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Clinical Cancer Research
Clinical Cancer Research
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About the Cover

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Irradiation of endothelial cells in vitro induces the surface exposure of anionic phospholipids, principally phosphatidylserine (shown in green in the figure). Irradiation of human lung tumors in mice likewise induces exposure of phosphatidylserine on tumor vascular endothelium. Targeting the exposed phosphatidylserine with a monoclonal antibody (2aG4) leads to host-cell mediated destruction of tumor vessels and reductions in tumor growth in the mice. Bavituximab, a chimeric version of 2aG4 in clinical trials, has the potential to improve the efficacy of radiation therapy in cancer patients by amplifying damage to tumor vasculature. For details, see the article by He and associates 5211 of this issue.

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Clinical Cancer Research: 13 (17)
September 2007
Volume 13, Issue 17
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Issue Highlights

  • Epigenetic Inactivation of IκB Kinase-α in Oral Carcinomas and Tumor Progression
  • Inactivation of HOXA Genes by Hypermethylation in Myeloid and Lymphoid Malignancy is Frequent and Associated with Poor Prognosis
  • Long-term Evaluation of Three Multiple-Case Waldenström Macroglobulinemia Families
  • Radiation-Enhanced Vascular Targeting of Human Lung Cancers in Mice with a Monoclonal Antibody That Binds Anionic Phospholipids
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Clinical Cancer Research
eISSN: 1557-3265
ISSN: 1078-0432

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