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Clinical Cancer Research
Clinical Cancer Research
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About the Cover

Cover image

Cover image expansion

The cover figure shows a model of the V559D mutant of c-KIT found in some gastrointestinal stromal tumors (GIST). This mutation (shown in light pink, just above the tyrosine ring in the lower middle of the figure) is in a hydrophobic pocket between the two lobes. The mutation is likely to disrupt the binding of the inhibitory segment, leading to kinase activation. Other residues in this segment that are frequently mutated in GIST patients are shown in yellow. A portion of the inhibitory segment in front of the tyrosine has been omitted from the figure to reveal the mutated position. For further details, see Tarn et al. on page 3668 in this issue.

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Clinical Cancer Research: 11 (10)
May 2005
Volume 11, Issue 10
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Issue Highlights

  • Analysis of KIT Mutations in Sporadic and Familial Gastrointestinal Stromal Tumors: Therapeutic Implications through Protein Modeling
  • DDEF1 Is Located in an Amplified Region of Chromosome 8q and Is Overexpressed in Uveal Melanoma
  • A Rare Transporter Associated with Antigen Processing Polymorphism Overpresented in HLAlow Colon Cancer Reveals the Functional Significance of the Signature Domain in Antigen Processing
  • Circulating Tumor Cells in Breast Cancer: Correlation to Bone Marrow Micrometastases, Heterogeneous Response to Systemic Therapy and Low Proliferative Activity
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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