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Clinical Cancer Research
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Table of Contents

Editorial

  • Editorial
    Effective Strategies for Tumors Affecting Chemopreventive Metabolism
    Jeroen T.M. Buters
    Clin Cancer Res December 15 2006 12 (24) 7203-7204; DOI:10.1158/1078-0432.CCR-06-1752

The Biology Behind

  • The Biology Behind
    Circulating Methylated DNA: A New Generation of Tumor Markers
    Martin Widschwendter and Usha Menon
    Clin Cancer Res December 15 2006 12 (24) 7205-7208; DOI:10.1158/1078-0432.CCR-06-2531

CCR Practice of Translational Oncology

  • CCR Practice of Translational Oncology
    Chips to Bedside: Incorporation of Microarray Data into Clinical Practice
    Lajos Pusztai
    Clin Cancer Res December 15 2006 12 (24) 7209-7214; DOI:10.1158/1078-0432.CCR-06-2649

Molecular Pathways

  • Molecular Pathways
    Targeting von Hippel-Lindau Pathway in Renal Cell Carcinoma
    Premal H. Patel, Rajendrakumar S.V. Chadalavada, R.S.K. Chaganti and Robert J. Motzer
    Clin Cancer Res December 15 2006 12 (24) 7215-7220; DOI:10.1158/1078-0432.CCR-06-2254

CCR Focus

  • CCR Focus
    From the Editor
    Susan E. Bates
    Clin Cancer Res December 15 2006 12 (24) 7221-7221; DOI:10.1158/1078-0432.CCR-12-24-INT

  • CCR Focus
    Epidermal Growth Factor Receptor Activation: How Exon 19 and 21 Mutations Changed Our Understanding of the Pathway
    Rafael Rosell, Miquel Taron, Noemi Reguart, Dolores Isla and Teresa Moran
    Clin Cancer Res December 15 2006 12 (24) 7222-7231; DOI:10.1158/1078-0432.CCR-06-0627

  • CCR Focus
    Update on Epidermal Growth Factor Receptor Mutations in Non–Small Cell Lung Cancer
    Gregory J. Riely, Katerina A. Politi, Vincent A. Miller and William Pao
    Clin Cancer Res December 15 2006 12 (24) 7232-7241; DOI:10.1158/1078-0432.CCR-06-0658

  • CCR Focus
    Molecular Mechanisms of Epidermal Growth Factor Receptor (EGFR) Activation and Response to Gefitinib and Other EGFR-Targeting Drugs
    Mayumi Ono and Michihiko Kuwano
    Clin Cancer Res December 15 2006 12 (24) 7242-7251; DOI:10.1158/1078-0432.CCR-06-0646

  • CCR Focus
    Mechanisms of egfr Gene Transcription Modulation: Relationship to Cancer Risk and Therapy Response
    Burkhard Brandt, Sönke Meyer-Staeckling, Hartmut Schmidt, Konstantin Agelopoulos and Horst Buerger
    Clin Cancer Res December 15 2006 12 (24) 7252-7260; DOI:10.1158/1078-0432.CCR-06-0626

  • CCR Focus
    Epidermal Growth Factor Receptor–Mediated Signal Transduction in the Development and Therapy of Gliomas
    M. Kelly Nicholas, Rimas V. Lukas, Nazia F. Jafri, Leonardo Faoro and Ravi Salgia
    Clin Cancer Res December 15 2006 12 (24) 7261-7270; DOI:10.1158/1078-0432.CCR-06-0874

Report from FDA

  • Report from FDA
    Sorafenib for the Treatment of Advanced Renal Cell Carcinoma
    Robert C. Kane, Ann T. Farrell, Haleh Saber, Shenghui Tang, Gene Williams, Josephine M. Jee, Chengyi Liang, Brian Booth, Nallaperumal Chidambaram, David Morse, Rajeshwari Sridhara, Patricia Garvey, Robert Justice and Richard Pazdur
    Clin Cancer Res December 15 2006 12 (24) 7271-7278; DOI:10.1158/1078-0432.CCR-06-1249

Perspective

  • Perspective
    Maspin: The New Frontier
    Zhila Khalkhali-Ellis
    Clin Cancer Res December 15 2006 12 (24) 7279-7283; DOI:10.1158/1078-0432.CCR-06-1589

Human Cancer Biology

  • Human Cancer Biology
    Amplification and Overexpression of CACNA1E Correlates with Relapse in Favorable Histology Wilms' Tumors
    Rachael Natrajan, Suzanne E. Little, Jorge S. Reis-Filho, Lara Hing, Boo Messahel, Paul E. Grundy, Jeffrey S. Dome, Toni Schneider, Gordan M. Vujanic, Kathy Pritchard-Jones and Chris Jones
    Clin Cancer Res December 15 2006 12 (24) 7284-7293; DOI:10.1158/1078-0432.CCR-06-1567

  • Human Cancer Biology
    β2-Microglobulin Promotes the Growth of Human Renal Cell Carcinoma through the Activation of the Protein Kinase A, Cyclic AMP–Responsive Element-Binding Protein, and Vascular Endothelial Growth Factor Axis
    Takeo Nomura, Wen-Chin Huang, Haiyen E. Zhau, Daqing Wu, Zhihui Xie, Hiromitsu Mimata, Majd Zayzafoon, Andrew N. Young, Fray F. Marshall, M. Neale Weitzmann and Leland W.K. Chung
    Clin Cancer Res December 15 2006 12 (24) 7294-7305; DOI:10.1158/1078-0432.CCR-06-2060

  • Human Cancer Biology
    Profiling of CD4+, CD8+, and CD4+CD25+CD45RO+FoxP3+ T Cells in Patients with Malignant Glioma Reveals Differential Expression of the Immunologic Transcriptome Compared with T Cells from Healthy Volunteers
    Chris A. Learn, Peter E. Fecci, Robert J. Schmittling, Weihua Xie, Isaac Karikari, Duane A. Mitchell, Gary E. Archer, ZhengZheng Wei, Holly Dressman and John H. Sampson
    Clin Cancer Res December 15 2006 12 (24) 7306-7315; DOI:10.1158/1078-0432.CCR-06-1727

  • Human Cancer Biology
    The Coamplification Pattern of the MYCN Amplicon Is an Invariable Attribute of Most MYCN-Amplified Human Neuroblastomas
    Axel Weber, Sven Starke, Eckhard Bergmann and Holger Christiansen
    Clin Cancer Res December 15 2006 12 (24) 7316-7321; DOI:10.1158/1078-0432.CCR-06-0837

Imaging, Diagnosis, Prognosis

  • Imaging, Diagnosis, Prognosis
    RNASEN Regulates Cell Proliferation and Affects Survival in Esophageal Cancer Patients
    Nobuyoshi Sugito, Hideyuki Ishiguro, Yoshiyuki Kuwabara, Masahiro Kimura, Akira Mitsui, Hiroki Kurehara, Takuya Ando, Ryota Mori, Nobuhiro Takashima, Ryo Ogawa and Yoshitaka Fujii
    Clin Cancer Res December 15 2006 12 (24) 7322-7328; DOI:10.1158/1078-0432.CCR-06-0515

  • Imaging, Diagnosis, Prognosis
    Aberrant Promoter Methylation Profile and Association with Survival in Patients with Non–Small Cell Lung Cancer
    Jian Gu, David Berman, Charles Lu, Ignacio I. Wistuba, Jack A. Roth, Marsha Frazier, Margaret R. Spitz and Xifeng Wu
    Clin Cancer Res December 15 2006 12 (24) 7329-7338; DOI:10.1158/1078-0432.CCR-06-0894

  • Imaging, Diagnosis, Prognosis
    Vascular Cell Adhesion Molecule 1 Predicts Cancer-Free Survival in Clear Cell Renal Carcinoma Patients
    Ko-ichi Shioi, Atsushi Komiya, Keiko Hattori, Ying Huang, Futoshi Sano, Takayuki Murakami, Noboru Nakaigawa, Takeshi Kishida, Yoshinobu Kubota, Yoji Nagashima and Masahiro Yao
    Clin Cancer Res December 15 2006 12 (24) 7339-7346; DOI:10.1158/1078-0432.CCR-06-1737

  • Imaging, Diagnosis, Prognosis
    Methylation of Serum DNA Is an Independent Prognostic Marker in Colorectal Cancer
    Maike Wallner, Andreas Herbst, Andrea Behrens, Alexander Crispin, Petra Stieber, Burkhard Göke, Rolf Lamerz and Frank T. Kolligs
    Clin Cancer Res December 15 2006 12 (24) 7347-7352; DOI:10.1158/1078-0432.CCR-06-1264

  • Imaging, Diagnosis, Prognosis
    Implications of Methylation Patterns of Cancer Genes in Salivary Gland Tumors
    Michelle D. Williams, Nitin Chakravarti, Merrill S. Kies, Shin-Ichiro Maruya, Jeffrey N. Myers, Joie C. Haviland, Randal S. Weber, Reuben Lotan and Adel K. El-Naggar
    Clin Cancer Res December 15 2006 12 (24) 7353-7358; DOI:10.1158/1078-0432.CCR-06-1272

  • Imaging, Diagnosis, Prognosis
    Molecular Profiling of ADAM12 in Human Bladder Cancer
    Camilla Fröhlich, Reidar Albrechtsen, Lars Dyrskjøt, Lise Rudkjær, Torben F. Ørntoft and Ulla M. Wewer
    Clin Cancer Res December 15 2006 12 (24) 7359-7368; DOI:10.1158/1078-0432.CCR-06-1066

  • Imaging, Diagnosis, Prognosis
    Ki-67 Is an Independent Predictor of Bladder Cancer Outcome in Patients Treated with Radical Cystectomy for Organ-Confined Disease
    Vitaly Margulis, Shahrokh F. Shariat, Raheela Ashfaq, Arthur I. Sagalowsky and Yair Lotan
    Clin Cancer Res December 15 2006 12 (24) 7369-7373; DOI:10.1158/1078-0432.CCR-06-1472

Cancer Therapy: Clinical

  • Cancer Therapy: Clinical
    Contribution of ABL Kinase Domain Mutations to Imatinib Resistance in Different Subsets of Philadelphia-Positive Patients: By the GIMEMA Working Party on Chronic Myeloid Leukemia
    Simona Soverini, Sabrina Colarossi, Alessandra Gnani, Gianantonio Rosti, Fausto Castagnetti, Angela Poerio, Ilaria Iacobucci, Marilina Amabile, Elisabetta Abruzzese, Ester Orlandi, Franca Radaelli, Fabrizio Ciccone, Mario Tiribelli, Roberto di Lorenzo, Clementina Caracciolo, Barbara Izzo, Fabrizio Pane, Giuseppe Saglio, Michele Baccarani, Giovanni Martinelli and ; on behalf of the GIMEMA Working Party on Chronic Myeloid Leukemia
    Clin Cancer Res December 15 2006 12 (24) 7374-7379; DOI:10.1158/1078-0432.CCR-06-1516

  • Cancer Therapy: Clinical
    Immunologic and Clinical Effects of Injecting Mature Peptide-Loaded Dendritic Cells by Intralymphatic and Intranodal Routes in Metastatic Melanoma Patients
    Thierry Lesimple, Eve-Marie Neidhard, Virginie Vignard, Claudia Lefeuvre, Henri Adamski, Nathalie Labarrière, André Carsin, Delphine Monnier, Brigitte Collet, Gilles Clapisson, Brigitte Birebent, Irène Philip, Louis Toujas, Mohamed Chokri and Véronique Quillien
    Clin Cancer Res December 15 2006 12 (24) 7380-7388; DOI:10.1158/1078-0432.CCR-06-1879

  • Cancer Therapy: Clinical
    A Neoadjuvant/Adjuvant Randomized Trial of Colorectal Cancer Patients Vaccinated with an Anti-Idiotypic Antibody, 105AD7, Mimicking CD55
    Gustav J. Ullenhag, Ian Spendlove, Nicholas F.S. Watson, Adrian A. Indar, Mukul Dube, Richard A. Robins, Charles Maxwell-Armstrong, John H. Scholefield and Lindy G. Durrant
    Clin Cancer Res December 15 2006 12 (24) 7389-7396; DOI:10.1158/1078-0432.CCR-06-1003

  • Cancer Therapy: Clinical
    HER2-Specific T-Cell Immune Responses in Patients Vaccinated with Truncated HER2 Protein Complexed with Nanogels of Cholesteryl Pullulan
    Shigehisa Kitano, Shinichi Kageyama, Yasuhiro Nagata, Yoshihiro Miyahara, Atsunori Hiasa, Hiroaki Naota, Satoshi Okumura, Hiroshi Imai, Taizo Shiraishi, Masahiro Masuya, Masakatsu Nishikawa, Junzo Sunamoto, Kazunari Akiyoshi, Takashi Kanematsu, Andrew M. Scott, Roger Murphy, Eric W. Hoffman, Lloyd J. Old and Hiroshi Shiku
    Clin Cancer Res December 15 2006 12 (24) 7397-7405; DOI:10.1158/1078-0432.CCR-06-1546

  • Cancer Therapy: Clinical
    Phase I, Pharmacokinetic, and Biological Study of Erlotinib in Combination with Paclitaxel and Carboplatin in Patients with Advanced Solid Tumors
    Amita Patnaik, Debra Wood, Anthony W. Tolcher, Marta Hamilton, Jeffrey I. Kreisberg, Lisa A. Hammond, Garry Schwartz, Muralidhar Beeram, Manuel Hidalgo, Monica M. Mita, Julie Wolf, Paul Nadler and Eric K. Rowinsky
    Clin Cancer Res December 15 2006 12 (24) 7406-7413; DOI:10.1158/1078-0432.CCR-06-1886

  • Cancer Therapy: Clinical
    Rapid Androgen Cycling as Treatment for Patients with Prostate Cancer
    David Feltquate, Luke Nordquist, Caitlin Eicher, Michael Morris, Oren Smaletz, Susan Slovin, Tracy Curley, Andrew Wilton, Martin Fleisher, Glenn Heller and Howard I. Scher
    Clin Cancer Res December 15 2006 12 (24) 7414-7421; DOI:10.1158/1078-0432.CCR-06-1496

Cancer Therapy: Preclinical

  • Cancer Therapy: Preclinical
    Active Antiviral T-Lymphocyte Response Can Be Redirected against Tumor Cells by Antitumor Antibody × MHC/Viral Peptide Conjugates
    Valérie Cesson, Kathrin Stirnemann, Bruno Robert, Immanuel Luescher, Thomas Filleron, Giampietro Corradin, Jean-Pierre Mach and Alena Donda
    Clin Cancer Res December 15 2006 12 (24) 7422-7430; DOI:10.1158/1078-0432.CCR-06-1862

  • Cancer Therapy: Preclinical
    Inhibitory Effects of Castration in an Orthotopic Model of Androgen-Independent Prostate Cancer Can Be Mimicked and Enhanced by Angiogenesis Inhibition
    Peter Hammarsten, Sofia Halin, Pernilla Wikstöm, Roger Henriksson, Stina Häggström Rudolfsson and Anders Bergh
    Clin Cancer Res December 15 2006 12 (24) 7431-7436; DOI:10.1158/1078-0432.CCR-06-1895

  • Cancer Therapy: Preclinical
    Systemic Anthrax Lethal Toxin Therapy Produces Regressions of Subcutaneous Human Melanoma Tumors in Athymic Nude Mice
    Ralph J. Abi-Habib, Ravibhushan Singh, Stephen H. Leppla, John J. Greene, Yan Ding, Bree Berghuis, Nicholas S. Duesbery and Arthur E. Frankel
    Clin Cancer Res December 15 2006 12 (24) 7437-7443; DOI:10.1158/1078-0432.CCR-06-2019

  • Cancer Therapy: Preclinical
    Preclinical Evaluation of Antiangiogenic Thrombospondin-1 Peptide Mimetics, ABT-526 and ABT-510, in Companion Dogs with Naturally Occurring Cancers
    Anthony Rusk, Evelyn McKeegan, Fortuna Haviv, Sandra Majest, Jack Henkin and Chand Khanna
    Clin Cancer Res December 15 2006 12 (24) 7444-7455; DOI:10.1158/1078-0432.CCR-06-0109

  • Cancer Therapy: Preclinical
    Cooperative Activity of Cytotoxic Chemotherapy with Antiangiogenic Thrombospondin-I Peptides, ABT-526 in Pet Dogs with Relapsed Lymphoma
    Anthony Rusk, Elizabeth Cozzi, Marty Stebbins, David Vail, Joanne Graham, Victor Valli, Jack Henkin, Rick Sharpee and Chand Khanna
    Clin Cancer Res December 15 2006 12 (24) 7456-7464; DOI:10.1158/1078-0432.CCR-06-0110

  • Cancer Therapy: Preclinical
    Enhancement of Immunologic Tumor Regression by Intratumoral Administration of Dendritic Cells in Combination with Cryoablative Tumor Pretreatment and Bacillus Calmette-Guerin Cell Wall Skeleton Stimulation
    Masaru Udagawa, Chie Kudo-Saito, Go Hasegawa, Kazuhito Yano, Aiko Yamamoto, Masae Yaguchi, Masahiro Toda, Ichiro Azuma, Takehisa Iwai and Yutaka Kawakami
    Clin Cancer Res December 15 2006 12 (24) 7465-7475; DOI:10.1158/1078-0432.CCR-06-1840

  • Cancer Therapy: Preclinical
    Identification of a Highly Immunogenic HLA-A*01-Binding T Cell Epitope of WT1
    Anne Marie Asemissen, Ulrich Keilholz, Stefan Tenzer, Margret Müller, Steffen Walter, Stefan Stevanovic, Hansjörg Schild, Anne Letsch, Eckhard Thiel, Hans-Georg Rammensee and Carmen Scheibenbogen
    Clin Cancer Res December 15 2006 12 (24) 7476-7482; DOI:10.1158/1078-0432.CCR-06-1337

  • Cancer Therapy: Preclinical
    Pharmacokinetics, Metabolism, and Oral Bioavailability of the DNA Methyltransferase Inhibitor 5-Fluoro-2′-Deoxycytidine in Mice
    Jan H. Beumer, Julie L. Eiseman, Robert A. Parise, Erin Joseph, Julianne L. Holleran, Joseph M. Covey and Merrill J. Egorin
    Clin Cancer Res December 15 2006 12 (24) 7483-7491; DOI:10.1158/1078-0432.CCR-06-1250

  • Cancer Therapy: Preclinical
    Transcriptional Repression of Hepatic Cytochrome P450 3A4 Gene in the Presence of Cancer
    Kellie A. Charles, Laurent P. Rivory, Sandie L. Brown, Christopher Liddle, Stephen J. Clarke and Graham R. Robertson
    Clin Cancer Res December 15 2006 12 (24) 7492-7497; DOI:10.1158/1078-0432.CCR-06-0023

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Clinical Cancer Research: 12 (24)
December 2006
Volume 12, Issue 24
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Issue Highlights

  • RNASEN Regulates Cell Proliferation and Affects Survival in Esophageal Cancer Patients
  • Aberrant Promoter Methylation Profile and Association with Survival in Patients with Non–Small Cell Lung Cancer
  • Active Antiviral T-Lymphocyte Response Can Be Redirected against Tumor Cells by Antitumor Antibody × MHC/Viral Peptide Conjugates
  • Inhibitory Effects of Castration in an Orthotopic Model of Androgen-Independent Prostate Cancer Can Be Mimicked and Enhanced by Angiogenesis Inhibition

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  • Cancer Therapy: Clinical
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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