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Clinical Cancer Research
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Imaging, Diagnosis, Prognosis

Immunohistochemical and Genetic Evaluation of Deoxycytidine Kinase in Pancreatic Cancer: Relationship to Molecular Mechanisms of Gemcitabine Resistance and Survival

Valeria Sebastiani, Francesca Ricci, Belen Rubio-Viquiera, Piotr Kulesza, Charles J. Yeo, Manuel Hidalgo, Alison Klein, Daniel Laheru and Christine A. Iacobuzio-Donahue
Valeria Sebastiani
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Francesca Ricci
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Belen Rubio-Viquiera
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Piotr Kulesza
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Charles J. Yeo
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Manuel Hidalgo
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Alison Klein
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Christine A. Iacobuzio-Donahue
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DOI: 10.1158/1078-0432.CCR-05-2655 Published April 2006
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Article Information

Volume 12, Issue 8, pp. 2492-2497

DOI 
https://doi.org/10.1158/1078-0432.CCR-05-2655
PubMed 
16638857

Published By 
American Association for Cancer Research
Print ISSN 
1078-0432
Online ISSN 
1557-3265
History 
  • Accepted February 8, 2006
  • Received December 5, 2005
  • Revision received January 24, 2006
  • Published first April 25, 2006.

Copyright & Usage 
American Association for Cancer Research

Author Information

  1. Valeria Sebastiani1,
  2. Francesca Ricci1,
  3. Belen Rubio-Viquiera2,
  4. Piotr Kulesza3,
  5. Charles J. Yeo4,
  6. Manuel Hidalgo2,
  7. Alison Klein2,
  8. Daniel Laheru2 and
  9. Christine A. Iacobuzio-Donahue2,3
  1. Authors' Affiliations:1Department of Pathology, University “La Sapienza,” Rome, Italy; Departments of 2Oncology and 3Pathology, Johns Hopkins Hospital, Baltimore, Maryland; and 4Department of Surgery, Jefferson Medical College, Philadelphia, Pennsylvania
  1. Requests for reprints:
    Christine A. Iacobuzio-Donahue, Department of Gastrointestinal/Liver Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Hospital, 720 Rutland Street, Ross 632, Baltimore, MD 21205. Phone: 410-955-3511; Fax: 410-614-0671; E-mail: ciacobu{at}jhmi.edu.
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Clinical Cancer Research: 12 (8)
April 2006
Volume 12, Issue 8
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Immunohistochemical and Genetic Evaluation of Deoxycytidine Kinase in Pancreatic Cancer: Relationship to Molecular Mechanisms of Gemcitabine Resistance and Survival
Valeria Sebastiani, Francesca Ricci, Belen Rubio-Viquiera, Piotr Kulesza, Charles J. Yeo, Manuel Hidalgo, Alison Klein, Daniel Laheru and Christine A. Iacobuzio-Donahue
Clin Cancer Res April 15 2006 (12) (8) 2492-2497; DOI: 10.1158/1078-0432.CCR-05-2655

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Immunohistochemical and Genetic Evaluation of Deoxycytidine Kinase in Pancreatic Cancer: Relationship to Molecular Mechanisms of Gemcitabine Resistance and Survival
Valeria Sebastiani, Francesca Ricci, Belen Rubio-Viquiera, Piotr Kulesza, Charles J. Yeo, Manuel Hidalgo, Alison Klein, Daniel Laheru and Christine A. Iacobuzio-Donahue
Clin Cancer Res April 15 2006 (12) (8) 2492-2497; DOI: 10.1158/1078-0432.CCR-05-2655
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