Clinical Cancer Research: 12 (8)

The Biology Behind

The Biology Behind

Immunogenic Cell Death and Cross-Priming Are Reaching the Clinical Immunotherapy Arena

Ignacio Melero, Ainhoa Arina, Oihana Murillo, Juan Dubrot, Carlos Alfaro, Jose L. Pérez-Gracia, Maurizio Bendandi and Sandra Hervás-Stubbs

Clin Cancer Res April 15 2006 12 (8) 2385-2389; DOI:10.1158/1078-0432.CCR-06-0314

Molecular Pathways

Molecular Pathways

Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Pathway and Its Therapeutic Implications

Elisabeth G.E. de Vries, Jourik A. Gietema and Steven de Jong

Clin Cancer Res April 15 2006 12 (8) 2390-2393; DOI:10.1158/1078-0432.CCR-06-0352

Human Cancer Biology

Human Cancer Biology

Alterations in the T-Cell Receptor Variable β Gene–Restricted Profile of CD8⁺ T Lymphocytes in the Peripheral Circulation of Patients with Squamous Cell Carcinoma of the Head and Neck

Andreas E. Albers, Carmen Visus, Takashi Tsukishiro, Robert L. Ferris, William Gooding, Theresa L. Whiteside and Albert B. De Leo

Clin Cancer Res April 15 2006 12 (8) 2394-2403; DOI:10.1158/1078-0432.CCR-05-1818
Human Cancer Biology

Transcriptional and Posttranscriptional Down-Regulation of the Imprinted Tumor Suppressor Gene ARHI (DRAS3) in Ovarian Cancer

Zhen Lu, Robert Z. Luo, Hongqi Peng, Daniel G. Rosen, E. Neely Atkinson, Carla Warneke, Maosheng Huang, Arata Nishmoto, Jinsong Liu, Warren S-L. Liao, Yinhua Yu and Robert C. Bast Jr.

Clin Cancer Res April 15 2006 12 (8) 2404-2413; DOI:10.1158/1078-0432.CCR-05-1036
Human Cancer Biology

Molecular Evidence for the Same Clonal Origin of Multifocal Papillary Thyroid Carcinomas

Ryan P. McCarthy, Mingsheng Wang, Timothy D. Jones, Randall W. Strate and Liang Cheng

Clin Cancer Res April 15 2006 12 (8) 2414-2418; DOI:10.1158/1078-0432.CCR-05-2818
Human Cancer Biology

Establishment of Perineural Invasion Models and Analysis of Gene Expression Revealed an Invariant Chain (CD74) as a Possible Molecule Involved in Perineural Invasion in Pancreatic Cancer

Norimasa Koide, Taketo Yamada, Rie Shibata, Taisuke Mori, Mariko Fukuma, Ken Yamazaki, Koichi Aiura, Motohide Shimazu, Setsuo Hirohashi, Yuji Nimura and Michiie Sakamoto

Clin Cancer Res April 15 2006 12 (8) 2419-2426; DOI:10.1158/1078-0432.CCR-05-1852
Human Cancer Biology

Human Melanoma Metastases Express Functional CXCR4

Stefania Scala, Paola Giuliano, Paolo A. Ascierto, Caterina Ieranò, Renato Franco, Maria Napolitano, Alessandro Ottaiano, Maria L. Lombardi, Monica Luongo, Ester Simeone, Daniele Castiglia, Francesca Mauro, Ileana De Michele, Rosa Calemma, Gerardo Botti, Corrado Caracò, Gianfranco Nicoletti, Rocco A. Satriano and Giuseppe Castello

Clin Cancer Res April 15 2006 12 (8) 2427-2433; DOI:10.1158/1078-0432.CCR-05-1940

Imaging, Diagnosis, Prognosis

Imaging, Diagnosis, Prognosis

Identification of a Set of Seven Genes for the Monitoring of Minimal Residual Disease in Pediatric Acute Myeloid Leukemia

Daniel Steinbach, Alexander Schramm, Angelika Eggert, Masanori Onda, Kristin Dawczynski, Andreas Rump, Ira Pastan, Susann Wittig, Nadine Pfaffendorf, Astrid Voigt, Felix Zintl and Bernd Gruhn

Clin Cancer Res April 15 2006 12 (8) 2434-2441; DOI:10.1158/1078-0432.CCR-05-2552
Imaging, Diagnosis, Prognosis

Expression of KLF5 is a Prognostic Factor for Disease-Free Survival and Overall Survival in Patients with Breast Cancer

Dan Tong, Klaus Czerwenka, Georg Heinze, Martin Ryffel, Eva Schuster, Armin Witt, Sepp Leodolter and Robert Zeillinger

Clin Cancer Res April 15 2006 12 (8) 2442-2448; DOI:10.1158/1078-0432.CCR-05-0964
Imaging, Diagnosis, Prognosis

Coexpression of Actin-Related Protein 2 and Wiskott-Aldrich Syndrome Family Verproline-Homologous Protein 2 in Adenocarcinoma of the Lung

Seitaro Semba, Keiichi Iwaya, Jun Matsubayashi, Hiromi Serizawa, Hiroaki Kataba, Takashi Hirano, Harubumi Kato, Takeshi Matsuoka and Kiyoshi Mukai

Clin Cancer Res April 15 2006 12 (8) 2449-2454; DOI:10.1158/1078-0432.CCR-05-2566
Imaging, Diagnosis, Prognosis

High-Resolution Mapping of Tumor Redox Status by Magnetic Resonance Imaging Using Nitroxides as Redox-Sensitive Contrast Agents

Ken-ichiro Matsumoto, Fuminori Hyodo, Atsuko Matsumoto, Alan P. Koretsky, Anastasia L. Sowers, James B. Mitchell and Murali C. Krishna

Clin Cancer Res April 15 2006 12 (8) 2455-2462; DOI:10.1158/1078-0432.CCR-05-2747
Imaging, Diagnosis, Prognosis

Measuring Tissue-Based Biomarkers by Immunochromatography Coupled with Reverse-Phase Lysate Microarray

Martin J. Romeo, John Wunderlich, Lien Ngo, Steven A. Rosenberg, Seth M. Steinberg and David M. Berman

Clin Cancer Res April 15 2006 12 (8) 2463-2467; DOI:10.1158/1078-0432.CCR-05-1479
Imaging, Diagnosis, Prognosis

Bcl-2 Is a Prognostic Marker in Breast Cancer Independently of the Nottingham Prognostic Index

Grace M. Callagy, Paul D. Pharoah, Sarah E. Pinder, Forrest D. Hsu, Torsten O. Nielsen, Joseph Ragaz, Ian O. Ellis, David Huntsman and Carlos Caldas

Clin Cancer Res April 15 2006 12 (8) 2468-2475; DOI:10.1158/1078-0432.CCR-05-2719
Imaging, Diagnosis, Prognosis

Weak Expression of Focal Adhesion Kinase (pp125FAK) in Patients with Cervical Cancer Is Associated with Poor Disease Outcome

Boris Gabriel, Axel zur Hausen, Elmar Stickeler, Carola Dietz, Gerald Gitsch, Dagmar-C. Fischer, Jiri Bouda, Clemens Tempfer and Annette Hasenburg

Clin Cancer Res April 15 2006 12 (8) 2476-2483; DOI:10.1158/1078-0432.CCR-05-1867
Imaging, Diagnosis, Prognosis

A Combination of Molecular Markers Accurately Detects Lymph Node Metastasis in Non–Small Cell Lung Cancer Patients

Liqiang Xi, Michael C. Coello, Virginia R. Litle, Siva Raja, William E. Gooding, Samuel A. Yousem, Talal El-Hefnawy, Rodney J. Landreneau, James D. Luketich and Tony E. Godfrey

Clin Cancer Res April 15 2006 12 (8) 2484-2491; DOI:10.1158/1078-0432.CCR-05-2037
Imaging, Diagnosis, Prognosis

Immunohistochemical and Genetic Evaluation of Deoxycytidine Kinase in Pancreatic Cancer: Relationship to Molecular Mechanisms of Gemcitabine Resistance and Survival

Valeria Sebastiani, Francesca Ricci, Belen Rubio-Viquiera, Piotr Kulesza, Charles J. Yeo, Manuel Hidalgo, Alison Klein, Daniel Laheru and Christine A. Iacobuzio-Donahue

Clin Cancer Res April 15 2006 12 (8) 2492-2497; DOI:10.1158/1078-0432.CCR-05-2655
Imaging, Diagnosis, Prognosis

The Diagnostic Accuracy of Reverse Transcription-PCR Quantification of Cytokeratin mRNA in the Detection of Sentinel Lymph Node Invasion in Oral and Oropharyngeal Squamous Cell Carcinoma: A Comparison with Immunohistochemistry

Renaud Garrel, Mathilde Dromard, Valérie Costes, Eric Barbotte, Frédéric Comte, Quentin Gardiner, César Cartier, Marc Makeieff, Louis Crampette, Bernard Guerrier and Nathalie Boulle

Clin Cancer Res April 15 2006 12 (8) 2498-2505; DOI:10.1158/1078-0432.CCR-05-2136
Imaging, Diagnosis, Prognosis

N-Acetylglucosaminyltransferase V and β1-6 Branching N-Linked Oligosaccharides Are Associated with Good Prognosis of Patients with Bladder Cancer

Hirofumi Ishimura, Toshiko Takahashi, Hiroaki Nakagawa, Shin-Ichiro Nishimura, Yoichi Arai, Yohei Horikawa, Tomonori Habuchi, Eiji Miyoshi, Atsushi Kyan, Shigeru Hagisawa and Chikara Ohyama

Clin Cancer Res April 15 2006 12 (8) 2506-2511; DOI:10.1158/1078-0432.CCR-05-1938
Imaging, Diagnosis, Prognosis

Reduced Plasma RNA Integrity in Nasopharyngeal Carcinoma Patients

Blenda C.K. Wong, K.C. Allen Chan, Anthony T.C. Chan, Sing-Fai Leung, Lisa Y.S. Chan, Katherine C.K. Chow and Y.M. Dennis Lo

Clin Cancer Res April 15 2006 12 (8) 2512-2516; DOI:10.1158/1078-0432.CCR-05-2572

Cancer Therapy: Clinical

Cancer Therapy: Clinical

A Phase II Trial of Intraperitoneal Photodynamic Therapy for Patients with Peritoneal Carcinomatosis and Sarcomatosis

Stephen M. Hahn, Douglas L. Fraker, Rosemarie Mick, James Metz, Theresa M. Busch, Debbie Smith, Timothy Zhu, Carmen Rodriguez, Andreea Dimofte, Francis Spitz, Mary Putt, Stephen C. Rubin, Chandrakala Menon, Hsing-Wen Wang, Daniel Shin, Arjun Yodh and Eli Glatstein

Clin Cancer Res April 15 2006 12 (8) 2517-2525; DOI:10.1158/1078-0432.CCR-05-1625
Cancer Therapy: Clinical

Evaluation of Prime/Boost Regimens Using Recombinant Poxvirus/Tyrosinase Vaccines for the Treatment of Patients with Metastatic Melanoma

Kimberly R. Lindsey, Linda Gritz, Richard Sherry, Andrea Abati, Patricia A. Fetsch, Lisa C. Goldfeder, Monica I. Gonzales, Kimberly A. Zinnack, Linda Rogers-Freezer, Leah Haworth, Sharon A. Mavroukakis, Donald E. White, Seth M. Steinberg, Nicholas P. Restifo, Dennis L. Panicali, Steven A. Rosenberg and Suzanne L. Topalian

Clin Cancer Res April 15 2006 12 (8) 2526-2537; DOI:10.1158/1078-0432.CCR-05-2061
Cancer Therapy: Clinical

Optimization of Patient Selection for Gefitinib in Non–Small Cell Lung Cancer by Combined Analysis of Epidermal Growth Factor Receptor Mutation, K-ras Mutation, and Akt Phosphorylation

Sae-Won Han, Tae-You Kim, Yoon Kyung Jeon, Pil Gyu Hwang, Seock-Ah Im, Kyung-Hun Lee, Jee Hyun Kim, Dong-Wan Kim, Dae Seog Heo, Noe Kyeong Kim, Doo Hyun Chung and Yung-Jue Bang

Clin Cancer Res April 15 2006 12 (8) 2538-2544; DOI:10.1158/1078-0432.CCR-05-2845
Cancer Therapy: Clinical

Association of DNA Repair and Steroid Metabolism Gene Polymorphisms with Clinical Late Toxicity in Patients Treated with Conformal Radiotherapy for Prostate Cancer

Sambasivarao Damaraju, David Murray, Jennifer Dufour, Diana Carandang, Sten Myrehaug, Gino Fallone, Colin Field, Russell Greiner, John Hanson, Carol E. Cass and Matthew Parliament

Clin Cancer Res April 15 2006 12 (8) 2545-2554; DOI:10.1158/1078-0432.CCR-05-2703
Cancer Therapy: Clinical

A Phase 1 Clinical Study of Intravenous Administration of PV701, an Oncolytic Virus, Using Two-Step Desensitization

Scott A. Laurie, John C. Bell, Harold L. Atkins, Joanne Roach, Michael K. Bamat, James D. O'Neil, M. Scot Roberts, William S. Groene and Robert M. Lorence

Clin Cancer Res April 15 2006 12 (8) 2555-2562; DOI:10.1158/1078-0432.CCR-05-2038

Cancer Therapy: Preclinical

Cancer Therapy: Preclinical

New Intra-arterial Drug Delivery System for the Treatment of Liver Cancer: Preclinical Assessment in a Rabbit Model of Liver Cancer

Kelvin Hong, Afsheen Khwaja, Eleni Liapi, Michael S. Torbenson, Cristos S. Georgiades and Jean-Francois H. Geschwind

Clin Cancer Res April 15 2006 12 (8) 2563-2567; DOI:10.1158/1078-0432.CCR-05-2225
Cancer Therapy: Preclinical

Systemic Antitumor Effect of Intratumoral Injection of Dendritic Cells in Combination with Local Photodynamic Therapy

Hisashi Saji, Wenru Song, Katsuyoshi Furumoto, Harubumi Kato and Edgar G. Engleman

Clin Cancer Res April 15 2006 12 (8) 2568-2574; DOI:10.1158/1078-0432.CCR-05-1986
Cancer Therapy: Preclinical

Targeted Delivery of Tumor Necrosis Factor-α to Tumor Vessels Induces a Therapeutic T Cell–Mediated Immune Response that Protects the Host Against Syngeneic Tumors of Different Histologic Origin

Enrica Balza, Lorenzo Mortara, Francesca Sassi, Stefano Monteghirfo, Barbara Carnemolla, Patrizia Castellani, Dario Neri, Roberto S. Accolla, Luciano Zardi and Laura Borsi

Clin Cancer Res April 15 2006 12 (8) 2575-2582; DOI:10.1158/1078-0432.CCR-05-2448
Cancer Therapy: Preclinical

A Novel Methionine Aminopeptidase-2 Inhibitor, PPI-2458, Inhibits Non–Hodgkin's Lymphoma Cell Proliferation In vitro and In vivo

Andrew C. Cooper, Russell M. Karp, Edward J. Clark, Nazbeh R. Taghizadeh, Jennifer G. Hoyt, Matthew T. Labenski, Michael J. Murray, Gerhard Hannig, William F. Westlin and Charles D. Thompson

Clin Cancer Res April 15 2006 12 (8) 2583-2590; DOI:10.1158/1078-0432.CCR-05-0871
Cancer Therapy: Preclinical

Potent Antitumor Activity of an Auristatin-Conjugated, Fully Human Monoclonal Antibody to Prostate-Specific Membrane Antigen

Dangshe Ma, Christine E. Hopf, Andrew D. Malewicz, Gerald P. Donovan, Peter D. Senter, William F. Goeckeler, Paul J. Maddon and William C. Olson

Clin Cancer Res April 15 2006 12 (8) 2591-2596; DOI:10.1158/1078-0432.CCR-05-2107
Cancer Therapy: Preclinical

Potential and Toxicity of Intravesical Pemetrexed: a Preclinical Study in Pigs

Kees Hendricksen, Paula M.J. Moonen, Antoine G. van der Heijden, Janneke Molkenboer-Kuenen, Christina A. Hulsbergen-van de Kaa and J. Alfred Witjes

Clin Cancer Res April 15 2006 12 (8) 2597-2601; DOI:10.1158/1078-0432.CCR-05-2644
Cancer Therapy: Preclinical

The Bisphosphonate Olpadronate Inhibits Skeletal Prostate Cancer Progression in a Green Fluorescent Protein Nude Mouse Model

Meng Yang, Doug W. Burton, Jack Geller, Darren J. Hillegonds, Randolph H. Hastings, Leonard J. Deftos and Robert M. Hoffman

Clin Cancer Res April 15 2006 12 (8) 2602-2606; DOI:10.1158/1078-0432.CCR-05-2050
Cancer Therapy: Preclinical

Protective Effect of Erythropoietin and Its Carbamylated Derivative in Experimental Cisplatin Peripheral Neurotoxicity

Roberto Bianchi, Michael Brines, Giuseppe Lauria, Costanza Savino, Alessandra Gilardini, Gabriella Nicolini, Virginia Rodriguez-Menendez, Norberto Oggioni, Annalisa Canta, Paola Penza, Raffaella Lombardi, Claudio Minoia, Anna Ronchi, Anthony Cerami, Pietro Ghezzi and Guido Cavaletti

Clin Cancer Res April 15 2006 12 (8) 2607-2612; DOI:10.1158/1078-0432.CCR-05-2177
Cancer Therapy: Preclinical

Rapamycin Inhibits Growth of Premalignant and Malignant Mammary Lesions in a Mouse Model of Ductal Carcinoma In situ

Ruria Namba, Lawrence J.T. Young, Craig K. Abbey, Lisa Kim, Patrizia Damonte, Alexander D. Borowsky, Jinyi Qi, Clifford G. Tepper, Carol L. MacLeod, Robert D. Cardiff and Jeffrey P. Gregg

Clin Cancer Res April 15 2006 12 (8) 2613-2621; DOI:10.1158/1078-0432.CCR-05-2170
Cancer Therapy: Preclinical

Efficacy of the Kinase Inhibitor SU11248 against Gastrointestinal Stromal Tumor Mutants Refractory to Imatinib Mesylate

Hans Prenen, Jan Cools, Nicole Mentens, Cedric Folens, Raf Sciot, Patrick Schöffski, Allan Van Oosterom, Peter Marynen and Maria Debiec-Rychter

Clin Cancer Res April 15 2006 12 (8) 2622-2627; DOI:10.1158/1078-0432.CCR-05-2275
Cancer Therapy: Preclinical

Roles of Nitric Oxide Synthase Inhibition and Vascular Endothelial Growth Factor Receptor-2 Inhibition on Vascular Morphology and Function in an In vivo Model of Pancreatic Cancer

E. Ramsay Camp, Anthony Yang, Wenbiao Liu, Fan Fan, Ray Somcio, Daniel J. Hicklin and Lee M. Ellis

Clin Cancer Res April 15 2006 12 (8) 2628-2633; DOI:10.1158/1078-0432.CCR-05-2257
Cancer Therapy: Preclinical

Evaluation of Antitumoral Properties of the Protease Inhibitor Indinavir in a Murine Model of Hepatocarcinoma

Vincenzo Esposito, Emanuele Palescandolo, Enrico P. Spugnini, Vincenzo Montesarchio, Antonio De Luca, Irene Cardillo, Giancarlo Cortese, Alfonso Baldi and Antonio Chirianni

Clin Cancer Res April 15 2006 12 (8) 2634-2639; DOI:10.1158/1078-0432.CCR-05-2188
Cancer Therapy: Preclinical

Preclinical Differentiation between Apparently Safe and Potentially Hepatotoxic Applications of TRAIL Either Alone or in Combination with Chemotherapeutic Drugs

Tom M. Ganten, Ronald Koschny, Jaromir Sykora, Henning Schulze-Bergkamen, Peter Büchler, Tobias L. Haas, Manuela B. Schader, Andreas Untergasser, Wolfgang Stremmel and Henning Walczak

Clin Cancer Res April 15 2006 12 (8) 2640-2646; DOI:10.1158/1078-0432.CCR-05-2635

Obituary

Obituary

John Robert Murren, M.D.: In Memoriam

Clin Cancer Res April 15 2006 12 (8) 2647-2647; DOI:10.1158/1078-0432.CCR-06-0313

Letters to the Editor

Letters to the Editor

Impact of Blood Sampling on Circulating Tissue Inhibitors of Metalloproteinases

Klaus Jung

Clin Cancer Res April 15 2006 12 (8) 2648-2648; DOI:10.1158/1078-0432.CCR-05-1592
Letters to the Editor

Reply to the Letter to the Editor from Jung

Henni Ruokolainen and Taina Turpeenniemi-Hujanen

Clin Cancer Res April 15 2006 12 (8) 2648-2648; DOI:10.1158/1078-0432.CCR-05-2435
Letters to the Editor

Comments on Plasmalemmal Vesicle Associated Protein-1 as a Novel Marker Implicated in Brain Tumor Angiogenesis

Laura A. Sanders (Strickland) and Hartmut Koeppen

Clin Cancer Res April 15 2006 12 (8) 2649-2649; DOI:10.1158/1078-0432.CCR-05-2624
Letters to the Editor

Reply to the Letter to the Editor from Sanders et al

Eleanor B. Carson-Walter and Kevin A. Walter

Clin Cancer Res April 15 2006 12 (8) 2649-2649; DOI:10.1158/1078-0432.CCR-06-0287

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Table of Contents

The Biology Behind

Molecular Pathways

Human Cancer Biology

Imaging, Diagnosis, Prognosis

Cancer Therapy: Clinical

Cancer Therapy: Preclinical

Obituary

Letters to the Editor

Issue Highlights

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