Clinical Cancer Research: 12 (24)

Editorial

Editorial

Effective Strategies for Tumors Affecting Chemopreventive Metabolism

Jeroen T.M. Buters

Clin Cancer Res December 15 2006 12 (24) 7203-7204; DOI:10.1158/1078-0432.CCR-06-1752

The Biology Behind

The Biology Behind

Circulating Methylated DNA: A New Generation of Tumor Markers

Martin Widschwendter and Usha Menon

Clin Cancer Res December 15 2006 12 (24) 7205-7208; DOI:10.1158/1078-0432.CCR-06-2531

CCR Practice of Translational Oncology

CCR Practice of Translational Oncology

Chips to Bedside: Incorporation of Microarray Data into Clinical Practice

Lajos Pusztai

Clin Cancer Res December 15 2006 12 (24) 7209-7214; DOI:10.1158/1078-0432.CCR-06-2649

Molecular Pathways

Molecular Pathways

Targeting von Hippel-Lindau Pathway in Renal Cell Carcinoma

Premal H. Patel, Rajendrakumar S.V. Chadalavada, R.S.K. Chaganti and Robert J. Motzer

Clin Cancer Res December 15 2006 12 (24) 7215-7220; DOI:10.1158/1078-0432.CCR-06-2254

CCR Focus

CCR Focus

From the Editor

Susan E. Bates

Clin Cancer Res December 15 2006 12 (24) 7221-7221; DOI:10.1158/1078-0432.CCR-12-24-INT
CCR Focus

Epidermal Growth Factor Receptor Activation: How Exon 19 and 21 Mutations Changed Our Understanding of the Pathway

Rafael Rosell, Miquel Taron, Noemi Reguart, Dolores Isla and Teresa Moran

Clin Cancer Res December 15 2006 12 (24) 7222-7231; DOI:10.1158/1078-0432.CCR-06-0627
CCR Focus

Update on Epidermal Growth Factor Receptor Mutations in Non–Small Cell Lung Cancer

Gregory J. Riely, Katerina A. Politi, Vincent A. Miller and William Pao

Clin Cancer Res December 15 2006 12 (24) 7232-7241; DOI:10.1158/1078-0432.CCR-06-0658
CCR Focus

Molecular Mechanisms of Epidermal Growth Factor Receptor (EGFR) Activation and Response to Gefitinib and Other EGFR-Targeting Drugs

Mayumi Ono and Michihiko Kuwano

Clin Cancer Res December 15 2006 12 (24) 7242-7251; DOI:10.1158/1078-0432.CCR-06-0646
CCR Focus

Mechanisms of egfr Gene Transcription Modulation: Relationship to Cancer Risk and Therapy Response

Burkhard Brandt, Sönke Meyer-Staeckling, Hartmut Schmidt, Konstantin Agelopoulos and Horst Buerger

Clin Cancer Res December 15 2006 12 (24) 7252-7260; DOI:10.1158/1078-0432.CCR-06-0626
CCR Focus

Epidermal Growth Factor Receptor–Mediated Signal Transduction in the Development and Therapy of Gliomas

M. Kelly Nicholas, Rimas V. Lukas, Nazia F. Jafri, Leonardo Faoro and Ravi Salgia

Clin Cancer Res December 15 2006 12 (24) 7261-7270; DOI:10.1158/1078-0432.CCR-06-0874

Report from FDA

Report from FDA

Sorafenib for the Treatment of Advanced Renal Cell Carcinoma

Robert C. Kane, Ann T. Farrell, Haleh Saber, Shenghui Tang, Gene Williams, Josephine M. Jee, Chengyi Liang, Brian Booth, Nallaperumal Chidambaram, David Morse, Rajeshwari Sridhara, Patricia Garvey, Robert Justice and Richard Pazdur

Clin Cancer Res December 15 2006 12 (24) 7271-7278; DOI:10.1158/1078-0432.CCR-06-1249

Perspective

Perspective

Maspin: The New Frontier

Zhila Khalkhali-Ellis

Clin Cancer Res December 15 2006 12 (24) 7279-7283; DOI:10.1158/1078-0432.CCR-06-1589

Human Cancer Biology

Human Cancer Biology

Amplification and Overexpression of CACNA1E Correlates with Relapse in Favorable Histology Wilms' Tumors

Rachael Natrajan, Suzanne E. Little, Jorge S. Reis-Filho, Lara Hing, Boo Messahel, Paul E. Grundy, Jeffrey S. Dome, Toni Schneider, Gordan M. Vujanic, Kathy Pritchard-Jones and Chris Jones

Clin Cancer Res December 15 2006 12 (24) 7284-7293; DOI:10.1158/1078-0432.CCR-06-1567
Human Cancer Biology

β₂-Microglobulin Promotes the Growth of Human Renal Cell Carcinoma through the Activation of the Protein Kinase A, Cyclic AMP–Responsive Element-Binding Protein, and Vascular Endothelial Growth Factor Axis

Takeo Nomura, Wen-Chin Huang, Haiyen E. Zhau, Daqing Wu, Zhihui Xie, Hiromitsu Mimata, Majd Zayzafoon, Andrew N. Young, Fray F. Marshall, M. Neale Weitzmann and Leland W.K. Chung

Clin Cancer Res December 15 2006 12 (24) 7294-7305; DOI:10.1158/1078-0432.CCR-06-2060
Human Cancer Biology

Profiling of CD4⁺, CD8⁺, and CD4⁺CD25⁺CD45RO⁺FoxP3⁺ T Cells in Patients with Malignant Glioma Reveals Differential Expression of the Immunologic Transcriptome Compared with T Cells from Healthy Volunteers

Chris A. Learn, Peter E. Fecci, Robert J. Schmittling, Weihua Xie, Isaac Karikari, Duane A. Mitchell, Gary E. Archer, ZhengZheng Wei, Holly Dressman and John H. Sampson

Clin Cancer Res December 15 2006 12 (24) 7306-7315; DOI:10.1158/1078-0432.CCR-06-1727
Human Cancer Biology

The Coamplification Pattern of the MYCN Amplicon Is an Invariable Attribute of Most MYCN-Amplified Human Neuroblastomas

Axel Weber, Sven Starke, Eckhard Bergmann and Holger Christiansen

Clin Cancer Res December 15 2006 12 (24) 7316-7321; DOI:10.1158/1078-0432.CCR-06-0837

Imaging, Diagnosis, Prognosis

Imaging, Diagnosis, Prognosis

RNASEN Regulates Cell Proliferation and Affects Survival in Esophageal Cancer Patients

Nobuyoshi Sugito, Hideyuki Ishiguro, Yoshiyuki Kuwabara, Masahiro Kimura, Akira Mitsui, Hiroki Kurehara, Takuya Ando, Ryota Mori, Nobuhiro Takashima, Ryo Ogawa and Yoshitaka Fujii

Clin Cancer Res December 15 2006 12 (24) 7322-7328; DOI:10.1158/1078-0432.CCR-06-0515
Imaging, Diagnosis, Prognosis

Aberrant Promoter Methylation Profile and Association with Survival in Patients with Non–Small Cell Lung Cancer

Jian Gu, David Berman, Charles Lu, Ignacio I. Wistuba, Jack A. Roth, Marsha Frazier, Margaret R. Spitz and Xifeng Wu

Clin Cancer Res December 15 2006 12 (24) 7329-7338; DOI:10.1158/1078-0432.CCR-06-0894
Imaging, Diagnosis, Prognosis

Vascular Cell Adhesion Molecule 1 Predicts Cancer-Free Survival in Clear Cell Renal Carcinoma Patients

Ko-ichi Shioi, Atsushi Komiya, Keiko Hattori, Ying Huang, Futoshi Sano, Takayuki Murakami, Noboru Nakaigawa, Takeshi Kishida, Yoshinobu Kubota, Yoji Nagashima and Masahiro Yao

Clin Cancer Res December 15 2006 12 (24) 7339-7346; DOI:10.1158/1078-0432.CCR-06-1737
Imaging, Diagnosis, Prognosis

Methylation of Serum DNA Is an Independent Prognostic Marker in Colorectal Cancer

Maike Wallner, Andreas Herbst, Andrea Behrens, Alexander Crispin, Petra Stieber, Burkhard Göke, Rolf Lamerz and Frank T. Kolligs

Clin Cancer Res December 15 2006 12 (24) 7347-7352; DOI:10.1158/1078-0432.CCR-06-1264
Imaging, Diagnosis, Prognosis

Implications of Methylation Patterns of Cancer Genes in Salivary Gland Tumors

Michelle D. Williams, Nitin Chakravarti, Merrill S. Kies, Shin-Ichiro Maruya, Jeffrey N. Myers, Joie C. Haviland, Randal S. Weber, Reuben Lotan and Adel K. El-Naggar

Clin Cancer Res December 15 2006 12 (24) 7353-7358; DOI:10.1158/1078-0432.CCR-06-1272
Imaging, Diagnosis, Prognosis

Molecular Profiling of ADAM12 in Human Bladder Cancer

Camilla Fröhlich, Reidar Albrechtsen, Lars Dyrskjøt, Lise Rudkjær, Torben F. Ørntoft and Ulla M. Wewer

Clin Cancer Res December 15 2006 12 (24) 7359-7368; DOI:10.1158/1078-0432.CCR-06-1066
Imaging, Diagnosis, Prognosis

Ki-67 Is an Independent Predictor of Bladder Cancer Outcome in Patients Treated with Radical Cystectomy for Organ-Confined Disease

Vitaly Margulis, Shahrokh F. Shariat, Raheela Ashfaq, Arthur I. Sagalowsky and Yair Lotan

Clin Cancer Res December 15 2006 12 (24) 7369-7373; DOI:10.1158/1078-0432.CCR-06-1472

Cancer Therapy: Clinical

Cancer Therapy: Clinical

Contribution of ABL Kinase Domain Mutations to Imatinib Resistance in Different Subsets of Philadelphia-Positive Patients: By the GIMEMA Working Party on Chronic Myeloid Leukemia

Simona Soverini, Sabrina Colarossi, Alessandra Gnani, Gianantonio Rosti, Fausto Castagnetti, Angela Poerio, Ilaria Iacobucci, Marilina Amabile, Elisabetta Abruzzese, Ester Orlandi, Franca Radaelli, Fabrizio Ciccone, Mario Tiribelli, Roberto di Lorenzo, Clementina Caracciolo, Barbara Izzo, Fabrizio Pane, Giuseppe Saglio, Michele Baccarani, Giovanni Martinelli and ; on behalf of the GIMEMA Working Party on Chronic Myeloid Leukemia

Clin Cancer Res December 15 2006 12 (24) 7374-7379; DOI:10.1158/1078-0432.CCR-06-1516
Cancer Therapy: Clinical

Immunologic and Clinical Effects of Injecting Mature Peptide-Loaded Dendritic Cells by Intralymphatic and Intranodal Routes in Metastatic Melanoma Patients

Thierry Lesimple, Eve-Marie Neidhard, Virginie Vignard, Claudia Lefeuvre, Henri Adamski, Nathalie Labarrière, André Carsin, Delphine Monnier, Brigitte Collet, Gilles Clapisson, Brigitte Birebent, Irène Philip, Louis Toujas, Mohamed Chokri and Véronique Quillien

Clin Cancer Res December 15 2006 12 (24) 7380-7388; DOI:10.1158/1078-0432.CCR-06-1879
Cancer Therapy: Clinical

A Neoadjuvant/Adjuvant Randomized Trial of Colorectal Cancer Patients Vaccinated with an Anti-Idiotypic Antibody, 105AD7, Mimicking CD55

Gustav J. Ullenhag, Ian Spendlove, Nicholas F.S. Watson, Adrian A. Indar, Mukul Dube, Richard A. Robins, Charles Maxwell-Armstrong, John H. Scholefield and Lindy G. Durrant

Clin Cancer Res December 15 2006 12 (24) 7389-7396; DOI:10.1158/1078-0432.CCR-06-1003
Cancer Therapy: Clinical

HER2-Specific T-Cell Immune Responses in Patients Vaccinated with Truncated HER2 Protein Complexed with Nanogels of Cholesteryl Pullulan

Shigehisa Kitano, Shinichi Kageyama, Yasuhiro Nagata, Yoshihiro Miyahara, Atsunori Hiasa, Hiroaki Naota, Satoshi Okumura, Hiroshi Imai, Taizo Shiraishi, Masahiro Masuya, Masakatsu Nishikawa, Junzo Sunamoto, Kazunari Akiyoshi, Takashi Kanematsu, Andrew M. Scott, Roger Murphy, Eric W. Hoffman, Lloyd J. Old and Hiroshi Shiku

Clin Cancer Res December 15 2006 12 (24) 7397-7405; DOI:10.1158/1078-0432.CCR-06-1546
Cancer Therapy: Clinical

Phase I, Pharmacokinetic, and Biological Study of Erlotinib in Combination with Paclitaxel and Carboplatin in Patients with Advanced Solid Tumors

Amita Patnaik, Debra Wood, Anthony W. Tolcher, Marta Hamilton, Jeffrey I. Kreisberg, Lisa A. Hammond, Garry Schwartz, Muralidhar Beeram, Manuel Hidalgo, Monica M. Mita, Julie Wolf, Paul Nadler and Eric K. Rowinsky

Clin Cancer Res December 15 2006 12 (24) 7406-7413; DOI:10.1158/1078-0432.CCR-06-1886
Cancer Therapy: Clinical

Rapid Androgen Cycling as Treatment for Patients with Prostate Cancer

David Feltquate, Luke Nordquist, Caitlin Eicher, Michael Morris, Oren Smaletz, Susan Slovin, Tracy Curley, Andrew Wilton, Martin Fleisher, Glenn Heller and Howard I. Scher

Clin Cancer Res December 15 2006 12 (24) 7414-7421; DOI:10.1158/1078-0432.CCR-06-1496

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

Active Antiviral T-Lymphocyte Response Can Be Redirected against Tumor Cells by Antitumor Antibody × MHC/Viral Peptide Conjugates

Valérie Cesson, Kathrin Stirnemann, Bruno Robert, Immanuel Luescher, Thomas Filleron, Giampietro Corradin, Jean-Pierre Mach and Alena Donda

Clin Cancer Res December 15 2006 12 (24) 7422-7430; DOI:10.1158/1078-0432.CCR-06-1862
Cancer Therapy: Preclinical

Inhibitory Effects of Castration in an Orthotopic Model of Androgen-Independent Prostate Cancer Can Be Mimicked and Enhanced by Angiogenesis Inhibition

Peter Hammarsten, Sofia Halin, Pernilla Wikstöm, Roger Henriksson, Stina Häggström Rudolfsson and Anders Bergh

Clin Cancer Res December 15 2006 12 (24) 7431-7436; DOI:10.1158/1078-0432.CCR-06-1895
Cancer Therapy: Preclinical

Systemic Anthrax Lethal Toxin Therapy Produces Regressions of Subcutaneous Human Melanoma Tumors in Athymic Nude Mice

Ralph J. Abi-Habib, Ravibhushan Singh, Stephen H. Leppla, John J. Greene, Yan Ding, Bree Berghuis, Nicholas S. Duesbery and Arthur E. Frankel

Clin Cancer Res December 15 2006 12 (24) 7437-7443; DOI:10.1158/1078-0432.CCR-06-2019
Cancer Therapy: Preclinical

Preclinical Evaluation of Antiangiogenic Thrombospondin-1 Peptide Mimetics, ABT-526 and ABT-510, in Companion Dogs with Naturally Occurring Cancers

Anthony Rusk, Evelyn McKeegan, Fortuna Haviv, Sandra Majest, Jack Henkin and Chand Khanna

Clin Cancer Res December 15 2006 12 (24) 7444-7455; DOI:10.1158/1078-0432.CCR-06-0109
Cancer Therapy: Preclinical

Cooperative Activity of Cytotoxic Chemotherapy with Antiangiogenic Thrombospondin-I Peptides, ABT-526 in Pet Dogs with Relapsed Lymphoma

Anthony Rusk, Elizabeth Cozzi, Marty Stebbins, David Vail, Joanne Graham, Victor Valli, Jack Henkin, Rick Sharpee and Chand Khanna

Clin Cancer Res December 15 2006 12 (24) 7456-7464; DOI:10.1158/1078-0432.CCR-06-0110
Cancer Therapy: Preclinical

Enhancement of Immunologic Tumor Regression by Intratumoral Administration of Dendritic Cells in Combination with Cryoablative Tumor Pretreatment and Bacillus Calmette-Guerin Cell Wall Skeleton Stimulation

Masaru Udagawa, Chie Kudo-Saito, Go Hasegawa, Kazuhito Yano, Aiko Yamamoto, Masae Yaguchi, Masahiro Toda, Ichiro Azuma, Takehisa Iwai and Yutaka Kawakami

Clin Cancer Res December 15 2006 12 (24) 7465-7475; DOI:10.1158/1078-0432.CCR-06-1840
Cancer Therapy: Preclinical

Identification of a Highly Immunogenic HLA-A*01-Binding T Cell Epitope of WT1

Anne Marie Asemissen, Ulrich Keilholz, Stefan Tenzer, Margret Müller, Steffen Walter, Stefan Stevanovic, Hansjörg Schild, Anne Letsch, Eckhard Thiel, Hans-Georg Rammensee and Carmen Scheibenbogen

Clin Cancer Res December 15 2006 12 (24) 7476-7482; DOI:10.1158/1078-0432.CCR-06-1337
Cancer Therapy: Preclinical

Pharmacokinetics, Metabolism, and Oral Bioavailability of the DNA Methyltransferase Inhibitor 5-Fluoro-2′-Deoxycytidine in Mice

Jan H. Beumer, Julie L. Eiseman, Robert A. Parise, Erin Joseph, Julianne L. Holleran, Joseph M. Covey and Merrill J. Egorin

Clin Cancer Res December 15 2006 12 (24) 7483-7491; DOI:10.1158/1078-0432.CCR-06-1250
Cancer Therapy: Preclinical

Transcriptional Repression of Hepatic Cytochrome P450 3A4 Gene in the Presence of Cancer

Kellie A. Charles, Laurent P. Rivory, Sandie L. Brown, Christopher Liddle, Stephen J. Clarke and Graham R. Robertson

Clin Cancer Res December 15 2006 12 (24) 7492-7497; DOI:10.1158/1078-0432.CCR-06-0023

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Table of Contents

Editorial

The Biology Behind

CCR Practice of Translational Oncology

Molecular Pathways

CCR Focus

Report from FDA

Perspective

Human Cancer Biology

Imaging, Diagnosis, Prognosis

Cancer Therapy: Clinical

Cancer Therapy: Preclinical

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