In the article on sodium channels and breast cancer metastasis in the August 1, 2005, issue of Clinical Cancer Research, the dose response curve in Fig. 1B was incorrectly represented. The correct Figure 1 appears below.
Voltage-gated membrane currents in a human breast epithelial cell line and human breast cancer cells. A, voltage-gated membrane currents recorded in (left to right)MCF-10A,MCF-7,MDA-MB-468, andMDA-MB-231 cells. The currents were generated by pulsing the membrane potential from a holding voltage of −100 mV, in 5 mV steps, from −60 to +60 mV for 200 ms. Voltage pulses were applied with a repeat interval of 20 seconds. Every second current trace generated is displayed. B, dose-response curve for the effects of tetrodotoxin (TTX) on the VGSC current in MDA-MB-231cells. The percentage reduction of the peak current at the fourth pulse (to −10 mV) following drug application was plotted as a function of drug concentration. Points, means of >5 different cells; bars, SE. Inset, a typical effect (and recovery) of one concentration of the drug on the inward current. B, the holding potential was −100 mV; the cell was pulsed repeatedly to −10 mV for 40 milliseconds every 20 seconds. The effect of tetrodotoxin was recorded from the fourth pulse following application.
Fraser SP, Diss JKJ, Chioni A-M, et al. Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis. Clin Cancer Res 2005;11:5381–9.
Volume 11, Issue 22
