isoflavone Preparation (GCP) That Demonstrates Potent Anti-Prostate Cancer Activity In vitro and In vivo
      Debra L. Bemis, Jillian L. Capodice, Manisha Desai, Ralph Buttyan and Aaron E. Katz
      Clin Cancer Res August 1 2004 10 (15) 5282-5292; DOI:10.1158/1078-0432.CCR-03-0828

Letter to the Editor

  • Letter to the Editor
    Identification of Serum Amyloid A Protein As a Potentially Useful Biomarker for Nasopharyngeal Carcinoma
    Eleftherios P. Diamandis
    Clin Cancer Res August 1 2004 10 (15) 5293-5294; DOI:10.1158/1078-0432.CCR-04-0377

Correction

  • Correction
    Correction: Article on Analysis of p53 Alterations in Lung Biopsies
    Clin Cancer Res August 1 2004 10 (15) 5295-5295; DOI:10.1158/1078-0432.CCR-10-15-CORA

  • Correction
    Correction: Article on Predicting Early Failure in Node-Positive Breast Cancer
    Clin Cancer Res August 1 2004 10 (15) 5295-5295; DOI:10.1158/1078-0432.CCR-10-15-CORB

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Clinical Cancer Research: 10 (15)
August 2004
Volume 10, Issue 15
  • Table of Contents
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Issue Highlights

  • Antitumor Activity of Systemically Delivered Ribozymes Targeting Murine Telomerase RNA
  • Phase I and Pharmacokinetic Study of the Oral Fluoropyrimidine S-1 on a Once-Daily-for-28-Day Schedule in Patients with Advanced Malignancies
  • Phase I Study of Concomitant Chemoradiotherapy with Paclitaxel, Fluorouracil, Gemcitabine, and Twice-Daily Radiation in Patients with Poor-Prognosis Cancer of the Head and Neck
  • CpG Island Hypermethylation of the DNA Repair Enzyme Methyltransferase Predicts Response to Temozolomide in Primary Gliomas

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  • Perspective
  • Review
  • Featured Articles
    • Clinical Trials
    • Molecular Oncology, Markers, Clinical Correlates
    • Experimental Therapeutics, Preclinical Pharmacology
  • Regular Articles
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    • Molecular Oncology, Markers, Clinical Correlates
    • Experimental Therapeutics, Preclinical Pharmacology
  • Letter to the Editor
  • Correction
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  • Characterization of Glioblastoma Patient-Derived Xenografts
  • FLASH-RT Spares Lung Progenitor Cells
  • AR Gene Rearrangements in Prostate Cancer
  • PDAC and GATA6 Expression
  • Guadecitabine and Carboplatin in Ovarian Cancer
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Clinical Cancer Research
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