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Table of Contents

Editorials

  • Editorials
    Phase II Oncology Trials: Let's Be Positive
    Mark J. Ratain
    Clin Cancer Res August 15 2005 11 (16) 5661-5662; DOI:10.1158/1078-0432.CCR-05-1046

  • Editorials
    Personalized, Multivalent, and More Affordable: The Globalization of Vaccines
    Waldemar Debinski
    Clin Cancer Res August 15 2005 11 (16) 5663-5664; DOI:10.1158/1078-0432.CCR-05-1101

The Biology Behind

  • The Biology Behind
    Cyclin D1 and Pancreatic Carcinoma: A Proliferative Agonist and Chemotherapeutic Antagonist
    J. Alan Diehl and Sharon Benzeno
    Clin Cancer Res August 15 2005 11 (16) 5665-5667; DOI:10.1158/1078-0432.CCR-05-1016

  • The Biology Behind
    Epidermal Growth Factor Receptor Mutations in Non–Small Cell Lung Cancer: Predicting Clinical Response to Kinase Inhibitors
    Lecia V. Sequist, Daniel A. Haber and Thomas J. Lynch
    Clin Cancer Res August 15 2005 11 (16) 5668-5670; DOI:10.1158/1078-0432.CCR-05-1055

Report from the FDA

  • Report from the FDA
    Letrozole in the Extended Adjuvant Treatment of Postmenopausal Women with History of Early-Stage Breast Cancer Who Have Completed 5 Years of Adjuvant Tamoxifen
    Bhupinder S. Mann, John R. Johnson, Roswitha Kelly, Rajeshwari Sridhara, Grant Williams and Richard Pazdur
    Clin Cancer Res August 15 2005 11 (16) 5671-5677; DOI:10.1158/1078-0432.CCR-05-0354

Human Cancer Biology

  • Human Cancer Biology
    Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy
    Roman Rouzier, Charles M. Perou, W. Fraser Symmans, Nuhad Ibrahim, Massimo Cristofanilli, Keith Anderson, Kenneth R. Hess, James Stec, Mark Ayers, Peter Wagner, Paolo Morandi, Chang Fan, Islam Rabiul, Jeffrey S. Ross, Gabriel N. Hortobagyi and Lajos Pusztai
    Clin Cancer Res August 15 2005 11 (16) 5678-5685; DOI:10.1158/1078-0432.CCR-04-2421

  • Human Cancer Biology
    CCR7 and CXCR4 as Novel Biomarkers Predicting Axillary Lymph Node Metastasis in T1 Breast Cancer
    Neslihan Cabioglu, M. Sertac Yazici, Banu Arun, Kristine R. Broglio, Gabriel N. Hortobagyi, Janet E. Price and Aysegul Sahin
    Clin Cancer Res August 15 2005 11 (16) 5686-5693; DOI:10.1158/1078-0432.CCR-05-0014

  • Human Cancer Biology
    Tissue Distribution of Human Papillomavirus 16 DNA Integration in Patients with Tonsillar Carcinoma
    Shahnaz Begum, Dengfeng Cao, Maura Gillison, Marianna Zahurak and William H. Westra
    Clin Cancer Res August 15 2005 11 (16) 5694-5699; DOI:10.1158/1078-0432.CCR-05-0587

  • Human Cancer Biology
    A Comparison Study of Different PCR Assays in Measuring Circulating Plasma Epstein-Barr Virus DNA Levels in Patients with Nasopharyngeal Carcinoma
    Quynh-Thu Le, Carol D. Jones, Tsz-Kok Yau, Haider A. Shirazi, Priscilla H. Wong, Ella N. Thomas, Bruce K. Patterson, Anne W.M. Lee and James L. Zehnder
    Clin Cancer Res August 15 2005 11 (16) 5700-5707; DOI:10.1158/1078-0432.CCR-05-0648

  • Human Cancer Biology
    Expression of Functional B7-H2 and B7.2 Costimulatory Molecules and Their Prognostic Implications in De novo Acute Myeloid Leukemia
    Hideto Tamura, Kazuo Dan, Koji Tamada, Kyoko Nakamura, Yumiko Shioi, Hideya Hyodo, Sheng-Dian Wang, Haidong Dong, Lieping Chen and Kiyoyuki Ogata
    Clin Cancer Res August 15 2005 11 (16) 5708-5717; DOI:10.1158/1078-0432.CCR-04-2672

  • Human Cancer Biology
    Interleukin-1 and Interleukin-6 Gene Polymorphisms and the Risk of Breast Cancer in Caucasian Women
    Lukas A. Hefler, Christoph Grimm, Tilmann Lantzsch, Dieter Lampe, Sepp Leodolter, Heinz Koelbl, Georg Heinze, Alexander Reinthaller, Dan Tong-Cacsire, Clemens Tempfer and Robert Zeillinger
    Clin Cancer Res August 15 2005 11 (16) 5718-5721; DOI:10.1158/1078-0432.CCR-05-0001

  • Human Cancer Biology
    Identification of Two Molecular Groups of Seminomas by Using Expression and Tissue Microarrays
    Matthias D. Hofer, Tara J. Browne, Le He, Rolf I. Skotheim, Ragnhild A. Lothe and Mark A. Rubin
    Clin Cancer Res August 15 2005 11 (16) 5722-5729; DOI:10.1158/1078-0432.CCR-05-0533

  • Human Cancer Biology
    Gene Signatures of Progression and Metastasis in Renal Cell Cancer
    Jon Jones, Hasan Otu, Dimitrios Spentzos, Shakirahmed Kolia, Mehmet Inan, Wolf D. Beecken, Christian Fellbaum, Xuesong Gu, Marie Joseph, Allan J. Pantuck, Dietger Jonas and Towia A. Libermann
    Clin Cancer Res August 15 2005 11 (16) 5730-5739; DOI:10.1158/1078-0432.CCR-04-2225

  • Human Cancer Biology
    Comprehensive Analysis of CDKN2A Status in Microdissected Urothelial Cell Carcinoma Reveals Potential Haploinsufficiency, a High Frequency of Homozygous Co-deletion and Associations with Clinical Phenotype
    Emma J. Chapman, Patricia Harnden, Philip Chambers, Colin Johnston and Margaret A. Knowles
    Clin Cancer Res August 15 2005 11 (16) 5740-5747; DOI:10.1158/1078-0432.CCR-05-0411

  • Human Cancer Biology
    Decreased T-Cell Receptor Excision Circles in Cutaneous T-Cell Lymphoma
    Kei-ichi Yamanaka, Nikhil Yawalkar, David A. Jones, Daniel Hurwitz, Katalin Ferenczi, Sara Eapen and Thomas S. Kupper
    Clin Cancer Res August 15 2005 11 (16) 5748-5755; DOI:10.1158/1078-0432.CCR-04-2514

  • Human Cancer Biology
    The Fragile Histidine Triad Gene: A Molecular Link Between Cigarette Smoking and Cervical Cancer
    Christine H. Holschneider, Rae Lynn Baldwin, Kiran Tumber, Chisa Aoyama and Beth Y. Karlan
    Clin Cancer Res August 15 2005 11 (16) 5756-5763; DOI:10.1158/1078-0432.CCR-05-0234

  • Human Cancer Biology
    The IgLON Family in Epithelial Ovarian Cancer: Expression Profiles and Clinicopathologic Correlates
    Evangelos Ntougkos, Robert Rush, Diane Scott, Tobias Frankenberg, Hani Gabra, John F. Smyth and Grant C. Sellar
    Clin Cancer Res August 15 2005 11 (16) 5764-5768; DOI:10.1158/1078-0432.CCR-04-2388

  • Human Cancer Biology
    WOX1 Is Essential for UVB Irradiation–Induced Apoptosis and Down-Regulated via Translational Blockade in UVB-Induced Cutaneous Squamous Cell Carcinoma In vivo
    Feng-Jie Lai, Ching-Li Cheng, Shur-Tzu Chen, Chin-Han Wu, Li-Jin Hsu, J. Yu-Yun Lee, Sheau-Chiou Chao, Maw-Chang Sheen, Ching-Liang Shen, Nan-Shan Chang and Hamm-Ming Sheu
    Clin Cancer Res August 15 2005 11 (16) 5769-5777; DOI:10.1158/1078-0432.CCR-04-2274

  • Human Cancer Biology
    Expression of Autocrine Motility Factor Correlates with the Angiogenic Phenotype of and Poor Prognosis for Human Gastric Cancer
    Weida Gong, Yixing Jiang, Liwei Wang, Daoyan Wei, James Yao, Suyun Huang, Shengyun Fang and Keping Xie
    Clin Cancer Res August 15 2005 11 (16) 5778-5783; DOI:10.1158/1078-0432.CCR-05-0214

  • Human Cancer Biology
    Phosphorylation of the 6-Phosphofructo-2-Kinase/Fructose 2,6-Bisphosphatase/PFKFB3 Family of Glycolytic Regulators in Human Cancer
    Hidenori Bando, Toshiya Atsumi, Taro Nishio, Hirokatsu Niwa, Shinya Mishima, Chikara Shimizu, Narihito Yoshioka, Richard Bucala and Takao Koike
    Clin Cancer Res August 15 2005 11 (16) 5784-5792; DOI:10.1158/1078-0432.CCR-05-0149

  • Human Cancer Biology
    Cytochrome P450 1B1 Is Overexpressed and Regulated by Hypomethylation in Prostate Cancer
    Takashi Tokizane, Hiroaki Shiina, Mikio Igawa, Hideki Enokida, Shinji Urakami, Toshifumi Kawakami, Tatsuya Ogishima, Steven T. Okino, Long-Cheng Li, Yuichiro Tanaka, Norio Nonomura, Akihiko Okuyama and Rajvir Dahiya
    Clin Cancer Res August 15 2005 11 (16) 5793-5801; DOI:10.1158/1078-0432.CCR-04-2545

  • Human Cancer Biology
    Role of Mononuclear Cells and Inflammatory Cytokines in Pancreatic Cancer-Related Cachexia
    Marc E. Martignoni, Phillipp Kunze, Wulf Hildebrandt, Beat Künzli, Pascal Berberat, Thomas Giese, Oliver Klöters, Jürgen Hammer, Markus W. Büchler, Nathalia A. Giese and Helmut Friess
    Clin Cancer Res August 15 2005 11 (16) 5802-5808; DOI:10.1158/1078-0432.CCR-05-0185

  • Human Cancer Biology
    Cyr61 Induces Gastric Cancer Cell Motility/Invasion via Activation of the Integrin/Nuclear Factor-κB/Cyclooxygenase-2 Signaling Pathway
    Ming-Tsai Lin, Chung-Yaou Zuon, Cheng-Chi Chang, Szu-Ta Chen, Chih-Ping Chen, Been-Ren Lin, Ming-Yang Wang, Yung-Ming Jeng, King-Jen Chang, Po-Huang Lee, Wei-Jao Chen and Min-Liang Kuo
    Clin Cancer Res August 15 2005 11 (16) 5809-5820; DOI:10.1158/1078-0432.CCR-04-2639

  • Human Cancer Biology
    Alteration of Gene Expression in Human Hepatocellular Carcinoma with Integrated Hepatitis B Virus DNA
    Akihiro Tamori, Yoshihiro Yamanishi, Shuichi Kawashima, Minoru Kanehisa, Masaru Enomoto, Hiromu Tanaka, Shoji Kubo, Susumu Shiomi and Shuhei Nishiguchi
    Clin Cancer Res August 15 2005 11 (16) 5821-5826; DOI:10.1158/1078-0432.CCR-04-2055

Imaging, Diagnosis, Prognosis

  • Imaging, Diagnosis, Prognosis
    Early Antiangiogenic Activity of SU11248 Evaluated In vivo by Dynamic Contrast-Enhanced Magnetic Resonance Imaging in an Experimental Model of Colon Carcinoma
    Pasquina Marzola, Anna Degrassi, Laura Calderan, Paolo Farace, Elena Nicolato, Caterina Crescimanno, Marco Sandri, Anna Giusti, Enrico Pesenti, Andrea Terron, Andrea Sbarbati and Francesco Osculati
    Clin Cancer Res August 15 2005 11 (16) 5827-5832; DOI:10.1158/1078-0432.CCR-04-2655

  • Imaging, Diagnosis, Prognosis
    Characterization of a New Antibody Raised against the NH2 Terminus of P-Glycoprotein
    Prema S. Rao, Rajgopal Govindarajan, Kavita B. Mallya, William West and U. Subrahmanyeswara Rao
    Clin Cancer Res August 15 2005 11 (16) 5833-5839; DOI:10.1158/1078-0432.CCR-04-2182

  • Imaging, Diagnosis, Prognosis
    New Monoclonal Antibodies to Mesothelin Useful for Immunohistochemistry, Fluorescence-Activated Cell Sorting, Western Blotting, and ELISA
    Masanori Onda, Mark Willingham, Satoshi Nagata, Tapan K. Bera, Richard Beers, Mitchell Ho, Raffit Hassan, Robert J. Kreitman and Ira Pastan
    Clin Cancer Res August 15 2005 11 (16) 5840-5846; DOI:10.1158/1078-0432.CCR-05-0578

  • Imaging, Diagnosis, Prognosis
    Proteomic Analysis of Apoptotic Pathways Reveals Prognostic Factors in Follicular Lymphoma
    Christian Gulmann, Virginia Espina, Emanuel Petricoin III, Dan L. Longo, Mariarita Santi, Turid Knutsen, Mark Raffeld, Elaine S. Jaffe, Lance A. Liotta and Andrew L. Feldman
    Clin Cancer Res August 15 2005 11 (16) 5847-5855; DOI:10.1158/1078-0432.CCR-05-0637

  • Imaging, Diagnosis, Prognosis
    Quantitative Determination of Nuclear and Cytoplasmic Epidermal Growth Factor Receptor Expression in Oropharyngeal Squamous Cell Cancer by Using Automated Quantitative Analysis
    Amanda Psyrri, Ziwei Yu, Paul M. Weinberger, Clarence Sasaki, Bruce Haffty, Robert Camp, David Rimm and Barbara Ann Burtness
    Clin Cancer Res August 15 2005 11 (16) 5856-5862; DOI:10.1158/1078-0432.CCR-05-0420

  • Imaging, Diagnosis, Prognosis
    Activation of Signal Transducer and Activator of Transcription-5 in Prostate Cancer Predicts Early Recurrence
    Hongzhen Li, Ying Zhang, Andrew Glass, Tobias Zellweger, Edmund Gehan, Lukas Bubendorf, Edward P. Gelmann and Marja T. Nevalainen
    Clin Cancer Res August 15 2005 11 (16) 5863-5868; DOI:10.1158/1078-0432.CCR-05-0562

  • Imaging, Diagnosis, Prognosis
    P-Cadherin Overexpression Is an Indicator of Clinical Outcome in Invasive Breast Carcinomas and Is Associated with CDH3 Promoter Hypomethylation
    Joana Paredes, André Albergaria, João T. Oliveira, Carmen Jerónimo, Fernanda Milanezi and Fernando C. Schmitt
    Clin Cancer Res August 15 2005 11 (16) 5869-5877; DOI:10.1158/1078-0432.CCR-05-0059

  • Imaging, Diagnosis, Prognosis
    Activating Mutations in the Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor Are Associated with Improved Survival in Gefitinib-Treated Chemorefractory Lung Adenocarcinomas
    Miguel Taron, Yukito Ichinose, Rafael Rosell, Tony Mok, Bartomeu Massuti, Lurdes Zamora, Jose Luis Mate, Christian Manegold, Mayumi Ono, Cristina Queralt, Thierry Jahan, Jose Javier Sanchez, Maria Sanchez-Ronco, Victor Hsue, David Jablons, Jose Miguel Sanchez and Teresa Moran
    Clin Cancer Res August 15 2005 11 (16) 5878-5885; DOI:10.1158/1078-0432.CCR-04-2618

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Analysis of the DPYD Gene Implicated in 5-Fluorouracil Catabolism in a Cohort of Caucasian Individuals
    Katharina Seck, Silvia Riemer, Ronald Kates, Tobias Ullrich, Verena Lutz, Nadia Harbeck, Manfred Schmitt, Marion Kiechle, Robert Diasio and Eva Gross
    Clin Cancer Res August 15 2005 11 (16) 5886-5892; DOI:10.1158/1078-0432.CCR-04-1784

  • Cancer Therapy: Clinical
    Pharmacokinetics of Dactinomycin in a Pediatric Patient Population: a United Kingdom Children's Cancer Study Group Study
    Gareth J. Veal, Michael Cole, Julie Errington, Annie Parry, Juliet Hale, Andrew D.J. Pearson, Karen Howe, Julia C. Chisholm, Carol Beane, Bernadette Brennan, Fiona Waters, Adam Glaser, Sue Hemsworth, Heather McDowell, Yvonne Wright, Kathy Pritchard-Jones, Ross Pinkerton, Gail Jenner, James Nicholson, Ann M. Elsworth, Alan V. Boddy and UKCCSG Pharmacology Working Group
    Clin Cancer Res August 15 2005 11 (16) 5893-5899; DOI:10.1158/1078-0432.CCR-04-2546

  • Cancer Therapy: Clinical
    Immunologic Evaluation of Personalized Peptide Vaccination for Patients with Advanced Malignant Glioma
    Naoki Yajima, Ryuya Yamanaka, Takashi Mine, Naoto Tsuchiya, Jumpei Homma, Masakazu Sano, Terukazu Kuramoto, Yayoi Obata, Nobukazu Komatsu, Yoshimi Arima, Akira Yamada, Minoru Shigemori, Kyogo Itoh and Ryuichi Tanaka
    Clin Cancer Res August 15 2005 11 (16) 5900-5911; DOI:10.1158/1078-0432.CCR-05-0559

  • Cancer Therapy: Clinical
    Phase I Study of Combined Pegylated Liposomal Doxorubicin with Protracted Daily Topotecan for Ovarian Cancer
    Deepu Mirchandani, Howard Hochster, Anne Hamilton, Leonard Liebes, Herman Yee, John P. Curtin, Sang Lee, Joan Sorich, Cornelia Dellenbaugh and Franco M. Muggia
    Clin Cancer Res August 15 2005 11 (16) 5912-5919; DOI:10.1158/1078-0432.CCR-04-1240

  • Cancer Therapy: Clinical
    High-Dose Radioimmunotherapy Combined with Fixed, Low-Dose Paclitaxel in Metastatic Prostate and Breast Cancer by Using a MUC-1 Monoclonal Antibody, m170, Linked to Indium-111/Yttrium-90 via a Cathepsin Cleavable Linker with Cyclosporine to Prevent Human Anti-mouse Antibody
    Carol M. Richman, Sally J. DeNardo, Robert T. O'Donnell, Aina Yuan, Sui Shen, Desiree S. Goldstein, Joseph M. Tuscano, Ted Wun, Helen K. Chew, Primo N. Lara, David L. Kukis, Arutselvan Natarajan, Claude F. Meares, Kathleen R. Lamborn and Gerald L. DeNardo
    Clin Cancer Res August 15 2005 11 (16) 5920-5927; DOI:10.1158/1078-0432.CCR-05-0211

  • Cancer Therapy: Clinical
    Objective Responses in Patients with Malignant Melanoma or Renal Cell Cancer in Early Clinical Studies Do Not Predict Regulatory Approval
    John Goffin, Stefan Baral, Dongsheng Tu, Dora Nomikos and Lesley Seymour
    Clin Cancer Res August 15 2005 11 (16) 5928-5934; DOI:10.1158/1078-0432.CCR-05-0130

  • Cancer Therapy: Clinical
    Phase 1 Trial of Flavopiridol Combined with Cisplatin or Carboplatin in Patients with Advanced Malignancies with the Assessment of Pharmacokinetic and Pharmacodynamic End Points
    Keith C. Bible, Janet L. Lensing, Sacha A. Nelson, Yean K. Lee, Joel M. Reid, Matthew M. Ames, Crescent R. Isham, Jill Piens, Stacie L. Rubin, Joseph Rubin, Scott H. Kaufmann, Pamela J. Atherton, Jeffrey A. Sloan, Michelle K. Daiss, Alex A. Adjei and Charles Erlichman
    Clin Cancer Res August 15 2005 11 (16) 5935-5941; DOI:10.1158/1078-0432.CCR-04-2566

  • Cancer Therapy: Clinical
    Phase I and Pharmacokinetic Study of Weekly Docetaxel, Cisplatin, and Daily Capecitabine in Patients with Advanced Solid Tumors
    Marwan G. Fakih, Patrick J. Creaven, Nithya Ramnath, Donald Trump, Milind Javle, Sandra Strychor, Trisha V.W. Repinski, Beth A. Zamboni, James K. Schwarz, Renee A. French and William C. Zamboni
    Clin Cancer Res August 15 2005 11 (16) 5942-5949; DOI:10.1158/1078-0432.CCR-05-0116

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    CpG Immunomer DNA Enhances Antisense Protein Kinase A RIα Inhibition of Multidrug-Resistant Colon Carcinoma Growth in Nude Mice: Molecular Basis for Combinatorial Therapy
    Maria V. Nesterova, Natalie R. Johnson, Trina Stewart, Scott Abrams and Yoon S. Cho-Chung
    Clin Cancer Res August 15 2005 11 (16) 5950-5955; DOI:10.1158/1078-0432.CCR-05-0624

  • Cancer Therapy: Preclinical
    Radiation and Transforming Growth Factor-β Cooperate in Transcriptional Activation of the Profibrotic Plasminogen Activator Inhibitor-1 Gene
    Jurre Hageman, Bart J. Eggen, Tom Rozema, Kevin Damman, Harm H. Kampinga and Robert P. Coppes
    Clin Cancer Res August 15 2005 11 (16) 5956-5964; DOI:10.1158/1078-0432.CCR-05-0427

  • Cancer Therapy: Preclinical
    PEX-Producing Human Neural Stem Cells Inhibit Tumor Growth in a Mouse Glioma Model
    Seung-Ki Kim, Theresa G. Cargioli, Marcelle Machluf, Wendy Yang, Yanping Sun, Ruqayyah Al-Hashem, Seung U. Kim, Peter M. Black and Rona S. Carroll
    Clin Cancer Res August 15 2005 11 (16) 5965-5970; DOI:10.1158/1078-0432.CCR-05-0371

  • Cancer Therapy: Preclinical
    Generation of Rituximab Polymer May Cause Hyper-Cross-linking–Induced Apoptosis in Non-Hodgkin's Lymphomas
    Nan Zhang, Leslie A. Khawli, Peisheng Hu and Alan L. Epstein
    Clin Cancer Res August 15 2005 11 (16) 5971-5980; DOI:10.1158/1078-0432.CCR-05-0554

  • Cancer Therapy: Preclinical
    Plasma and Cerebrospinal Fluid Pharmacokinetics of Clofarabine in Nonhuman Primates
    Stacey L. Berg, Peter L. Bonate, Jed G. Nuchtern, Robert Dauser, Leticia McGuffey, Bruce Bernacky and Susan M. Blaney
    Clin Cancer Res August 15 2005 11 (16) 5981-5983; DOI:10.1158/1078-0432.CCR-05-0261

  • Cancer Therapy: Preclinical
    Immunomodulatory Drug CC-5013 or CC-4047 and Rituximab Enhance Antitumor Activity in a Severe Combined Immunodeficient Mouse Lymphoma Model
    Francisco J. Hernandez-Ilizaliturri, Nishitha Reddy, Beata Holkova, Edris Ottman and Myron S. Czuczman
    Clin Cancer Res August 15 2005 11 (16) 5984-5992; DOI:10.1158/1078-0432.CCR-05-0577

  • Cancer Therapy: Preclinical
    Phase I/II Combined Chemoimmunotherapy with Carcinoembryonic Antigen–Derived HLA-A2–Restricted CAP-1 Peptide and Irinotecan, 5-Fluorouracil, and Leucovorin in Patients with Primary Metastatic Colorectal Cancer
    Martin R. Weihrauch, Sascha Ansén, Elke Jurkiewicz, Caroline Geisen, Zhinan Xia, Karen S. Anderson, Edith Gracien, Manuel Schmidt, Burghardt Wittig, Volker Diehl, Juergen Wolf, Heribert Bohlen and Lee M. Nadler
    Clin Cancer Res August 15 2005 11 (16) 5993-6001; DOI:10.1158/1078-0432.CCR-05-0018

  • Cancer Therapy: Preclinical
    Pseudolaric Acid B, a Novel Microtubule-Destabilizing Agent That Circumvents Multidrug Resistance Phenotype and Exhibits Antitumor Activity In vivo
    Vincent K.W. Wong, Pauline Chiu, Stephen S.M. Chung, Larry M.C. Chow, Yun-Zhe Zhao, Burton B. Yang and Ben C.B. Ko
    Clin Cancer Res August 15 2005 11 (16) 6002-6011; DOI:10.1158/1078-0432.CCR-05-0209

  • Cancer Therapy: Preclinical
    Targeting Matrilysin and Its Impact on Tumor Growth In vivo: The Potential Implications in Breast Cancer Therapy
    Wen G. Jiang, Gaynor Davies, Tracey A. Martin, Christian Parr, Gareth Watkins, Malcolm D. Mason, Kefah Mokbel and Robert E. Mansel
    Clin Cancer Res August 15 2005 11 (16) 6012-6019; DOI:10.1158/1078-0432.CCR-05-0275

  • Cancer Therapy: Preclinical
    Adeno-Associated Virus Vector-Mediated Systemic Delivery of IFN-β Combined with Low-Dose Cyclophosphamide Affects Tumor Regression in Murine Neuroblastoma Models
    Christian J. Streck, Paxton V. Dickson, Catherine Y.C. Ng, Junfang Zhou, John T. Gray, Amit C. Nathwani and Andrew M. Davidoff
    Clin Cancer Res August 15 2005 11 (16) 6020-6029; DOI:10.1158/1078-0432.CCR-05-0502

  • Cancer Therapy: Preclinical
    Indoleamine 2,3-Dioxygenase Serves as a Marker of Poor Prognosis in Gene Expression Profiles of Serous Ovarian Cancer Cells
    Aikou Okamoto, Takashi Nikaido, Kazunori Ochiai, Satoshi Takakura, Misato Saito, Yuko Aoki, Nobuya Ishii, Nozomu Yanaihara, Kyosuke Yamada, Osamu Takikawa, Rie Kawaguchi, Seiji Isonishi, Tadao Tanaka and Mitsuyoshi Urashima
    Clin Cancer Res August 15 2005 11 (16) 6030-6039; DOI:10.1158/1078-0432.CCR-04-2671

  • Cancer Therapy: Preclinical
    Green Tea Component, Catechin, Induces Apoptosis of Human Malignant B Cells via Production of Reactive Oxygen Species
    Tomonori Nakazato, Keisuke Ito, Yasuo Ikeda and Masahiro Kizaki
    Clin Cancer Res August 15 2005 11 (16) 6040-6049; DOI:10.1158/1078-0432.CCR-04-2273

  • Cancer Therapy: Preclinical
    Genetic Variations in the Glucocorticoid Receptor Gene Are Not Related to Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia
    Wim J.E. Tissing, Jules P.P. Meijerink, Monique L. den Boer, Bas Brinkhof, Elisabeth F.C. van Rossum, Elisabeth R. van Wering, Jan W. Koper, Pieter Sonneveld and Rob Pieters
    Clin Cancer Res August 15 2005 11 (16) 6050-6056; DOI:10.1158/1078-0432.CCR-04-2097

  • Cancer Therapy: Preclinical
    Characterization of a R115777-Resistant Human Multiple Myeloma Cell Line with Cross-Resistance to PS-341
    Robert Buzzeo, Steven Enkemann, Rama Nimmanapalli, Melissa Alsina, Mathias G. Lichtenheld, William S. Dalton and Darrin M. Beaupre
    Clin Cancer Res August 15 2005 11 (16) 6057-6064; DOI:10.1158/1078-0432.CCR-04-2685

  • Cancer Therapy: Preclinical
    Response of Non–Small Cell Lung Cancer Cells to the Inhibitors of Phosphatidylinositol 3-Kinase/Akt- and MAPK Kinase 4/c-Jun NH2-Terminal Kinase Pathways: An Effective Therapeutic Strategy for Lung Cancer
    Ho-Young Lee, Seung-Hyun Oh, Young-Ah Suh, Jin Hyen Baek, Vali Papadimitrakopoulou, Suyun Huang and Waun Ki Hong
    Clin Cancer Res August 15 2005 11 (16) 6065-6074; DOI:10.1158/1078-0432.CCR-05-0009

  • Cancer Therapy: Preclinical
    Overexpression of Cyclin D1 Promotes Tumor Cell Growth and Confers Resistance to Cisplatin-Mediated Apoptosis in an Elastase-myc Transgene–Expressing Pancreatic Tumor Cell Line
    Hector Biliran Jr., Yong Wang, Sanjeev Banerjee, Haiming Xu, Henry Heng, Archana Thakur, Aliccia Bollig, Fazlul H. Sarkar and Joshua D. Liao
    Clin Cancer Res August 15 2005 11 (16) 6075-6086; DOI:10.1158/1078-0432.CCR-04-2419

Cancer Prevention

  • Cancer Prevention
    Levels of Prostaglandin E Metabolite, the Major Urinary Metabolite of Prostaglandin E2, Are Increased in Smokers
    Neil D. Gross, Jay O. Boyle, Jason D. Morrow, Myles K. Williams, Chaya S. Moskowitz, Kotha Subbaramaiah, Andrew J. Dannenberg and Anna J. Duffield-Lillico
    Clin Cancer Res August 15 2005 11 (16) 6087-6093; DOI:10.1158/1078-0432.CCR-05-0733

Letters to the Editor

  • Letters to the Editor
    The Potential and Suitability of 2-Methoxyestradiol in Cancer Therapy
    Carolyn Sidor, Robert D'Amato and Kathy D. Miller
    Clin Cancer Res August 15 2005 11 (16) 6094-6096; DOI:10.1158/1078-0432.CCR-05-0724

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Clinical Cancer Research: 11 (16)
August 2005
Volume 11, Issue 16
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Issue Highlights

  • Overexpression of Cyclin D1 Promotes Tumor Cell Growth and Confers Resistance to Cisplatin-Mediated Apoptosis in an Elastase-myc Transgene–Expressing Pancreatic Tumor Cell Line
  • Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy
  • Tissue Distribution of Human Papillomavirus 16 DNA Integration in Patients with Tonsillar Carcinoma
  • Phase 1 Trial of Flavopiridol Combined with Cisplatin or Carboplatin in Patients with Advanced Malignancies with the Assessment of Pharmacokinetic and Pharmacodynamic End Points

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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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