Clinical Cancer Research: 11 (16)

Editorials

Editorials

Phase II Oncology Trials: Let's Be Positive

Mark J. Ratain

Clin Cancer Res August 15 2005 11 (16) 5661-5662; DOI:10.1158/1078-0432.CCR-05-1046
Editorials

Personalized, Multivalent, and More Affordable: The Globalization of Vaccines

Waldemar Debinski

Clin Cancer Res August 15 2005 11 (16) 5663-5664; DOI:10.1158/1078-0432.CCR-05-1101

The Biology Behind

The Biology Behind

Cyclin D1 and Pancreatic Carcinoma: A Proliferative Agonist and Chemotherapeutic Antagonist

J. Alan Diehl and Sharon Benzeno

Clin Cancer Res August 15 2005 11 (16) 5665-5667; DOI:10.1158/1078-0432.CCR-05-1016
The Biology Behind

Epidermal Growth Factor Receptor Mutations in Non–Small Cell Lung Cancer: Predicting Clinical Response to Kinase Inhibitors

Lecia V. Sequist, Daniel A. Haber and Thomas J. Lynch

Clin Cancer Res August 15 2005 11 (16) 5668-5670; DOI:10.1158/1078-0432.CCR-05-1055

Report from the FDA

Report from the FDA

Letrozole in the Extended Adjuvant Treatment of Postmenopausal Women with History of Early-Stage Breast Cancer Who Have Completed 5 Years of Adjuvant Tamoxifen

Bhupinder S. Mann, John R. Johnson, Roswitha Kelly, Rajeshwari Sridhara, Grant Williams and Richard Pazdur

Clin Cancer Res August 15 2005 11 (16) 5671-5677; DOI:10.1158/1078-0432.CCR-05-0354

Human Cancer Biology

Human Cancer Biology

Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy

Roman Rouzier, Charles M. Perou, W. Fraser Symmans, Nuhad Ibrahim, Massimo Cristofanilli, Keith Anderson, Kenneth R. Hess, James Stec, Mark Ayers, Peter Wagner, Paolo Morandi, Chang Fan, Islam Rabiul, Jeffrey S. Ross, Gabriel N. Hortobagyi and Lajos Pusztai

Clin Cancer Res August 15 2005 11 (16) 5678-5685; DOI:10.1158/1078-0432.CCR-04-2421
Human Cancer Biology

CCR7 and CXCR4 as Novel Biomarkers Predicting Axillary Lymph Node Metastasis in T₁ Breast Cancer

Neslihan Cabioglu, M. Sertac Yazici, Banu Arun, Kristine R. Broglio, Gabriel N. Hortobagyi, Janet E. Price and Aysegul Sahin

Clin Cancer Res August 15 2005 11 (16) 5686-5693; DOI:10.1158/1078-0432.CCR-05-0014
Human Cancer Biology

Tissue Distribution of Human Papillomavirus 16 DNA Integration in Patients with Tonsillar Carcinoma

Shahnaz Begum, Dengfeng Cao, Maura Gillison, Marianna Zahurak and William H. Westra

Clin Cancer Res August 15 2005 11 (16) 5694-5699; DOI:10.1158/1078-0432.CCR-05-0587
Human Cancer Biology

A Comparison Study of Different PCR Assays in Measuring Circulating Plasma Epstein-Barr Virus DNA Levels in Patients with Nasopharyngeal Carcinoma

Quynh-Thu Le, Carol D. Jones, Tsz-Kok Yau, Haider A. Shirazi, Priscilla H. Wong, Ella N. Thomas, Bruce K. Patterson, Anne W.M. Lee and James L. Zehnder

Clin Cancer Res August 15 2005 11 (16) 5700-5707; DOI:10.1158/1078-0432.CCR-05-0648
Human Cancer Biology

Expression of Functional B7-H2 and B7.2 Costimulatory Molecules and Their Prognostic Implications in De novo Acute Myeloid Leukemia

Hideto Tamura, Kazuo Dan, Koji Tamada, Kyoko Nakamura, Yumiko Shioi, Hideya Hyodo, Sheng-Dian Wang, Haidong Dong, Lieping Chen and Kiyoyuki Ogata

Clin Cancer Res August 15 2005 11 (16) 5708-5717; DOI:10.1158/1078-0432.CCR-04-2672
Human Cancer Biology

Interleukin-1 and Interleukin-6 Gene Polymorphisms and the Risk of Breast Cancer in Caucasian Women

Lukas A. Hefler, Christoph Grimm, Tilmann Lantzsch, Dieter Lampe, Sepp Leodolter, Heinz Koelbl, Georg Heinze, Alexander Reinthaller, Dan Tong-Cacsire, Clemens Tempfer and Robert Zeillinger

Clin Cancer Res August 15 2005 11 (16) 5718-5721; DOI:10.1158/1078-0432.CCR-05-0001
Human Cancer Biology

Identification of Two Molecular Groups of Seminomas by Using Expression and Tissue Microarrays

Matthias D. Hofer, Tara J. Browne, Le He, Rolf I. Skotheim, Ragnhild A. Lothe and Mark A. Rubin

Clin Cancer Res August 15 2005 11 (16) 5722-5729; DOI:10.1158/1078-0432.CCR-05-0533
Human Cancer Biology

Gene Signatures of Progression and Metastasis in Renal Cell Cancer

Jon Jones, Hasan Otu, Dimitrios Spentzos, Shakirahmed Kolia, Mehmet Inan, Wolf D. Beecken, Christian Fellbaum, Xuesong Gu, Marie Joseph, Allan J. Pantuck, Dietger Jonas and Towia A. Libermann

Clin Cancer Res August 15 2005 11 (16) 5730-5739; DOI:10.1158/1078-0432.CCR-04-2225
Human Cancer Biology

Comprehensive Analysis of CDKN2A Status in Microdissected Urothelial Cell Carcinoma Reveals Potential Haploinsufficiency, a High Frequency of Homozygous Co-deletion and Associations with Clinical Phenotype

Emma J. Chapman, Patricia Harnden, Philip Chambers, Colin Johnston and Margaret A. Knowles

Clin Cancer Res August 15 2005 11 (16) 5740-5747; DOI:10.1158/1078-0432.CCR-05-0411
Human Cancer Biology

Decreased T-Cell Receptor Excision Circles in Cutaneous T-Cell Lymphoma

Kei-ichi Yamanaka, Nikhil Yawalkar, David A. Jones, Daniel Hurwitz, Katalin Ferenczi, Sara Eapen and Thomas S. Kupper

Clin Cancer Res August 15 2005 11 (16) 5748-5755; DOI:10.1158/1078-0432.CCR-04-2514
Human Cancer Biology

The Fragile Histidine Triad Gene: A Molecular Link Between Cigarette Smoking and Cervical Cancer

Christine H. Holschneider, Rae Lynn Baldwin, Kiran Tumber, Chisa Aoyama and Beth Y. Karlan

Clin Cancer Res August 15 2005 11 (16) 5756-5763; DOI:10.1158/1078-0432.CCR-05-0234
Human Cancer Biology

The IgLON Family in Epithelial Ovarian Cancer: Expression Profiles and Clinicopathologic Correlates

Evangelos Ntougkos, Robert Rush, Diane Scott, Tobias Frankenberg, Hani Gabra, John F. Smyth and Grant C. Sellar

Clin Cancer Res August 15 2005 11 (16) 5764-5768; DOI:10.1158/1078-0432.CCR-04-2388
Human Cancer Biology

WOX1 Is Essential for UVB Irradiation–Induced Apoptosis and Down-Regulated via Translational Blockade in UVB-Induced Cutaneous Squamous Cell Carcinoma In vivo

Feng-Jie Lai, Ching-Li Cheng, Shur-Tzu Chen, Chin-Han Wu, Li-Jin Hsu, J. Yu-Yun Lee, Sheau-Chiou Chao, Maw-Chang Sheen, Ching-Liang Shen, Nan-Shan Chang and Hamm-Ming Sheu

Clin Cancer Res August 15 2005 11 (16) 5769-5777; DOI:10.1158/1078-0432.CCR-04-2274
Human Cancer Biology

Expression of Autocrine Motility Factor Correlates with the Angiogenic Phenotype of and Poor Prognosis for Human Gastric Cancer

Weida Gong, Yixing Jiang, Liwei Wang, Daoyan Wei, James Yao, Suyun Huang, Shengyun Fang and Keping Xie

Clin Cancer Res August 15 2005 11 (16) 5778-5783; DOI:10.1158/1078-0432.CCR-05-0214
Human Cancer Biology

Phosphorylation of the 6-Phosphofructo-2-Kinase/Fructose 2,6-Bisphosphatase/PFKFB3 Family of Glycolytic Regulators in Human Cancer

Hidenori Bando, Toshiya Atsumi, Taro Nishio, Hirokatsu Niwa, Shinya Mishima, Chikara Shimizu, Narihito Yoshioka, Richard Bucala and Takao Koike

Clin Cancer Res August 15 2005 11 (16) 5784-5792; DOI:10.1158/1078-0432.CCR-05-0149
Human Cancer Biology

Cytochrome P450 1B1 Is Overexpressed and Regulated by Hypomethylation in Prostate Cancer

Takashi Tokizane, Hiroaki Shiina, Mikio Igawa, Hideki Enokida, Shinji Urakami, Toshifumi Kawakami, Tatsuya Ogishima, Steven T. Okino, Long-Cheng Li, Yuichiro Tanaka, Norio Nonomura, Akihiko Okuyama and Rajvir Dahiya

Clin Cancer Res August 15 2005 11 (16) 5793-5801; DOI:10.1158/1078-0432.CCR-04-2545
Human Cancer Biology

Role of Mononuclear Cells and Inflammatory Cytokines in Pancreatic Cancer-Related Cachexia

Marc E. Martignoni, Phillipp Kunze, Wulf Hildebrandt, Beat Künzli, Pascal Berberat, Thomas Giese, Oliver Klöters, Jürgen Hammer, Markus W. Büchler, Nathalia A. Giese and Helmut Friess

Clin Cancer Res August 15 2005 11 (16) 5802-5808; DOI:10.1158/1078-0432.CCR-05-0185
Human Cancer Biology

Cyr61 Induces Gastric Cancer Cell Motility/Invasion via Activation of the Integrin/Nuclear Factor-κB/Cyclooxygenase-2 Signaling Pathway

Ming-Tsai Lin, Chung-Yaou Zuon, Cheng-Chi Chang, Szu-Ta Chen, Chih-Ping Chen, Been-Ren Lin, Ming-Yang Wang, Yung-Ming Jeng, King-Jen Chang, Po-Huang Lee, Wei-Jao Chen and Min-Liang Kuo

Clin Cancer Res August 15 2005 11 (16) 5809-5820; DOI:10.1158/1078-0432.CCR-04-2639
Human Cancer Biology

Alteration of Gene Expression in Human Hepatocellular Carcinoma with Integrated Hepatitis B Virus DNA

Akihiro Tamori, Yoshihiro Yamanishi, Shuichi Kawashima, Minoru Kanehisa, Masaru Enomoto, Hiromu Tanaka, Shoji Kubo, Susumu Shiomi and Shuhei Nishiguchi

Clin Cancer Res August 15 2005 11 (16) 5821-5826; DOI:10.1158/1078-0432.CCR-04-2055

Imaging, Diagnosis, Prognosis

Imaging, Diagnosis, Prognosis

Early Antiangiogenic Activity of SU11248 Evaluated In vivo by Dynamic Contrast-Enhanced Magnetic Resonance Imaging in an Experimental Model of Colon Carcinoma

Pasquina Marzola, Anna Degrassi, Laura Calderan, Paolo Farace, Elena Nicolato, Caterina Crescimanno, Marco Sandri, Anna Giusti, Enrico Pesenti, Andrea Terron, Andrea Sbarbati and Francesco Osculati

Clin Cancer Res August 15 2005 11 (16) 5827-5832; DOI:10.1158/1078-0432.CCR-04-2655
Imaging, Diagnosis, Prognosis

Characterization of a New Antibody Raised against the NH₂ Terminus of P-Glycoprotein

Prema S. Rao, Rajgopal Govindarajan, Kavita B. Mallya, William West and U. Subrahmanyeswara Rao

Clin Cancer Res August 15 2005 11 (16) 5833-5839; DOI:10.1158/1078-0432.CCR-04-2182
Imaging, Diagnosis, Prognosis

New Monoclonal Antibodies to Mesothelin Useful for Immunohistochemistry, Fluorescence-Activated Cell Sorting, Western Blotting, and ELISA

Masanori Onda, Mark Willingham, Satoshi Nagata, Tapan K. Bera, Richard Beers, Mitchell Ho, Raffit Hassan, Robert J. Kreitman and Ira Pastan

Clin Cancer Res August 15 2005 11 (16) 5840-5846; DOI:10.1158/1078-0432.CCR-05-0578
Imaging, Diagnosis, Prognosis

Proteomic Analysis of Apoptotic Pathways Reveals Prognostic Factors in Follicular Lymphoma

Christian Gulmann, Virginia Espina, Emanuel Petricoin III, Dan L. Longo, Mariarita Santi, Turid Knutsen, Mark Raffeld, Elaine S. Jaffe, Lance A. Liotta and Andrew L. Feldman

Clin Cancer Res August 15 2005 11 (16) 5847-5855; DOI:10.1158/1078-0432.CCR-05-0637
Imaging, Diagnosis, Prognosis

Quantitative Determination of Nuclear and Cytoplasmic Epidermal Growth Factor Receptor Expression in Oropharyngeal Squamous Cell Cancer by Using Automated Quantitative Analysis

Amanda Psyrri, Ziwei Yu, Paul M. Weinberger, Clarence Sasaki, Bruce Haffty, Robert Camp, David Rimm and Barbara Ann Burtness

Clin Cancer Res August 15 2005 11 (16) 5856-5862; DOI:10.1158/1078-0432.CCR-05-0420
Imaging, Diagnosis, Prognosis

Activation of Signal Transducer and Activator of Transcription-5 in Prostate Cancer Predicts Early Recurrence

Hongzhen Li, Ying Zhang, Andrew Glass, Tobias Zellweger, Edmund Gehan, Lukas Bubendorf, Edward P. Gelmann and Marja T. Nevalainen

Clin Cancer Res August 15 2005 11 (16) 5863-5868; DOI:10.1158/1078-0432.CCR-05-0562
Imaging, Diagnosis, Prognosis

P-Cadherin Overexpression Is an Indicator of Clinical Outcome in Invasive Breast Carcinomas and Is Associated with CDH3 Promoter Hypomethylation

Joana Paredes, André Albergaria, João T. Oliveira, Carmen Jerónimo, Fernanda Milanezi and Fernando C. Schmitt

Clin Cancer Res August 15 2005 11 (16) 5869-5877; DOI:10.1158/1078-0432.CCR-05-0059
Imaging, Diagnosis, Prognosis

Activating Mutations in the Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor Are Associated with Improved Survival in Gefitinib-Treated Chemorefractory Lung Adenocarcinomas

Miguel Taron, Yukito Ichinose, Rafael Rosell, Tony Mok, Bartomeu Massuti, Lurdes Zamora, Jose Luis Mate, Christian Manegold, Mayumi Ono, Cristina Queralt, Thierry Jahan, Jose Javier Sanchez, Maria Sanchez-Ronco, Victor Hsue, David Jablons, Jose Miguel Sanchez and Teresa Moran

Clin Cancer Res August 15 2005 11 (16) 5878-5885; DOI:10.1158/1078-0432.CCR-04-2618

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Analysis of the DPYD Gene Implicated in 5-Fluorouracil Catabolism in a Cohort of Caucasian Individuals

Katharina Seck, Silvia Riemer, Ronald Kates, Tobias Ullrich, Verena Lutz, Nadia Harbeck, Manfred Schmitt, Marion Kiechle, Robert Diasio and Eva Gross

Clin Cancer Res August 15 2005 11 (16) 5886-5892; DOI:10.1158/1078-0432.CCR-04-1784
Cancer Therapy: Clinical

Pharmacokinetics of Dactinomycin in a Pediatric Patient Population: a United Kingdom Children's Cancer Study Group Study

Gareth J. Veal, Michael Cole, Julie Errington, Annie Parry, Juliet Hale, Andrew D.J. Pearson, Karen Howe, Julia C. Chisholm, Carol Beane, Bernadette Brennan, Fiona Waters, Adam Glaser, Sue Hemsworth, Heather McDowell, Yvonne Wright, Kathy Pritchard-Jones, Ross Pinkerton, Gail Jenner, James Nicholson, Ann M. Elsworth, Alan V. Boddy and UKCCSG Pharmacology Working Group

Clin Cancer Res August 15 2005 11 (16) 5893-5899; DOI:10.1158/1078-0432.CCR-04-2546
Cancer Therapy: Clinical

Immunologic Evaluation of Personalized Peptide Vaccination for Patients with Advanced Malignant Glioma

Naoki Yajima, Ryuya Yamanaka, Takashi Mine, Naoto Tsuchiya, Jumpei Homma, Masakazu Sano, Terukazu Kuramoto, Yayoi Obata, Nobukazu Komatsu, Yoshimi Arima, Akira Yamada, Minoru Shigemori, Kyogo Itoh and Ryuichi Tanaka

Clin Cancer Res August 15 2005 11 (16) 5900-5911; DOI:10.1158/1078-0432.CCR-05-0559
Cancer Therapy: Clinical

Phase I Study of Combined Pegylated Liposomal Doxorubicin with Protracted Daily Topotecan for Ovarian Cancer

Deepu Mirchandani, Howard Hochster, Anne Hamilton, Leonard Liebes, Herman Yee, John P. Curtin, Sang Lee, Joan Sorich, Cornelia Dellenbaugh and Franco M. Muggia

Clin Cancer Res August 15 2005 11 (16) 5912-5919; DOI:10.1158/1078-0432.CCR-04-1240
Cancer Therapy: Clinical

High-Dose Radioimmunotherapy Combined with Fixed, Low-Dose Paclitaxel in Metastatic Prostate and Breast Cancer by Using a MUC-1 Monoclonal Antibody, m170, Linked to Indium-111/Yttrium-90 via a Cathepsin Cleavable Linker with Cyclosporine to Prevent Human Anti-mouse Antibody

Carol M. Richman, Sally J. DeNardo, Robert T. O'Donnell, Aina Yuan, Sui Shen, Desiree S. Goldstein, Joseph M. Tuscano, Ted Wun, Helen K. Chew, Primo N. Lara, David L. Kukis, Arutselvan Natarajan, Claude F. Meares, Kathleen R. Lamborn and Gerald L. DeNardo

Clin Cancer Res August 15 2005 11 (16) 5920-5927; DOI:10.1158/1078-0432.CCR-05-0211
Cancer Therapy: Clinical

Objective Responses in Patients with Malignant Melanoma or Renal Cell Cancer in Early Clinical Studies Do Not Predict Regulatory Approval

John Goffin, Stefan Baral, Dongsheng Tu, Dora Nomikos and Lesley Seymour

Clin Cancer Res August 15 2005 11 (16) 5928-5934; DOI:10.1158/1078-0432.CCR-05-0130
Cancer Therapy: Clinical

Phase 1 Trial of Flavopiridol Combined with Cisplatin or Carboplatin in Patients with Advanced Malignancies with the Assessment of Pharmacokinetic and Pharmacodynamic End Points

Keith C. Bible, Janet L. Lensing, Sacha A. Nelson, Yean K. Lee, Joel M. Reid, Matthew M. Ames, Crescent R. Isham, Jill Piens, Stacie L. Rubin, Joseph Rubin, Scott H. Kaufmann, Pamela J. Atherton, Jeffrey A. Sloan, Michelle K. Daiss, Alex A. Adjei and Charles Erlichman

Clin Cancer Res August 15 2005 11 (16) 5935-5941; DOI:10.1158/1078-0432.CCR-04-2566
Cancer Therapy: Clinical

Phase I and Pharmacokinetic Study of Weekly Docetaxel, Cisplatin, and Daily Capecitabine in Patients with Advanced Solid Tumors

Marwan G. Fakih, Patrick J. Creaven, Nithya Ramnath, Donald Trump, Milind Javle, Sandra Strychor, Trisha V.W. Repinski, Beth A. Zamboni, James K. Schwarz, Renee A. French and William C. Zamboni

Clin Cancer Res August 15 2005 11 (16) 5942-5949; DOI:10.1158/1078-0432.CCR-05-0116

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

CpG Immunomer DNA Enhances Antisense Protein Kinase A RIα Inhibition of Multidrug-Resistant Colon Carcinoma Growth in Nude Mice: Molecular Basis for Combinatorial Therapy

Maria V. Nesterova, Natalie R. Johnson, Trina Stewart, Scott Abrams and Yoon S. Cho-Chung

Clin Cancer Res August 15 2005 11 (16) 5950-5955; DOI:10.1158/1078-0432.CCR-05-0624
Cancer Therapy: Preclinical

Radiation and Transforming Growth Factor-β Cooperate in Transcriptional Activation of the Profibrotic Plasminogen Activator Inhibitor-1 Gene

Jurre Hageman, Bart J. Eggen, Tom Rozema, Kevin Damman, Harm H. Kampinga and Robert P. Coppes

Clin Cancer Res August 15 2005 11 (16) 5956-5964; DOI:10.1158/1078-0432.CCR-05-0427
Cancer Therapy: Preclinical

PEX-Producing Human Neural Stem Cells Inhibit Tumor Growth in a Mouse Glioma Model

Seung-Ki Kim, Theresa G. Cargioli, Marcelle Machluf, Wendy Yang, Yanping Sun, Ruqayyah Al-Hashem, Seung U. Kim, Peter M. Black and Rona S. Carroll

Clin Cancer Res August 15 2005 11 (16) 5965-5970; DOI:10.1158/1078-0432.CCR-05-0371
Cancer Therapy: Preclinical

Generation of Rituximab Polymer May Cause Hyper-Cross-linking–Induced Apoptosis in Non-Hodgkin's Lymphomas

Nan Zhang, Leslie A. Khawli, Peisheng Hu and Alan L. Epstein

Clin Cancer Res August 15 2005 11 (16) 5971-5980; DOI:10.1158/1078-0432.CCR-05-0554
Cancer Therapy: Preclinical

Plasma and Cerebrospinal Fluid Pharmacokinetics of Clofarabine in Nonhuman Primates

Stacey L. Berg, Peter L. Bonate, Jed G. Nuchtern, Robert Dauser, Leticia McGuffey, Bruce Bernacky and Susan M. Blaney

Clin Cancer Res August 15 2005 11 (16) 5981-5983; DOI:10.1158/1078-0432.CCR-05-0261
Cancer Therapy: Preclinical

Immunomodulatory Drug CC-5013 or CC-4047 and Rituximab Enhance Antitumor Activity in a Severe Combined Immunodeficient Mouse Lymphoma Model

Francisco J. Hernandez-Ilizaliturri, Nishitha Reddy, Beata Holkova, Edris Ottman and Myron S. Czuczman

Clin Cancer Res August 15 2005 11 (16) 5984-5992; DOI:10.1158/1078-0432.CCR-05-0577
Cancer Therapy: Preclinical

Phase I/II Combined Chemoimmunotherapy with Carcinoembryonic Antigen–Derived HLA-A2–Restricted CAP-1 Peptide and Irinotecan, 5-Fluorouracil, and Leucovorin in Patients with Primary Metastatic Colorectal Cancer

Martin R. Weihrauch, Sascha Ansén, Elke Jurkiewicz, Caroline Geisen, Zhinan Xia, Karen S. Anderson, Edith Gracien, Manuel Schmidt, Burghardt Wittig, Volker Diehl, Juergen Wolf, Heribert Bohlen and Lee M. Nadler

Clin Cancer Res August 15 2005 11 (16) 5993-6001; DOI:10.1158/1078-0432.CCR-05-0018
Cancer Therapy: Preclinical

Pseudolaric Acid B, a Novel Microtubule-Destabilizing Agent That Circumvents Multidrug Resistance Phenotype and Exhibits Antitumor Activity In vivo

Vincent K.W. Wong, Pauline Chiu, Stephen S.M. Chung, Larry M.C. Chow, Yun-Zhe Zhao, Burton B. Yang and Ben C.B. Ko

Clin Cancer Res August 15 2005 11 (16) 6002-6011; DOI:10.1158/1078-0432.CCR-05-0209
Cancer Therapy: Preclinical

Targeting Matrilysin and Its Impact on Tumor Growth In vivo: The Potential Implications in Breast Cancer Therapy

Wen G. Jiang, Gaynor Davies, Tracey A. Martin, Christian Parr, Gareth Watkins, Malcolm D. Mason, Kefah Mokbel and Robert E. Mansel

Clin Cancer Res August 15 2005 11 (16) 6012-6019; DOI:10.1158/1078-0432.CCR-05-0275
Cancer Therapy: Preclinical

Adeno-Associated Virus Vector-Mediated Systemic Delivery of IFN-β Combined with Low-Dose Cyclophosphamide Affects Tumor Regression in Murine Neuroblastoma Models

Christian J. Streck, Paxton V. Dickson, Catherine Y.C. Ng, Junfang Zhou, John T. Gray, Amit C. Nathwani and Andrew M. Davidoff

Clin Cancer Res August 15 2005 11 (16) 6020-6029; DOI:10.1158/1078-0432.CCR-05-0502
Cancer Therapy: Preclinical

Indoleamine 2,3-Dioxygenase Serves as a Marker of Poor Prognosis in Gene Expression Profiles of Serous Ovarian Cancer Cells

Aikou Okamoto, Takashi Nikaido, Kazunori Ochiai, Satoshi Takakura, Misato Saito, Yuko Aoki, Nobuya Ishii, Nozomu Yanaihara, Kyosuke Yamada, Osamu Takikawa, Rie Kawaguchi, Seiji Isonishi, Tadao Tanaka and Mitsuyoshi Urashima

Clin Cancer Res August 15 2005 11 (16) 6030-6039; DOI:10.1158/1078-0432.CCR-04-2671
Cancer Therapy: Preclinical

Green Tea Component, Catechin, Induces Apoptosis of Human Malignant B Cells via Production of Reactive Oxygen Species

Tomonori Nakazato, Keisuke Ito, Yasuo Ikeda and Masahiro Kizaki

Clin Cancer Res August 15 2005 11 (16) 6040-6049; DOI:10.1158/1078-0432.CCR-04-2273
Cancer Therapy: Preclinical

Genetic Variations in the Glucocorticoid Receptor Gene Are Not Related to Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia

Wim J.E. Tissing, Jules P.P. Meijerink, Monique L. den Boer, Bas Brinkhof, Elisabeth F.C. van Rossum, Elisabeth R. van Wering, Jan W. Koper, Pieter Sonneveld and Rob Pieters

Clin Cancer Res August 15 2005 11 (16) 6050-6056; DOI:10.1158/1078-0432.CCR-04-2097
Cancer Therapy: Preclinical

Characterization of a R115777-Resistant Human Multiple Myeloma Cell Line with Cross-Resistance to PS-341

Robert Buzzeo, Steven Enkemann, Rama Nimmanapalli, Melissa Alsina, Mathias G. Lichtenheld, William S. Dalton and Darrin M. Beaupre

Clin Cancer Res August 15 2005 11 (16) 6057-6064; DOI:10.1158/1078-0432.CCR-04-2685
Cancer Therapy: Preclinical

Response of Non–Small Cell Lung Cancer Cells to the Inhibitors of Phosphatidylinositol 3-Kinase/Akt- and MAPK Kinase 4/c-Jun NH₂-Terminal Kinase Pathways: An Effective Therapeutic Strategy for Lung Cancer

Ho-Young Lee, Seung-Hyun Oh, Young-Ah Suh, Jin Hyen Baek, Vali Papadimitrakopoulou, Suyun Huang and Waun Ki Hong

Clin Cancer Res August 15 2005 11 (16) 6065-6074; DOI:10.1158/1078-0432.CCR-05-0009
Cancer Therapy: Preclinical

Overexpression of Cyclin D1 Promotes Tumor Cell Growth and Confers Resistance to Cisplatin-Mediated Apoptosis in an Elastase-myc Transgene–Expressing Pancreatic Tumor Cell Line

Hector Biliran Jr., Yong Wang, Sanjeev Banerjee, Haiming Xu, Henry Heng, Archana Thakur, Aliccia Bollig, Fazlul H. Sarkar and Joshua D. Liao

Clin Cancer Res August 15 2005 11 (16) 6075-6086; DOI:10.1158/1078-0432.CCR-04-2419

Cancer Prevention

Cancer Prevention

Levels of Prostaglandin E Metabolite, the Major Urinary Metabolite of Prostaglandin E₂, Are Increased in Smokers

Neil D. Gross, Jay O. Boyle, Jason D. Morrow, Myles K. Williams, Chaya S. Moskowitz, Kotha Subbaramaiah, Andrew J. Dannenberg and Anna J. Duffield-Lillico

Clin Cancer Res August 15 2005 11 (16) 6087-6093; DOI:10.1158/1078-0432.CCR-05-0733

Letters to the Editor

Letters to the Editor

The Potential and Suitability of 2-Methoxyestradiol in Cancer Therapy

Carolyn Sidor, Robert D'Amato and Kathy D. Miller

Clin Cancer Res August 15 2005 11 (16) 6094-6096; DOI:10.1158/1078-0432.CCR-05-0724

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